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1.
Somak Roy Kajal Kiran Dhingra Parul Gupta Nita Khurana Bulbul Gupta Ravi Meher 《Head and neck pathology》2009,3(2):163-168
Primary salivary gland carcinoma with neuroendocrine differentiation is of rare occurrence, especially so in the parotid gland.
Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
A 48 year old lady presented with a gradually increasing right infra-auricular swelling for a period of 1 year which enlarged
suddenly in a short period. Contrast Enhanced Computed Tomography (CECT) suggested diagnosis of Pleomorphic Adenoma. Fine
Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin’s tumor or Oncocytic lesion.
Intraoperative findings were suggestive of a Warthin’s tumor. Initial histopathological examination of the tumor was suggestive
of neuroendocrine carcinoma. However, extensive sectioning revealed peripheral islands of ACC. Immunoexpression of S-100,
Neuron specific Enolase (NSE), Chromogranin A and Synaptophysin confirmed the diagnosis. The possibility of neuroendocrine
differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine
histology. 相似文献
2.
In this present series, we studied in detail the cytologic features of five histopathologically verified cases of central giant-cell granuloma (CGCG). All the patients in this series were female, with an age range of 11-60 years. There were three cases with involvement of the lower jaw and two cases had upper jaw involvement. Cytology smears showed dispersed single cells in the background. Nuclei of the individual cells were round to ovoid with fine chromatin and inconspicuous nucleoli. The cytoplasm of these cells was moderate in amount with indistinct cell borders. Many randomly scattered multinucleated giant cells with 10-20 nuclei were present in the background. Combination of clinical features, radiologic pictures, and cytologic features may be helpful for diagnosis of CGCG on fine-needle aspiration cytology. 相似文献
3.
We studied the effect of the nitric oxide (NO) donor, sodium nitroprusside (SNP), on the macroscopic and single-channel currents
due to the 22-pS Ca2+ channel in smooth muscle cells from guinea pig basilar artery. In nystatin-perforated whole-cell recordings, 50 nM SNP decreased
the macroscopic current to 63±12% of control values, without changing the voltage dependence of the current. In cell-attached
patches with BAY-K8644 in the pipette, SNP caused a comparable decrease in single-channel availability (n ·P
o) that was dose dependent over the range of 10 nM to 10 μM SNP. SNP had no effect on single-channel properties, including
slope conductance, voltage dependence of activation, the number of open states, the time constants of the open states, and
the proportion of time spent in each open state. The effect of SNP (50 nM) on single Ca2+ channel openings was reproduced by 8-Br-cGMP (100 μM), which also reduced channel availability without altering channel properties.
The protein kinase inhibitor H-8 (1.5 μM), which exhibits relative specificity for cGMP-dependent protein kinase, completely
inhibited the decrease in single-channel availability expected with SNP. The dose-dependent decrease in Ca2+ channel availability caused by SNP was not altered by prior application of 8-Br-cAMP or forskolin, both of which cause an
increase in Ca2+ channel availability in these cells. Our findings suggest that NO decreases openings of Ca2+ channels in basilar artery smooth muscle cells without altering channel properties, and that it does so by a mechanism likely
to involve cGMP-dependent protein kinase.
Received: 2 July 1996 / Received after revision: 30 September 1996 / Accepted: 2 October 1996 相似文献
4.
The histopathologic features of malignant peripheral nerve sheath tumors (MPNSTs) have been well described. There have been limited studies on the cytologic features of MPNST. In this present study, we have retrospectively reviewed eight histopathology confirmed cases of MPNST over a 5-year period. Detailed cytomorphological analysis of these cases was carried out individually by two observers. On cytology, these cases were diagnosed as benign spindle-cell tumor (two), spindle-cell tumor possibly benign (one), spindle-cell tumor possibly malignant (one), malignant spindle-cell tumor (two), spindle-cell tumor, and neural origin (two). The cardinal cytomorphologic features were loosely cohesive clusters and fascicular arrangement of spindle cells with rounded ends. The kinking of nuclei was not a conspicuous finding. Fibrillary background was noted in two of the cases. Nuclear pleomorphism was ranged from mild to moderate degree. One case exhibited extensive intranuclear pseudoinclusions. Mitotic figures (including atypical forms) were present in almost all the cases. Possibly a constellation of cytologic features such as clusters of short and long fascicles of cells admixed with dissociated spindle cells of round-ended nuclei and prominent nucleoli on myxoid or fibrillary background and frequent mitosis may be helpful in diagnosis of MPNSTs. The cytomorphologic features along with clinical correlation are necessary to increase the diagnostic accuracy of MPNST on aspiration cytology. 相似文献
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6.
Manish Kuchakulla Manish Narasimman Kajal Khodamoradi Zahra Khosravizadeh Ranjith Ramasamy 《Andrologia》2021,53(1):e13615
Spermatogenesis is the essential process to maintain and promote male fertility. It is extraordinarily complex with many regulatory elements and numerous steps. The process involves several cell types, regulatory molecules, repair mechanisms and epigenetic regulators. Evidence has shown that fertility can be negatively impacted by reduced sperm DNA integrity. Sources of sperm DNA damage include replication errors and causes of DNA fragmentation which include abortive apoptosis, defective maturation and oxidative stress. This review outlines the process of spermatogenesis, spermatogonial regulation and sperm differentiation; additionally, DNA damage and currently studied DNA repair mechanisms in spermatozoon are also covered. 相似文献
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9.
Mehtani Rohit Garg Shankey Kajal Kamal Soni Shiv Lal Premkumar Madhumita 《Metabolic brain disease》2022,37(5):1291-1307
Metabolic Brain Disease - Patients with liver disease often have alteration of neurological status which requires admission to an intensive care unit. Patients with acute liver failure (ALF),... 相似文献
10.
AbstractEssential oil (EO) of ginger and oleoresins isolated from extraction solvents by GC–MS. Zingiberene was the major constituent in all the samples, and ethanol could extract the maximum quantity (21.2%) from the dried de-oiled cake (EDD) followed by EO (20.3%) as compared to oleoresins. Hydro-distilled EO contains higher oxygenated monoterpenes (22.4%) than oleoresins. EDD showed more toxicity to larvae of Plutella xylostella (LC50?=?4957.9?mg L?1) after 96?h and was followed by EDW (LC50?=?5067.6?mg L?1) and EF (LC50?=?6631.2?mg L?1). EO also showed promising efficacy (LC50?=?5875.9?mg L?1) and repellency (97.1%) against P. xylostella. 相似文献