全文获取类型
收费全文 | 1940篇 |
免费 | 135篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 99篇 |
妇产科学 | 105篇 |
基础医学 | 221篇 |
口腔科学 | 46篇 |
临床医学 | 186篇 |
内科学 | 540篇 |
皮肤病学 | 50篇 |
神经病学 | 57篇 |
特种医学 | 156篇 |
外科学 | 156篇 |
综合类 | 140篇 |
预防医学 | 103篇 |
眼科学 | 10篇 |
药学 | 94篇 |
1篇 | |
中国医学 | 74篇 |
肿瘤学 | 40篇 |
出版年
2021年 | 16篇 |
2018年 | 14篇 |
2017年 | 21篇 |
2016年 | 21篇 |
2015年 | 39篇 |
2014年 | 45篇 |
2013年 | 51篇 |
2012年 | 61篇 |
2011年 | 82篇 |
2010年 | 68篇 |
2009年 | 65篇 |
2008年 | 70篇 |
2007年 | 63篇 |
2006年 | 64篇 |
2005年 | 33篇 |
2004年 | 37篇 |
2003年 | 27篇 |
2002年 | 34篇 |
2001年 | 39篇 |
2000年 | 24篇 |
1999年 | 37篇 |
1998年 | 50篇 |
1997年 | 60篇 |
1996年 | 48篇 |
1995年 | 46篇 |
1994年 | 65篇 |
1993年 | 44篇 |
1992年 | 27篇 |
1991年 | 28篇 |
1990年 | 29篇 |
1989年 | 32篇 |
1988年 | 39篇 |
1987年 | 41篇 |
1986年 | 32篇 |
1985年 | 23篇 |
1984年 | 21篇 |
1983年 | 19篇 |
1982年 | 16篇 |
1981年 | 24篇 |
1980年 | 18篇 |
1977年 | 10篇 |
1959年 | 35篇 |
1958年 | 59篇 |
1957年 | 87篇 |
1956年 | 46篇 |
1955年 | 75篇 |
1954年 | 67篇 |
1953年 | 17篇 |
1952年 | 14篇 |
1949年 | 10篇 |
排序方式: 共有2088条查询结果,搜索用时 0 毫秒
1.
2.
Abstract: This paper dicusses the use of esophageal dilatation with a Rigiflex TTS balloon. This method was used 45 times on 11 patients affected by anastomotic or a severe grade peptic esophageal stenosis. Fluoroscopic guidance was used in 36 procedures (80%) without effecting the mean duration of the treatment (12 minutes). The results were considered satisfactory when these goals had been achieved: a) dilatation of the stenosis over 15 mm; b) a dysphagia free-time of more than 6 months. A satisfactory result was achieved in 10 patients (90.9%), without deaths and major complications. 5 patients received 1 dilatation and the other 5 needed, 3-3-4-7–11 procedures respectively to obtain a satisfactory result. On these basis we consider that its great efficacy, security and tolerability depend on the following characteristics of the Rigiflex TTS balloon: 1) “radial” dilatation; 2) the possibility of introducing the balloon through the operative channel of the fiberscope; 3) direct visualization of the stenosis during dilatation. The following disadvantages with this method are: the absence of a tactile sensation of dilatation and the elevated cost of the instrument. We conclude that the Rigiflex TTS balloon is an important alternative to guide-wire techniques, especially for the treatment of severe esophageal strictures. 相似文献
3.
4.
Anulus fibrosus in bulging intervertebral disks 总被引:1,自引:0,他引:1
In this investigation the association of radial tears of the anulus fibrosus and bulging of the intervertebral disk was studied. An index of disk bulging was measured in sagittal anatomic sections in 149 lumbar disks from 31 cadavers. The indexes of disk bulging were correlated with stages of disk development and the presence of an annular tear. The largest disk-bulging indexes were always associated with radial tears of the anulus. Eighty-four percent of the disks with radial tears had disk-bulging indexes greater than 2.5 mm. Most normal adult disks had an index of less than 2.5 mm. The results challenge the concept that the anulus fibrosus is intact in bulging disks, although ruptured in herniated disks. 相似文献
5.
We describe a patient with systemic lupus erythematosus and impaired renal function probably mainly due to tubulointerstitial disease. After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels. Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity. Neither our patient's clinical symptoms nor her serologic parameters improved possibly because of the low dosage and/or short duration of cyclosporine A treatment. We conclude that one should be cautious when treating patients with systemic lupus erythematosus and pre-existing renal disease with cyclosporine A especially when tubulointerstitial abnormalities are present and/or other nephrotoxic drugs are used. 相似文献
6.
7.
8.
Policosanol is a new cholesterol-lowering drug isolated and purified from sugar-cane wax. which prevents the development of lipofundin-induced lesions and foam-cell formation in New Zealand rabbits and Wistar rats. This study was conducted to examine the effects of policosanol on foam-cell formation in carrageenan-induced granulomas in rats. Eighteen Wistar rats were randomly distributed in three experimental groups which received orally for 20 days Tween 20 H2O as vehicle (control group) or policosanol at 2.5 or 25 mg kg?1. At the 11th day. lipofundin was injected intrapcritoneally for 8 days to induce formation of foam cells in the granuloma. At day 13, carrageenan was injected subcutaneously for granuloma induction and seven days later animals were killed. A significant reduction of the foam-cell formation in granulomas of policosanol-treated rats was observed. It is concluded that policosanol prevents the development of foam cells in carrageenan-induced granulomas (extravascular medium) in rats. 相似文献
9.
Twelve Sardinian patients affected by histologically defined classic Kaposi's sarcoma (KS) were HLA-A, B, C and DR typed. Compared to 220 age and ethnically matched healthy controls, KS patients showed a significant increase in HLA-DR5 (66.6 vs 23.1%, P less than 0.001) and a considerable decrease in HLA-DR3 (8.3 vs 53.6%, P = 0.0055). No definite association was observed for other HLA antigens. These results confirm the existence of an HLA associated genetic control of KS susceptibility and support the hypothesis that HLA-DR5 plays the role of a predisposition marker while HLA-DR3 bears a genetic resistance to the disease. 相似文献
10.
Reticuloendothelial Fc receptor function in SLE patients. I. Primary HLA linked defect or acquired dysfunction secondary to disease activity? 总被引:1,自引:5,他引:1 下载免费PDF全文
F J van der Woude M van der Giessen C G Kallenberg W Ouwehand H Beekhuis J M Beelen W J van Son P J Hoedemaeker G K van der Hem T H The 《Clinical and experimental immunology》1984,55(3):473-480
Reticuloendothelial system (RES) Fc receptor-mediated immune clearance was measured in 18 patients with systemic lupus erythematosus (SLE). Only two patients, with major disease activity, had a prolonged T 1/2 of the blood disappearance curve of injected IgG coated red cells in comparison to 22 healthy controls. Circulating immune complexes (CIC) were studied with three methods: PEG precipitation, C1q-ELISA and the indirect granulocyte phagocytosis test (IGFT). The T 1/2 of the blood disappearance curve related significantly to the IGFT (r = 0.55, P less than 0.05) and not to the PEG and C1q-ELISA test. Although HLA-DR3 phenotype frequency was significantly increased in our SLE population (P less than 0.05), it was not related to Fc receptor function. Similarly, HLA-DR2 phenotype was not related to RES Fc receptor function. These data do not support the concept that a genetic HLA linked defect in reticuloendothelial Fc receptor function is a primary cause of SLE, predisposing the inflicted individual to immune complex deposition. However, Fc receptor-mediated immune clearance seems to be related to disease activity itself and to levels of CIC. 相似文献