全文获取类型
收费全文 | 740篇 |
免费 | 64篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 35篇 |
妇产科学 | 8篇 |
基础医学 | 102篇 |
口腔科学 | 45篇 |
临床医学 | 54篇 |
内科学 | 126篇 |
皮肤病学 | 21篇 |
神经病学 | 26篇 |
特种医学 | 101篇 |
外科学 | 86篇 |
综合类 | 33篇 |
预防医学 | 37篇 |
眼科学 | 33篇 |
药学 | 63篇 |
中国医学 | 2篇 |
肿瘤学 | 41篇 |
出版年
2023年 | 5篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 5篇 |
2018年 | 19篇 |
2017年 | 11篇 |
2016年 | 14篇 |
2015年 | 13篇 |
2014年 | 10篇 |
2013年 | 15篇 |
2012年 | 24篇 |
2011年 | 27篇 |
2010年 | 21篇 |
2009年 | 33篇 |
2008年 | 17篇 |
2007年 | 39篇 |
2006年 | 7篇 |
2005年 | 20篇 |
2004年 | 30篇 |
2003年 | 22篇 |
2002年 | 21篇 |
2001年 | 15篇 |
2000年 | 18篇 |
1999年 | 8篇 |
1998年 | 24篇 |
1997年 | 39篇 |
1996年 | 35篇 |
1995年 | 22篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 20篇 |
1988年 | 22篇 |
1987年 | 15篇 |
1986年 | 17篇 |
1985年 | 16篇 |
1984年 | 12篇 |
1983年 | 16篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1976年 | 5篇 |
1974年 | 8篇 |
1973年 | 6篇 |
1969年 | 6篇 |
1968年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有821条查询结果,搜索用时 15 毫秒
1.
Aditya Kelkar Caroll Webers Rohit Shetty Jai Kelkar Nikhil Labhsetwar Abhishek Pandit Madhulika Malode Sayali Tidke 《Indian journal of ophthalmology》2020,68(10):2143
Purpose:To evaluate the rate of compliance and the reasons for loss to follow-up in Indian patients with diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) being treated with anti-vascular endothelial growth factor (VEGF) therapy.Methods:This was a retrospective single-center study. Patients with DME, AMD, or RVO were eligible if they initiated anti-VEGF therapy between January 2013 and December 2017. Patients'' data were obtained from hospital electronic records, including the number of injections received, visits, details of follow-up, missed appointments, and reasons for loss to follow-up (>365 days).Results:A total of 648 patients were eligible for the study, of which 334 (51.54%) patients were lost to follow-up. Overall, 343 (64.96%) were males and the overall mean (SD) age was 66.40 (7.44) years. A total of 376 (58.0%) patients had a history of diabetes and 364 (56.2%) patients had a history of hypertension. Further, 127 (38.0), 112 (33.5), and 95 (28.4) had DME, AMD, and RVO, respectively and were lost to follow-up. The most commonly reported reason for loss to follow-up was “non-affordability” (n = 120; 41.1%) followed by “no improvement in vision” (n = 83; 28.4%). “No improvement in vision” (42.2%) and “non-affordability” (37.5%) were higher among patients with DME. No association was found in gender- and treatment-wise distribution of reasons for loss to follow-up.Conclusion:The results showed that around half of the patients with DME, AMD, and RVO were lost to follow-up to intravitreal anti-VEGF therapy, and the most common factors were “non-affordability” and “no improvement in vision.” 相似文献
2.
3.
Jaw tremor can be seen as a component of various neurological disorders such as essential tremor, Parkinson's disease, dystonia, branchial myoclonus, hereditary geniospasm, task-specific tremor, and Whipple's disease, as well as in normal situations such as shivering, and subclinical physiological jaw tremor. In most of these conditions, the jaw tremor is usually associated with tremor or other abnormal involuntary movements affecting additional body parts, and its frequency is lower than 12 Hz. Schrag and colleagues reported a patient with a high-frequency idiopathic jaw tremor, and they speculated it could be related to orthostatic tremor affecting the masseter muscles. We encountered a similar patient with intermittent rapid focal jaw tremor that was successfully treated with botulinum toxin injections to the masseters. 相似文献
4.
The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in keratinocytes at the edges of ulcers compared to normal skin, or skin adjacent to the ulcers. Staining at the ulcer edge was more intense in nonhealing ulcers for only vascular endothelial growth factor and platelet-derived growth factor, whereas staining in the adjacent skin was more intense for all factors in the nonhealing phase. For all factors staining was cytoplasmic, suggesting production in these areas. This study shows up-regulation of the production of cytokines and growth factors in keratinocytes of chronic leg ulcers that is greater when the ulcers are nonhealing. 相似文献
5.
6.
7.
Dr. Smita K. Nagle Rajendra S. Kelkar 《Indian journal of otolaryngology and head and neck surgery》2007,59(1):41-42
Spirometry can be used as an objective tool for measuring nasal patency. it is sensitive, easy to perform, comfortable to patient The only limitation being that it only can be done in institution. 相似文献
8.
9.
10.
Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. 总被引:1,自引:0,他引:1
Collins CE Benson MJ Burnham WR Rampton DS 《Alimentary pharmacology & therapeutics》1996,10(3):315-320
BACKGROUND: Inflammatory bowel disease is associated with increased mucosal release of eicosanoids. Among these, thromboxane A2 has been proposed as a possible inflammatory mediator; its suppression may be a useful therapeutic option. METHODS: Using a tissue incubation technique, we compared release of immunoreactive thromboxane B2 by colonic biopsies from patients with ulcerative colitis, Crohn's disease and controls, and assessed the inhibitory effect of picotamide, a thromboxane synthesis inhibitor-receptor antagonist, which has been widely used in Italy for management of ischaemic heart and cerebrovascular disease. RESULTS: Increased amounts of thromboxane B2 were released from biopsies from patients with active ulcerative colitis (median 238 pg/20 min/mg wet weight (interquartile range 147- 325), n = 12) and active Crohn's disease (252 (174-450), 6) compared with those from patients with quiescent ulcerative colitis (95 (61- 140), 12) or Crohn's disease (105 (57-201), 13), or controls (136 (64- 206), 8). Incubation with picotamide at concentrations between 100 microM and 1 mM reduced thromboxane B2 release (IC50 890 microM). CONCLUSION: Since increased thromboxane A2 production may have pathogenetic importance, thromboxane synthesis inhibitor-receptor antagonists such as picotamide merit therapeutic trial in the management of inflammatory bowel disease. 相似文献