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排序方式: 共有470条查询结果,搜索用时 15 毫秒
1.
Drishty Satpati Ketaki Bapat Archana Mukherjee Sharmila Banerjee Kanchan Kothari Meera Venkatesh 《Applied radiation and isotopes》2006,64(8):888-892
Studies on the development of imaging agents for targeting neuroreceptors is an area of considerable interest owing to the limited availability of specific as well as selective radiolabeled agents. Therefore, with an aim of developing a receptor-specific agent, iminodiacetic acid (IDA) derivative of 5-hydroxy tryptamine viz., HTIDA has been synthesized. HTIDA could be radiolabeled with the synthon [(99m)Tc(CO)(3)(H(2)O)(3)](+) in >98% yield. The biodistribution studies in normal Swiss mice showed that the (99m)Tc(CO)(3)-HTIDA crosses the blood-brain barrier successfully with a brain uptake of 0.5%ID/g at 5min post injection. The other relevant observations from biodistribution studies included no significant uptake in any other organ and fast clearance from blood, lungs and liver. 相似文献
2.
Manali Das Kanchan Mukhopadhyay 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2007,(6):826-829
Genetic alterations in the dopaminergic system are frequently observed in association with attention deficit hyperactivity disorder (ADHD) and a 40 bp variable number of tandem repeats (VNTR) in the 3'-untranslated region (3'-UTR) of the dopamine transporter gene (DAT1) has been investigated in different populations. Both significant association and lack of association with the10 repeat allele (10R) of DAT1 VNTR have been reported. Objective of the present investigation was to examine association of this polymorphism with ADHD in Indian children. Genotypic data obtained from ADHD probands (n = 79), their parents (n = 148) and control individuals (n = 153) were analyzed for haplotype-based haplotype relative risk analysis (HHRR), transmission disequilibrium test (TDT), and family-based association test (FBAT). HHRR analysis revealed significant (P = 0.009) transmission of shorter alleles (< or =9R). TDT analysis of informative ADHD families (n = 32) also exhibited highly significant transmission of the shorter alleles (P = 0.002). Further analysis by FBAT showed preferential transmission (P = 0.019) of the 9R allele from parents to ADHD probands. It can be inferred from the data obtained that the DAT1 3'-UTR 9R allele may confer risk of ADHD in the Indian population. 相似文献
3.
Vaidehi Garg Jayabalan Nirmal Yassine Riadi Prashant Kesharwani Kanchan Kohli Gaurav Kumar Jain 《Journal of pharmaceutical sciences》2021,110(2):871-875
This work was aimed to improve the efficacy of tacrolimus in the treatment of endotoxin-induced uveitis (EIU) using propylene glycol modified lipid vesicles termed as proglycosome nano-vesicles (PNVs). PNVs were prepared by modified film hydration method. Experimental uveitis in rabbit eye was induced by an intravitreal injection of 20 μL of the endotoxin solution containing 100 ng of lipopolysaccharide endotoxin. In vivo efficacy of PNVs was determined by studying clinical symptoms of uveitis using slit lamp examination and by quantitatively measuring levels of tumor necrosis factor-alpha, interleukin-6, leukocytes and total proteins in aqueous humor, 24 h after intravitreal injection of endotoxin. Comparison was made with healthy, untreated and tacrolimus solution treated eyes. PNVs developed were nano-sized, deformable and showed sustained release of tacrolimus over period of 12 h. In vivo results indicated statistically significant difference between the effects of PNVs in the treatment of EIU compared to tacrolimus. PNV treatment not only subsides clinical symptoms of uveitis but also prevented breakdown of blood aqueous barrier. Tacrolimus loaded PNVs are potential new topical treatment for uveitis. 相似文献
4.
Kreins Alexandra Y. Velasco Helena F. Cheong Kai-Ning Rao Kanchan Veys Paul Worth Austen Gaspar H. Bobby Booth Claire 《Journal of clinical immunology》2022,42(1):94-107
Journal of Clinical Immunology - Unconditioned hematopoietic stem cell transplantation (HSCT) is the recommended treatment for patients with adenosine deaminase (ADA)-deficient severe combined... 相似文献
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Avani Shah Keyuri Jariwala Snehalata Gupte Preeti Sharma Kanchan Mishra Kanjaksha Ghosh 《Transfusion and apheresis science》2018,57(5):672-675
Background
Extended phenotyping is one of the important method of reducing red cell alloimmunisation. Extended phenotyping of red cells from voluntary donors have many uses in addition to its application in population genetics. As there was very little data extended phenotyping on a cohort of Indian Voluntary blood donors this project was undertaken.Study design & methodology
200 regular voluntary blood donors having ‘O’ blood group were included for red cell antigen typing of Rh (D,C,E,c,e), Kell (K, k, Kpa, Kpb), Duffy (Fya, Fyb), Kidd (Jka, Jkb), Lewis(Lea, Leb), P(P1), MNS (M, N,S,s), and Lutheran (Lua, Lub), Colton (Coa, Cob), Diago (Diaa, Wra), Vw and Xga antigens using conventional antisera provided by DIAGAST. Calculations of antigen and phenotypes frequencies were expressed as percentages.Results
Out of 200 ‘O’ group blood donors, 96.5% were Rh D and 2.5% were K positive. Amongst Rh antigens, e was the most common (100%) followed by D, C (91.0%), c (50.5%) and E (16.5%) with DCe/DCe (R1R1, 48.0%) being the most common phenotype. In Kell blood group system, we found k antigen to be 100% and a rare phenotype Kp (a?+?b+) was found in 1% of the donors. For Kidd and Duffy blood group systems, Jk (a?+?b+) and Fy (a?+?b-) were the most common phenotypes (39.0% and 64.0%, respectively). In the MNS blood group system, M?+?N+ (67.5%) and S?+?s+(43.5%) were the most common phenotypes. There were antigens like Cw(3.5%), K(2.3%), Kpa(1.2%), Ina(1.0%), Vw(1.2%), Coa(4.5%), Cob(1%), Lua(1.75%), Dia+(1.2%), and Wra+(0.6%) with frequency < 5% in the donor population.Conclusion
Extensively antigen phenotypes group ‘O’ red cells showed significant variation with other population from India as well as with Caucasian and black population. Extensive phenotyping ‘O’ group regular blood donors of red cell antigens is very useful to prepare in-house red cell panels for identification of alloantibodies. 相似文献7.
Prasanna Mithra Prithvishree Ravindra B Unnikrishnan T Rekha Tanuj Kanchan Nithin Kumar Mohan Papanna Vaman Kulkarni Ramesh Holla K Divyavaraprasad 《Indian Journal of Palliative Care》2013,19(2):83-87
Background:
Organ transplantation is the most preferred treatment modality for end-stage organ diseases. The need for the transplants is higher than the availability. Prerequisites for the success of transplantation program include awareness and positive attitudes.Aim:
To assess the perceptions and attitudes of the people seeking health care in tertiary care centers towards organ donation in Mangalore, India.Settings and Design:
This cross-sectional study included 863 people seeking general healthcare as outpatients.Materials and Methods:
Face to face interviews were carried out using pretested tools which included the socio demographic data. Data was analyzed using Statistical Package for Social Sciences version 11.5.Results:
Overall, 59.6% participants showed the willingness to donate organs. Females (64.1%) and participants from upper socio economic status (62.7%) had higher willingness rates for organ donations. Hindus (63.6%) and Christians (63.3%) had higher willingness rates for organ donations than Muslims (38.2%). Also, 23.7% participants showed willingness to donate eyes and 33.6% wished to donate any organ after death. Most of the participants (67%) were aware that money should not be accepted for donating organs, and 58.1% were aware that it is an offence to accept any benefit for organ donations. Forty percent participants had perceived risks associated with organ donation. Regarding donor cards, 42.3% of the participants knew about it and 3.7% already possessed it.Conclusion:
It is apparent from the study that though there was high level of awareness about organ donation, a high proportion of the participants did not have positive attitudes towards organ donation. 相似文献8.
Yogesh Kumar Tailor Sarita Khandelwal Kanchan Verma Ram Gopal Mahendra Kumar 《RSC advances》2020,10(60):36713
Dispiroheterocycles have been synthesized by pseudo-four component reaction of 6-aminouracil/6-amino-2-thiouracil/2-amino-1,3,4-thiadiazole, p-toluidine and isatins in an ethanol–water mixture as solvent using β-cyclodextrin functionalized Fe3O4 nanoparticles as a magnetically separable and reusable heterogeneous catalyst. The nanocatalyst was synthesized and characterized by physicochemical characterization including Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD).An efficient and sustainable synthetic protocol has been presented for the synthesis of dispiroheterocycles using a magnetically separable and reusable nanostructured heterogeneous catalyst. 相似文献
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10.
Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses 总被引:2,自引:0,他引:2
Karlsson H Samarasinghe S Ball LM Sundberg B Lankester AC Dazzi F Uzunel M Rao K Veys P Le Blanc K Ringdén O Amrolia PJ 《Blood》2008,112(3):532-541
Mesenchymal stem cells (MSCs) suppress alloantigen-induced T-cell functions in vitro and infusion of third-party MSCs seems to be a promising therapy for graft-versus-host disease (GVHD). Little is known about the specificity of immunosuppression by MSCs, in particular the effect on immunity to pathogens. We have studied how MSCs affect T-cell responses specific to Epstein-Barr virus (EBV) and cytomegalovirus (CMV). We found that EBV- and CMV-induced proliferation and interferon- (IFN-) production from peripheral blood mononuclear cells (PBMCs) was less affected by third-party MSCs than the response to alloantigen and that MSCs had no effect on expansion of EBV and CMV pentamer-specific T cells. Established EBV-specific cytotoxic T cells (CTL) or CMV-CTL cultured with MSCs retained the ability to proliferate and produce IFN- in response to their cognate antigen and to kill virally infected targets. Finally, PBMCs from 2 patients who received MSCs for acute GVHD showed persistence of CMV-specific T cells and retained IFN- response to CMV after MSC infusion. In summary, MSCs have little effect on T-cell responses to EBV and CMV, which contrasts to their strong immunosuppressive effects on alloreactive T cells. These data have major implications for immunotherapy of GVHD with MSCs and suggest that the effector functions of virus-specific T cells may be retained after MSC infusion. 相似文献