全文获取类型
收费全文 | 20331篇 |
免费 | 1304篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 122篇 |
儿科学 | 692篇 |
妇产科学 | 717篇 |
基础医学 | 2783篇 |
口腔科学 | 275篇 |
临床医学 | 3387篇 |
内科学 | 3749篇 |
皮肤病学 | 207篇 |
神经病学 | 2028篇 |
特种医学 | 302篇 |
外科学 | 1483篇 |
综合类 | 262篇 |
一般理论 | 32篇 |
预防医学 | 2843篇 |
眼科学 | 168篇 |
药学 | 1194篇 |
中国医学 | 13篇 |
肿瘤学 | 1414篇 |
出版年
2023年 | 91篇 |
2022年 | 165篇 |
2021年 | 340篇 |
2020年 | 216篇 |
2019年 | 381篇 |
2018年 | 400篇 |
2017年 | 283篇 |
2016年 | 363篇 |
2015年 | 406篇 |
2014年 | 604篇 |
2013年 | 978篇 |
2012年 | 1402篇 |
2011年 | 1407篇 |
2010年 | 774篇 |
2009年 | 764篇 |
2008年 | 1385篇 |
2007年 | 1346篇 |
2006年 | 1354篇 |
2005年 | 1382篇 |
2004年 | 1321篇 |
2003年 | 1291篇 |
2002年 | 1251篇 |
2001年 | 164篇 |
2000年 | 152篇 |
1999年 | 185篇 |
1998年 | 261篇 |
1997年 | 225篇 |
1996年 | 187篇 |
1995年 | 194篇 |
1994年 | 182篇 |
1993年 | 170篇 |
1992年 | 147篇 |
1991年 | 134篇 |
1990年 | 116篇 |
1989年 | 124篇 |
1988年 | 120篇 |
1987年 | 119篇 |
1986年 | 89篇 |
1985年 | 99篇 |
1984年 | 124篇 |
1983年 | 102篇 |
1982年 | 126篇 |
1981年 | 108篇 |
1980年 | 108篇 |
1979年 | 65篇 |
1978年 | 70篇 |
1977年 | 46篇 |
1976年 | 52篇 |
1975年 | 32篇 |
1974年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
2.
3.
4.
Judith Brock Andreas Schmid Thomas Karrasch Petra Pfefferle Jutta Schlegel Inga Busse Annette Hauenschild Barbara Schmidt Maria Koukou Efthymia Arapogianni Andreas Schultz Miriam Thomalla Secil Akinci Johannes Kruse Winfried Padberg Andreas Schffler Jens Albrecht 《Clinical endocrinology》2019,91(3):400-410
5.
Patients have become increasingly well informed with higher expectations to be involved in decision-making processes regarding their care and treatment. However, few studies have examined the impact of patient involvement on health care providers’ partnership-building communication. The aim of this study was to measure and explore the self-reported effects of patient involvement on the work of physicians and nurses. A questionnaire survey was distributed among cardiology staff in 12 Swedish hospitals (N = 488, response rate 67%). The sample was comprised of registered nurses (RNs, n = 303), licensed practical nurses (LPNs, n = 132), and physicians (MDs, n = 53). Confirmatory factor analysis was used to examine seven questionnaire statements concerning implications of patient involvement for one’s clinical work. Regression analyses were used to examine factors associated with staff’s partnership-building communication. Analysis confirmed two distinct factors accounting for 57% of the total variance, representing both negative—“Hassles”—and positive—“Uplifts”—aspects of patient involvement. Regression analyses revealed that only positive aspects (i.e., uplifts) of patient involvement predicted staff behavior aimed at involving patients. Working with actively involved patients may be a source of stress, both negative and positive, for health care professionals. By developing work routines for involving patients in their care, health care workplaces may help health care professionals to buffer the negative effects, and enhance the positive effects, of that stress. 相似文献
6.
7.
Implications for Practice
Breast cancer is far more curable than in the past but requires multimodality treatment. Great care must be taken to use the least leukemogenic treatment programs that do not sacrifice efficacy. Elimination of radiation and anthracycline/alkylating agent regimens will be helpful where possible, particularly in younger patients and possibly those with homologous repair deficiency (HRD). Use of colony-stimulating factors should be limited to those who truly require them for safe chemotherapy administration. Further study of a possible leukemogenic association with HRD and the various forms of colony-stimulating factors is badly needed.8.
9.
10.
Judith Bernardini Valerie Price Ana Figueiredo Aase Riemann Dora Leung 《Peritoneal dialysis international》2006,26(6):658-663
OBJECTIVE: To survey nurses around the world about current practices for peritoneal dialysis (PD) home training programs. DESIGN: Random sampling of nurses to complete a written survey from the International Society for Peritoneal Dialysis Nursing Liaison Committee. Settings: United States, Canada, South America (Brazil, Columbia), The Netherlands, Hong Kong. METHODS: Surveys and responses were sent by fax whenever possible, or by regular mail, or hand carried, or conducted by telephone. Results were stratified by geographic areas as well as by cumulative responses and were expressed as medians with ranges. Kruskal-Wallis was used to evaluate differences in responses. Associations between variables were tested with Pearson correlation. Univariate regression analysis was used to evaluate the impact of variables on peritonitis rates. Variables with p < 0.10 were included in a multivariate analysis. RESULTS: A total of 317 nurses responded: 88 in the United States, 46 in Canada, 58 in South America, 58 in Hong Kong, and 67 in The Netherlands. This represented 37% of all surveys distributed. Respondents had a median of 12 years' experience in nephrology (range 1-35 years), but only 31% had a formal background in adult education. Nearly half received their guidance to patient training from a nurse colleague, 11% were guided by a corporate colleague, and 8% were simply self-taught. Clinics responding had a median of 30 PD patients (range 1-400) and reported they trained a median of 8 patients per year (range 0-86). Reported peritonitis rates were a median 0.46 per year or 1 episode every 26 months. Peritonitis rates, however, were not known by 53% of respondents. Total training time per patient had a very wide range of hours, from 6 to 96. There was no correlation between training time and peritonitis rates among the study respondents (p = 0.38), nor with any other variables. CONCLUSIONS: There is wide variation in practices for PD patient training programs within countries and around the world. Training time did not appear to be related to peritonitis rates. Randomized trials of training practices are needed to determine which approaches produce the best outcomes for patients. 相似文献