葛根素的心血管系统药理作用及机理研究

纵观近年来对葛根素在心血管系统药理作用及机理研究方面的进展发现，葛根素对心血管系统具有抗心律失常、降血压、扩张冠状动脉、抗心肌缺血、抗过氧化、抗缺血-再灌注损伤、影响血液动力学和血小板聚集、保护血管等作用。其临床应用前景良好，其药效机制研究及临床应用有待更深一步的探究。     

Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes

Splenic lymphoma with villous lymphocytes (SLVL) is a recently defined subgroup of chronic B-cell lymphoproliferative diseases. The characteristic morphology of the tumor cells, together with phenotypic and cytogenetic findings, indicate that it is a distinct entity, but the nature of the cell or origin and its relationship to other low- grade lymphomas is unclear. For B-cell tumors, analysis of the variable region heavy chain (VH) genes used to encode the clonal Ig has shown marked differences between histologic categories, both in gene usage and extent of somatic mutation. An investigation of VH genes used in five typical cases of SLVL has shown somatic hypermutation from germline sequences in all cases, indicating that the cell of origin has been exposed to the hypermutation mechanism. However, no clonal heterogeneity was detectable, demonstrating that the tumor cell does not accumulate further mutations. These characteristics are similar to those found in mature postfollicular B cells, such as plasma cells. The distribution of mutations leading to replacement amino acids differed among the cases, with three of five cases showing clear evidence for antigen selection.     

Stereotaxic biopsy of non-palpable breast neoplasms with the ABBI system (USSC)

The study was concerned with application of the stereotactic automated surgical biopsy breast with the ABBI (USSC) device for verification of non-palpable breast lumps. It included 13 females, aged 34-72 (mean age--54) and lasted 6 months (1999). Microcalcinates were detected in 3 (22.8%), local cordlike tissue structures--3 (22.8%), focal shadows--7 (53.2%). Lesion size: (5 mm (16%), 5.1-10 mm (25%) and 10.1-20 mm (59%). Malignancy was diagnosed in 3 cases (22.8%), dia. 7-10 mm; atypical ductal hyperplasia--2 (8.3%), and miscellaneous benign pathology--53.2%. Adequate removal of lesions was histologically confirmed in all cases. The procedure was carried out with ambulatory monitoring, under local anesthesia, and lasted 1.5 hrs. No complications were reported. The cosmetic results were good; no analgetics were dispensed. The ABBI system proved an effective means of stereotactic surgical biopsy of the breast because it removed the entire radiologically-suspicious site as a complete tissue preparation. It provided all histological data without crushing or segmenting the preparation. Since tissue texture and, particularly, the preparation edges remained intact, the latter could be examined too, if needed. All this ruled out inaccurate interpretation, repeat biopsy and unjustified lumpectomies.     

Experience with glyciphonic ointment therapy for primary multiple basal cell carcinoma of the skin

The effectiveness of glycifone ointment treatment for primary multiple basal cell carcinoma of the skin was evaluated in 28 patients. 27 cases were cured following one or two courses the duration of which was determined by the number of foci, pattern of tumor and its total surface area.