全文获取类型
收费全文 | 391篇 |
免费 | 15篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 65篇 |
口腔科学 | 19篇 |
临床医学 | 15篇 |
内科学 | 97篇 |
皮肤病学 | 2篇 |
神经病学 | 29篇 |
特种医学 | 4篇 |
外科学 | 96篇 |
综合类 | 1篇 |
一般理论 | 1篇 |
预防医学 | 9篇 |
眼科学 | 9篇 |
药学 | 22篇 |
肿瘤学 | 34篇 |
出版年
2022年 | 7篇 |
2021年 | 6篇 |
2019年 | 6篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 3篇 |
2014年 | 8篇 |
2013年 | 11篇 |
2012年 | 16篇 |
2011年 | 14篇 |
2010年 | 11篇 |
2009年 | 8篇 |
2008年 | 16篇 |
2007年 | 14篇 |
2006年 | 12篇 |
2005年 | 19篇 |
2004年 | 13篇 |
2003年 | 12篇 |
2002年 | 18篇 |
2001年 | 16篇 |
2000年 | 15篇 |
1999年 | 23篇 |
1998年 | 4篇 |
1996年 | 5篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 11篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 4篇 |
1970年 | 2篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1965年 | 3篇 |
排序方式: 共有408条查询结果,搜索用时 15 毫秒
1.
Kajikawa K 《The Hastings Center report》1989,19(4):S29-S30
In Japan, bioethics is emerging as a discipline in which traditional Japanese values are being compared with ethical insights from scholars around the world. Kajikawa's bibliographic essay discusses recent publications on biomedical ethics by Japanese scholars that reflect topics of current interest and the public context in which they are debated. Works cited include books, conference proceedings, collaborative, multidisciplinary titles, seminar papers, an overview for the general public, and an annual bibliography of medical ethics references prepared by Tokai University. Topics include brain death and organ transplantation, nursing ethics, medical research, and bioethics and medical ethics in general. All titles are cited in English, with their Japanese publishers and dates of publication. 相似文献
2.
Harderian gland dependency of immunoglobulin A production in the lacrimal fluid of chicken 总被引:2,自引:0,他引:2 下载免费PDF全文
Involvement of the Harderian gland (HG) in the production of lacrimal immunoglobulin (especially IgA) was investigated. The lacrimal concentration of each immunoglobulin class was not affected by surgical bursectomy but was reduced by cyclophosphamide (CY) and testosterone (TP) treatments. Surgical removal of the Harderian gland caused a remarkable reduction of both the lacrimal concentration of each immunoglobulin class and the specific antibody titre, and and IgA was almost undetectable. The lacrimal concentration of each immunoglobulin class, as well as the specific antibody titre, was not affected by surgical removal of the Lacrimal gland (LG). The route of antigen administration produced no difference in the class of lacrimal immunoglobulin produced. The results indicate that the production of immunoglobulin in chicken tears may be dependent on the HG and that lacrimal immunoglobulin may be synthesized and secreted locally in the HG. Lymphocytes of the HG are of bursa of Fabricius origin and are seeded into the HG prior to hatching and its lymphocytes do not appear to be involved in systemic immunity. 相似文献
3.
4.
5.
To define the immune responses against phenotypically and pathogenically distinct lentiviruses, we used an immunoblotting assay to study antibodies to viral proteins of ovine lentivirus (OvLV) in 16 experimentally and 12 naturally infected sheep. Two distinct phenotypes of OvLV were used to experimentally infect lambs: strain 85/34, a "rapid/high" isolate which rapidly induced lysis in infected primary macrophage cultures and replicated to relatively high titers, and strains 84/28 and 85/14, "slow/low" isolates which induced slowly progressive syncytia with minimal lysis in vitro and replicated only to low titers in the same cell type. Serum antibodies against four major viral structural proteins, gp105, p25, p16, and p14, were detected. In a longitudinal study of experimentally infected lambs, the antibody to p25 (major gag protein) usually appeared first (average, about 3 weeks postinoculation [p.i.]) and was followed in about 2 weeks by p16, p14, and gp105 almost simultaneously. Six of 16 animals did not develop anti-p14 antibody by the time of necropsy at 9 to 29 weeks p.i. Two of 10 lambs which developed antibody to p14 had the antibody only transiently from 3 to 8 or 13 weeks p.i. and lost it by the time of necropsy at 21 or 22 weeks p.i. In contrast, antibodies to the other three structural proteins remained fairly constant until the time of necropsy. There were differences in the antibody responses of the experimentally infected lambs to the two phenotypes of OvLV. Seven of 10 (70%) lambs which were inoculated with the rapid/high strain developed antibody to p14, whereas only 17% of the lambs inoculated with the slow/low strains had antibody to this protein. In the longitudinal study, no decline was observed in the activity of any specific antibody such as that which occurs with anti-p24 antibody in human immunodeficiency virus infection, except in the case of anti-p14 antibody in two lambs. There were no significant differences in antibody titers against p25, p16, and p14 in final blood samples between rapid/high virus- and slow/low virus-infected groups. However, the rapid/high virus-infected group developed a fivefold-higher geometric mean titer of anti-env product (gp 105) antibody than did the slow/low virus-infected group (P = 0.1). Antibody titers to all major structural proteins, except p14, in the naturally infected sheep were markedly lower than those in experimentally induced OvLV infections (P = 0.01). The failure of the slow/low virus-infected group to develop anti-p14 antibody may suggest diminished viral replication in vivo or a failure of the host to recognize p14 in the slow/low virus-infected group. Since the geometric mean antibody titer to gp105 was threefold higher in lambs with lymphoid interstitial pneumonia than in those without lesions and since no differences were observed in the titers of other antiviral antibodies between these groups, we found no evidence to suggest that levels of such antibodies correlated with protection from OvLV-induced disease. 相似文献
6.
T Shintani N Hayakawa M Hoshi M Sumida K Kurisu S Oki Y Kodama H Kajikawa K Inai N Kamada 《Journal of radiation research》1999,40(1):49-57
Since the atomic bomb explosions in Hiroshima and Nagasaki, high incidences of leukemia, thyroid cancer and other tumors have been reported as atomic bomb-induced tumors. We investigated the incidence of meningioma among Hiroshima atomic bomb survivors. Sixty-eight patients surgically treated for meningioma who had been within 2.0 km of the hypocenter of the explosion were identified. Six hundred and seven non-exposed patients with meningioma were also studied. Treatment dates were from 1975 to 1992. The incidences of meningioma among 68 subjects within 2.0 km and 607 non-exposed patients were 8.7 and 3.0 cases per 10(5) persons per year, respectively. The incidences of meningioma among the survivors of Hiroshima in 5-year intervals since 1975 were 5.3, 7.4, 10.1, and 14.9, respectively. The incidences of meningioma classified by distances from the hypocenter of 1.5-2.0 km, 1.0-1.5 km and less than 1.0 km were 6.3, 7.6 and 20.0, respectively. The incidences of meningioma classified by doses to the brain of 0-0.099 Sv, 0.1-0.99 Sv and more than 1.0 Sv were 7.7, 9.2 and 18.2, respectively. The incidence of meningioma among Hiroshima atomic bomb survivors has increased since 1975. There was a significant correlation between the incidence and the dose of radiation to the brain. The present findings strongly suggest that meningioma is one of the tumors induced by atomic bombing in Hiroshima. 相似文献
7.
Yoshiyuki Nakatsuji Kendo Kiyosawa Eiji Tanaka Takeshi Sodeyama Naoto Horigome Shoji Kajikawa Shigeko Naito Yoshihiro Akahane 《Liver international》1991,11(3):176-184
ABSTRACT— To clarify the discrepancy in hepatitis B surface antigen (HBsAg) subtypes present in the serum and liver, as well as among hepatocytes, liver specimens which were resected from 37 HBsAg-positive patients with hepatocellular carcinoma (HCC) were examined. We evaluated HBsAg and the subtypic determinants of HBsAg and hepatitis B core antigen (HBcAg) using the peroxidase-antiperoxidase (PAP) staining method. Hepatitis B antigens were more frequently detected in small tumors (HBsAg in 67%, HBcAg in 40%) than in large ones (HBsAg in 36%, HBcAg in 14%). The prevalence of each subtypic determinant in the HBsAg positive non-tumorous vs. tumorous areas was 100% vs. 67% in a, 100% vs. 57% in d, 100% vs. not tested in y, 100% vs. 53% in r and 25% vs. 0% in w (a, d, y, r and w represent subtypic determinants). There was virtually no difference in a set of subtypic determinants between the serum and liver. However, there were some variations in a set of subtypic determinants among the hepatocytes. On the other hand, liver tissue of compound subtype adyr in serum contained both cells with a,d,r and with a,y,r as well as a few cells with a,d,y,r. These findings suggest that HBV genomes in hepatocytes of type B chronic liver disease may differ genetically among cells even in the same liver tissue. 相似文献
8.
Kuriyama M Kato J Kuwaki K Morimoto N Nawa T Fujimoto T Kono H Okano N Miyaike J Morita T Okada H Suzuki S Yoshioka T Shiode J Suwaki K Sakaguchi K Shiratori Y;Japan West Ulcerative Colitis Study Group 《European journal of gastroenterology & hepatology》2008,20(7):634-641
BACKGROUND AND AIM: The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. METHODS: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. RESULTS: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. CONCLUSION: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients. 相似文献
9.
Yamaura T Matsumoto A Rokuhara A Ichijo T Tanaka E Hanazaki K Kajikawa S Kiyosawa K 《Journal of gastroenterology and hepatology》2002,17(11):1229-1235
We report a case of hepatocellular carcinoma (HCC) that developed 77 months following sustained and complete response to interferon (IFN) therapy for chronic hepatitis C. A 67-year-old Japanese woman presented with a small mass in the liver that was diagnosed as HCC, 77 months after having completed IFN therapy and having shown a complete response to the therapy with sustained normalization of serum aminotransferases and eradication of serum hepatitis C virus (HCV). Hepatitis C virus RNA was also not detected in the resected tumorous and non-tumorous liver tissues by polymerase chain reaction. This suggests that all patients with chronic HCV infection should be followed closely for as long as possible for the potential development of HCC, even after a complete and sustained response to IFN treatment. 相似文献
10.
S Hirose K Kobayashi K Kajikawa N Sawabu 《The American journal of gastroenterology》1975,64(5):382-391
A case of watery diarrhea, hypokalemia and hypercalcemia associated with an islet cell tumor was described. A 62-year old man exhibited frequent watery diarrhea and hypokalemia for two years. He had no peptic ulcer and serum gastrin level was normal. His serum calcium was abnormally high and serum phosphate was lowered. He had secretin-like activity in his plasma. Autopsy revealed a small islet cell tumor in the pancreas and several metastatic masses in the liver. Microscopic examination revealed the tumor cell was not beta, alpha nor D cells. By electron microscopy the secretion granules of the tumor cell resembled those of S, M and T cells. It was not possible to decide which of the tree cell types was responsible for the pancreatic cholera. 相似文献