全文获取类型
收费全文 | 432篇 |
免费 | 6篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 9篇 |
基础医学 | 107篇 |
口腔科学 | 11篇 |
临床医学 | 98篇 |
内科学 | 60篇 |
皮肤病学 | 2篇 |
神经病学 | 21篇 |
特种医学 | 8篇 |
外科学 | 41篇 |
预防医学 | 19篇 |
眼科学 | 6篇 |
药学 | 27篇 |
中国医学 | 9篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 3篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2013年 | 5篇 |
2012年 | 8篇 |
2011年 | 18篇 |
2010年 | 7篇 |
2009年 | 9篇 |
2008年 | 18篇 |
2007年 | 14篇 |
2006年 | 8篇 |
2005年 | 17篇 |
2004年 | 8篇 |
2003年 | 15篇 |
2002年 | 13篇 |
2001年 | 8篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1993年 | 3篇 |
1992年 | 17篇 |
1991年 | 19篇 |
1990年 | 18篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 16篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 10篇 |
1972年 | 8篇 |
1971年 | 6篇 |
1970年 | 9篇 |
1969年 | 8篇 |
1968年 | 4篇 |
1967年 | 10篇 |
1966年 | 11篇 |
1965年 | 3篇 |
排序方式: 共有440条查询结果,搜索用时 15 毫秒
1.
Summary. Germline mutations of the RET proto-oncogene localized on chromosome 10q11.2 are the underlying cause of hereditary medullary
thyroid carcinoma. In MEN 2A and FMTC, mutations can be found in exons 10, 11, 13 or 14. MEN 2B is characterized by a specific
mutation in exon 16. In a significant number of sporadic MTC somatic mutations in codon 918 (exon 16) are detectable. Some
rare sporadic MTC present somatic mutations in codons 611, 634, 768 and 883. Recently, deletion-insertion of the RET proto-oncogene
in exon 11 and a deletion in exon 10 has been found. RET proto-oncogene mutations are not only responsible for the development
of the familial MTC, but may also play an important role in the pathogenesis of sporadic MTC. However, the prognostic relevance
of these somatic events is still unclear.
相似文献
2.
3.
4.
5.
6.
Sotnichenko BA Iordanova AS Kalinin OB Lemeshko IK 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2000,(6):13-15
The results of treatment of 63 injured persons with thoracicoabdominal trauma were analyzed. Injured persons with severe trauma and pronounced infringements of hemodynamic (41.25%); with severe injury of inferior organs and stable hemodynamical indexes (47.62%), light injury (11.12%) were detailed. Algorithm of curative-diagnostical measures for every group was elaborated. Among the injured persons 11 (17.46%) died. 相似文献
7.
Yogesh K Vashist Guentac Uzunoglu Guelle Cataldegirmen Viacheslar Kalinin Paulus Schurr Alexandra M Koenig Sabrina Thieltges Oliver Zehler Claus Schneider Jacob R Izbicki & Emre F Yekebas 《Histopathology》2009,54(3):303-308
Aims: Gastrointestinal stromal tumours (GISTs) display genetic alterations on chromosome 22. GTn repeat (GTn) length polymorphism in the promoter of haeme oxygenase-1 gene ( HMOX-1 ) is located on chromosome 22 and associated with malignant growth. The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients.
Methods and results: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival ( P = 0.001).
Conclusions: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST. 相似文献
Methods and results: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival ( P = 0.001).
Conclusions: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST. 相似文献
8.
9.
10.
To examine the distribution and physiological role of CO2/pH-sensitive chemoreceptors in the gills of the tropical fish, traira (Hoplias malabaricus), fish were exposed to acute environmental hypercarbia (1.25, 2.5 and 5.0% CO2 in air) and subjected to injections of HCl into the ventral aorta and buccal cavity. This was done before and after selective denervation of branchial branches of the IXth and Xth cranial nerves to various gills arches. Hypercarbia produced a significant decrease in heart rate, a mild hypotension as well as increases in both ventilation rate and ventilation amplitude. The data suggest that the hypercarbic bradycardia and increase in ventilation frequency arise from receptors exclusively within the gills but present on more than the first gill arch, while extra-branchial receptors may also be involved in controlling the increase in ventilation amplitude. With the exception of a decrease in heart rate in response to HCl injected into the ventral aorta, the acid injections (internal and external) did not mimic the cardiorespiratory responses observed during hypercarbia suggesting that changes in CO2 are more important than changes in pH in producing cardiorespiratory responses. Finally, the data indicate that chemoreceptors sensitive to CO2/pH and to O2 in the gills of this species involved in producing ventilatory responses are distributed in a similar fashion, but that those involved in producing the bradycardia are not. 相似文献