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Neulen J; Raczek S; Pogorzelski M; Grunwald K; Yeo TK; Dvorak HF; Weich HA; Breckwoldt M 《Molecular human reproduction》1998,4(3):203-206
Vascularization is a prominent event during corpus luteum formation,
providing low density lipoproteins for steroid biosynthesis and enabling
transport of secreted steroids. The process of vascularization is
controlled by specific regulators. Vascular endothelial growth factor
(VEGF), otherwise named vascular permeability factor (VPF), induces
endothelial cell proliferation as well as angiogenesis in vivo and
increases capillary permeability. Here we report the expression of VEGF/VPF
mRNA by cultured human luteinized granulosa cells (GC) for at least 10
days. Without HCG VEGF/VPF expression declined after day 4 and by day 10
was reduced to approximately 30% of the value at day 4. However, after
culture in the presence of 1 U/ml human chorionic gonadotrophin (HCG),
expression of VEGF/VPF mRNA by GC was four times greater than control
experiments by day 10, and increased 100% from day 4 to day 10.
Simultaneously, HCG supplementation increased VEGF/VPF secretion by GC.
Medium VEGF/VPF on day 3 was 13 pM without and 11 pM with HCG. Medium
VEGF/VPF on day 10 was 6 pM without HCG and 29 pM with HCG. These results
suggest that vascularization of the corpus luteum is induced by
HCG-mediated effects of VEGF/VPF.
相似文献
7.
Lesions of the articular surfaces of the knee have been managed by various techniques over the last 50 years. Surgical management has involved: excising the damaged area, refashioning the underlying bone to produce a fibrous response, and introducing allograft, autograft and synthetic materials to encourage a repair matrix. The techniques and their pitfalls are reviewed and discussed, and suggestions made as to the direction of future studies for the repair of osteochondral lesions in the painful knee. 相似文献
8.
The effectiveness of an antiarrhythmic drug is judged by the degree of ventricular arrhythmia suppressed by the drug. It has been suggested that a certain degree of ventricular arrhythmia suppression should be targeted to prove efficacy. Targets used to define the effectiveness of an antiarrhythmic agent included an 80% reduction in the ventricular premature complexes (VPCs) and 90% suppression of nonsustained ventricular tachycardia (NVT) episodes or complete abolition of runs of sustained VT (SVT) [1]. Other dose-adjusted antiarrhythmic trials have attempted to achieve either isolated control of the PVCs of greater-than-or-equal70% [2--5] with the suppression of the high grades of arrhythmia such as couplets and NVT of >90% and 100%, respectively [2, 3]. Such targets of arrhythmia suppression were recommended to avoid errors encountered with the occurrence of the spontaneous variability of ventricular arrhythmia and to be confident that antiarrhythmic therapy has produced a true drug effect [6]. Presently, there is no evidence that suppression of these arrhythmias with type I antiarrhythmic drugs is likely to reduce sudden death [4, 6]. The survival of patients with frequent VPCs and high-grade forms (couplets [C], NVT) and organic heart disease is not dependent on the degree of arrhythmia suppression. The survival of patients with low LVEF of <40% and runs of NVT is improved and is similar to that of patients with good LVEF of greater-than-or-equal40%. Such a lack of correlation between arrhythmia suppression and survival might be a unique feature of the antifibrillatory drugs and might not be applied to the antiectopic drugs. If a high degree of arrhythmia suppression is not needed, lower targets of suppression may be necessary. Lower drug dosages may improve the risk--benefit ratio of antiarrhythmic treatment. 相似文献
9.
Renal transplant (RT) is now a therapy of choice for end stage renal disease (ESRD). The Nephrology Unit, Asvini started functioning in Dec 90 and to date 1298 sittings of hemodialysis have been given to 45 patients. Of these, 35 were in ESRD and 11 patients underwent renal transplantation at this hospital during the period Jan 91 – Dec 93. One patient expired after 18 months of transplantation due to infection. Early experience in screening patients for RT, use of immunosuppression, management of rejection episodes and protocol are presented with special emphasis on its relevance to the Armed Forces.KEY WORDS: Transplantation, Renal Failure, Immunosuppression, Rejection 相似文献
10.
Drew PJ Cule N Gough M Heer K Monson JR Lee PW Kerin MJ Duthie GS 《Journal of the Royal College of Surgeons of Edinburgh》1999,44(1):55-56
"Calmanisation" of surgical training and the introduction of the "New Deal" on doctor's hours has led to a reduction in "in service" training and a proliferation of training courses. Little research has been done into the optimum design of these courses. Education theory has shown that individuals have optimal learning styles and that these styles tend to be generalised across professional groups. It was decided, therefore, to investigate the optimal learning styles of basic surgical trainees. A learning style inventory was used to assess the preferred learning style of 52 basic surgical trainees. The predominant learning styles (86.5%) were convergent (n = 31) or accommodative (n = 14) whilst only 5 (9.6%) assimilative and 2 (3.9%) divergent styles were detected. Convergent and accommodative learners rely principally on hands on experience and problem solving as their optimal learning technique. Given the shorter hours and duration of Basic Surgical Training, in service practical training and surgical courses should be structured accordingly. 相似文献