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Nidom CA Yamada S Nidom RV Rahmawati K Alamudi MY Kholik Indrasari S Hayati RS Iwatsuki Horimoto K Kawaoka Y 《Virus genes》2012,44(3):459-465
Since 2003, highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry in Indonesia every year, producing
the highest number of human victims worldwide. However, little is known about the H5N1 influenza viruses that have been circulating
there in recent years. We therefore conducted surveillance studies and isolated eight H5N1 viruses from chickens. Phylogenic
analysis of their hemagglutinin and neuraminidase genes revealed that all eight viruses belonged to clade 2.1.3. However,
on the basis of nucleotide differences, these viruses could be divided into two groups. Other viruses genetically closely
related to these two groups of viruses were all Indonesian isolates, suggesting that these new isolates have been evolving
within Indonesia. Among these viruses, two distinct viruses circulated in the Kalimantan islands during the same season in
2010. Our data reveal the continued evolution of H5N1 viruses in Indonesia. 相似文献
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