全文获取类型
收费全文 | 2644篇 |
免费 | 230篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 75篇 |
妇产科学 | 21篇 |
基础医学 | 456篇 |
口腔科学 | 56篇 |
临床医学 | 257篇 |
内科学 | 600篇 |
皮肤病学 | 165篇 |
神经病学 | 190篇 |
特种医学 | 83篇 |
外科学 | 250篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 163篇 |
眼科学 | 94篇 |
药学 | 251篇 |
中国医学 | 1篇 |
肿瘤学 | 195篇 |
出版年
2023年 | 37篇 |
2022年 | 46篇 |
2021年 | 98篇 |
2020年 | 76篇 |
2019年 | 94篇 |
2018年 | 100篇 |
2017年 | 77篇 |
2016年 | 109篇 |
2015年 | 102篇 |
2014年 | 135篇 |
2013年 | 174篇 |
2012年 | 226篇 |
2011年 | 224篇 |
2010年 | 105篇 |
2009年 | 99篇 |
2008年 | 159篇 |
2007年 | 141篇 |
2006年 | 139篇 |
2005年 | 116篇 |
2004年 | 103篇 |
2003年 | 95篇 |
2002年 | 91篇 |
2001年 | 25篇 |
2000年 | 23篇 |
1999年 | 22篇 |
1998年 | 33篇 |
1997年 | 28篇 |
1996年 | 18篇 |
1995年 | 11篇 |
1994年 | 14篇 |
1993年 | 17篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 10篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1971年 | 5篇 |
1882年 | 2篇 |
1880年 | 9篇 |
1878年 | 7篇 |
排序方式: 共有2881条查询结果,搜索用时 15 毫秒
1.
Drug related hospital admissions 总被引:13,自引:0,他引:13
J. Hallas B. Harvald J. Worm J. Beck-Nielsen L. F. Gram E. Grodum N. Damsbo J. Schou H. Kromann-Andersen F. Frølund 《European journal of clinical pharmacology》1993,45(3):199-203
Summary As part of a high-intensity monitoring study of drug events as the cause of admission to departments of internal medicine, the effect of an educational intervention programme was studied. Two departments were included, one specialising in geriatrics and one that received patients by non-selected referral. The series consisted of 607 consecutive admissions studied before and 703 after the intervention. The drug events considered were adverse drug reactions and dose-related therapeutic failures, mainly due to non-compliance.A modest, statistically non-significant decrease in drug related hospital admissions (DRH) was seen, from 14% before to 13% after the intervention period. However, DRHs classified as definitely avoidable showed the significant decrease of 83%.There was no apparent relationship between the topics selected for the intervention programme and changes in the pattern of DRHs. No relationship between alterations in sales data and hospital admissions caused by a given drug could be demonstrated. A blinded external evaluation of case abstracts did not disclose any significant shift in the investigators' assessments.The intervention may have had an non-specific effect on avoidable DRHs. 相似文献
2.
3.
Jesper Carl Thomas Bro Christensen Hans von der Maase 《Acta oncologica (Stockholm, Sweden)》1992,31(7):749-753
This study presents an analysis on longitudinal tumour marker series in twenty-two patients with non-seminomatous germ cell cancers treated with cisplatinum (DDP) based combination chemotherapy. Series of alphafoetoprotein (AFP), human chorionic gonadotropin (HCG) and lactate dehydrogenase (LDH) were analyzed applying a dynamic mathematical marker model. The model analysis provided quantitated values for growth rate and treatment response in the marker producing cells. The analysis showed that LDH had to be above 2 000 U/l to be a trustworthy tumour marker. HCG producing cells tended to grow faster than AFP producing cells, and were 3-5-fold more sensitive to the chemotherapy given than AFP producing cells. Treatment response versus DDP dose appeared to be bi-phasic, but with no significant change in treatment efficiency within the given range of DDP doses. 相似文献
4.
Summary In Denmark it is legal to grow opium poppies for the production of poppy seeds and until 1986 for decoration purposes, too. Danish poppy capsules contain 0.3–5 mg morphine per capsule and the content of morphine in opium exuded from the capsules may amount to 24%. This has resulted in misuse as both fresh and dried poppy capsules have been used for the production of opium tea. During the period 1982–1985, seven casualties occurred among drug addicts in Denmark which were solely or partly caused by these opium poppies. 相似文献
5.
The cytokine lymphotoxin (LT)α is known to play a role in B cell activation. As the engagement of the B cell antigen CD40 is known to lead to B cell proliferation and differentiation, we studied LTα expression in human B cells after CD40 ligation. We demonstrate that anti-CD40 monoclonal antibody (mAb) induces strong LTα mRNA and surface expression in human tonsil B cells. Induction of LTα mRNA and surface expression by CD40 ligation is inhibited by the protein tyrosine kinase (PTK) inhibitors herbimycin and genistein in a dose-dependent manner. The protein kinase C (PKC)-specific inhibitors sphingosine and bisindolylmaleimide caused negligible inhibition of anti-CD40-induced LTα mRNA and surface expression. No inhibition is observed with the protein kinase (PKA) inhibitors H89 and HA1004. Cross-linking of the transmembrane phosphatase CD45 to CD40 by using goat-anti-mouse F(ab')2 fragments strongly inhibits CD40-mediated LTα expression in human B cells, confirming the role of PTK activation in CD40-mediated induction of LTα expression. Inhibitors of the serine/threonine protein phosphatases PP1 and PP2A, okadaic acid and calyculin induce LTα mRNA expression. In contrast, cyclosporin A, an inhibitor of the serine/threonine phosphatase calcineurin has no effect on anti-CD40-induced LTα expression. These results suggest that induction of LTα expression in B cells following engagement of CD40 involves activation of protein tyrosine kinases. 相似文献
6.
Verhaak CM Smeenk JM Evers AW van Minnen A Kremer JA Kraaimaat FW 《Journal of behavioral medicine》2005,28(2):181-190
The predictive value of a comprehensive model with personality characteristics, stressor related cognitions, coping and social support was tested in a sample of 187 nonpregnant women. The emotional response to the unsuccessful treatment was predicted out of vulnerability factors assessed before the start of the treatment. The results indicated the importance of neuroticism as a vulnerability factor in emotional response to a severe stressor. They also underlined the importance of helplessness and marital dissatisfaction as additional risk factors, and acceptance and perceived social support as additional protective factors, in the development of anxiety and depression after a failed fertility treatment. From clinical point of view, these results suggest fertility-related cognitions and social support should receive attention when counselling women undergoing IVF or ICSI treatment. 相似文献
7.
Pelin Sahlén Rapolas Spalinskas Samina Asad Kunal Das Mahapatra Pontus Höjer Anandashankar Anil Jesper Eisfeldt Ankit Srivastava Pernilla Nikamo Anaya Mukherjee Kyu-Han Kim Otto Bergman Mona Ståhle Enikö Sonkoly Andor Pivarcsi Carl-Fredrik Wahlgren Magnus Nordenskjöld Fulya Taylan Isabel Tapia-Páez 《The Journal of allergy and clinical immunology》2021,147(5):1742-1752
8.
9.
Jesper L. R. Andersson Anders Lilja P. Hartvig Bengt Långström Torsten Gordh Hermann Handwerker E. Torebjörk 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,117(2):192-199
Regional cerebral blood flow was measured with positron emission tomography (PET) in six healthy volunteers at rest and during
experimentally induced, sustained cutaneous pain on the dorsum of the right hand or on the dorsum of the right foot. Pain
was inflicted by intracutaneous injection of capsaicin, providing a mainly C-fibre nociceptive stimulus. Statistical analysis
showed significant activations along the central sulcus (SI) area when comparing pain in the hand to pain in the foot. Separate
comparison of both pain states to a baseline revealed different locations along the central sulcus for hand pain and foot
pain. The encountered differences are consistent with what is previously known about the somatotopics of non-painful stimuli.
When comparing painful stimuli to baseline, the contralateral anterior cingulate gyrus, the ipsilateral anterior insular cortex
and the ipsilateral prefrontal cortex were implicated. The results are consistent with an involvement of SI in the spatial
discrimination of acute cutaneous pain.
Received: 17 October 1996 / Accepted: 12 May 1997 相似文献
10.