全文获取类型
收费全文 | 710篇 |
免费 | 47篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 49篇 |
妇产科学 | 4篇 |
基础医学 | 89篇 |
口腔科学 | 16篇 |
临床医学 | 94篇 |
内科学 | 171篇 |
皮肤病学 | 16篇 |
神经病学 | 35篇 |
特种医学 | 134篇 |
外国民族医学 | 1篇 |
外科学 | 60篇 |
综合类 | 17篇 |
预防医学 | 20篇 |
眼科学 | 17篇 |
药学 | 54篇 |
中国医学 | 1篇 |
肿瘤学 | 18篇 |
出版年
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 9篇 |
2016年 | 9篇 |
2015年 | 6篇 |
2014年 | 14篇 |
2013年 | 21篇 |
2012年 | 22篇 |
2011年 | 15篇 |
2010年 | 27篇 |
2009年 | 29篇 |
2008年 | 12篇 |
2007年 | 44篇 |
2006年 | 13篇 |
2005年 | 15篇 |
2004年 | 8篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 13篇 |
1998年 | 43篇 |
1997年 | 33篇 |
1996年 | 39篇 |
1995年 | 26篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1992年 | 24篇 |
1991年 | 14篇 |
1990年 | 23篇 |
1989年 | 36篇 |
1988年 | 36篇 |
1987年 | 28篇 |
1986年 | 24篇 |
1985年 | 18篇 |
1984年 | 11篇 |
1983年 | 15篇 |
1982年 | 12篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1975年 | 5篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1969年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有802条查询结果,搜索用时 31 毫秒
1.
P Daloze C Des Rosiers R Arnoux T Daloze C Smeesters H Brunengraber 《The Journal of surgical research》1990,48(1):33-37
This report describes a technique for total hepatectomy in the dog. The procedure maintains the integrity of the gastrointestinal tract and the pancreas in the normothermic, anesthetized animal. The technique involves (i) a mesentericocaval shunt, (ii) a temporary external bypass between the femoral and jugular veins, and (iii) a permanent internal bypass between the abdominal and thoracic inferior vena cava through the tendinous area of the diaphragm. This 60- to 70-min procedure yields a preparation useful for short-term metabolic studies in nonhepatic tissues. 相似文献
2.
3.
We used arthrotomography to study the glenoid labrum in 114 patients. Sixty-nine of the patients had anatomic instability of the shoulder (including recurrent dislocation and subluxation of the shoulder), and 45 patients had functional instability of the shoulder (denoted by chronic pain, clicking of the joint, and the sensation that an unstable condition exists without the objective signs of it). Labral tears were revealed arthrotomographically in 86% of the patients with anatomic instability, while only 40% of the patients with functional instability had labral abnormalities, and these were primarily of minor severity. Fifty-six patients (44 of whom had anatomic instability; 12, functional instability) required surgery. The surgical findings were correlated with the arthrotomographic findings, and no false-positive results were revealed. However, arthrotomography demonstrated only part of the pathologic condition of two patients. These results confirm that there is a strong correlation between labral pathologic conditions and anatomic instability of the shoulder. Arthrotomographic studies have a great impact on the selection of therapy in cases of both anatomic and functional instability of the shoulder. 相似文献
4.
5.
Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group 总被引:5,自引:0,他引:5
Haines JL; Terwedow HA; Burgess K; Pericak-Vance MA; Rimmler JB; Martin ER; Oksenberg JR; Lincoln R; Zhang DY; Banatao DR; Gatto N; Goodkin DE; Hauser SL 《Human molecular genetics》1998,7(8):1229-1234
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the
central nervous system. While its etiology is not well understood, genetic
factors are clearly involved. Until recently, most genetic studies in MS
have been association studies using the case-control design testing
specific candidate genes and studying only sporadic cases. The only
consistently replicated finding has been an association with the HLA-DR2
allele within the major histocompatibility complex (MHC) on chromosome 6.
Using the genetic linkage design, however, evidence for and against linkage
of the MHC to MS has been found, fostering suggestions that sporadic and
familial MS have different etiologies. Most recently, two of four genomic
screens demonstrated linkage to the MHC, although specific allelic
associations were not tested. Here, a dataset of 98 multiplex families was
studied to test for an association to the HLA-DR2 allele in familial MS and
to determine if genetic linkage to the MHC was due solely to such an
association. Three highly polymorphic markers (HLA-DR, D6S273 and TNFbeta)
in the MHC demonstrated strong genetic linkage (parametric lod scores of
4.60, 2.20 and 1.24, respectively) and a specific association with the
HLA-DR2 allele was confirmed (TDT; P < 0.001). Stratifying the results
by HLA-DR2 status showed that the linkage results were limited to families
segregating HLA-DR2 alleles. These results demonstrate that genetic linkage
to the MHC can be explained by the HLA-DR2 allelic association. They also
indicate that sporadic and familial MS share a common genetic
susceptibility. In addition, preliminary calculations suggest that the MHC
explains between 17 and 62% of the genetic etiology of MS. This
heterogeneity is also supported by the minority of families showing no
linkage or association with loci within the MHC.
相似文献
6.
7.
Based on the dissection of 30 hemi-mandibles, the authors report a study of the inferior alveolar artery in its intraosseous course. On morphologic considerations they propose a classification of the collaterals into two groups: the principal collaterals destined for the teeth and the bony alveolar tissue and the secondary collaterals destined for the sheath and the nerve as well as the bony tissue around the canal. Loss of the teeth and absorption of the alveolar bone modify the caliber of the inferior alveolar arterial axis, the distribution of its collaterals and possibly its mode of termination. These facts suggest a consideration of the vascularization of the mandible in terms of four sectors. They arrive at practical conclusions that may be drawn from this study in stomatology. 相似文献
8.
9.
Cytofluorometric detection of human endothelial cells in whole blood using S-Endo 1 monoclonal antibody 总被引:9,自引:0,他引:9
F George P Poncelet J C Laurent O Massot D Arnoux N Lequeux P Ambrosi C Chicheportiche J Sampol 《Journal of immunological methods》1991,139(1):65-75
It has long been debated whether endothelial cells are present at very low frequency in peripheral blood. Elevated concentrations of such circulating cells may represent a good marker of vascular injury. We have therefore designed an immunocytometric assay for the detection of rare endothelial cells in whole blood. This assay is based on a new monoclonal antibody (MAb) S-Endo 1, made against human umbilical vein endothelial cells (HUVEC) and specific for endothelial cells of various origins without detectable reactivity with blood cells. First, the sensitivity of the assay was established by using normal blood samples with admixed HUVEC as an in vitro model. A good correlation was obtained between added and counted endothelial cells; the recovery was greater than 90% and the minimum detectable concentration of HUVEC was about 0.2 cells/microliters whole blood. Using this rapid counting technique, no detectable levels of endothelial cells were found in the blood of normal individuals (CE less than or equal to 0.1 cells/microliters) while elevated concentrations (up to 8 cells/microliters) were detected in a human model of vascular injury corresponding to a traumatic venepuncture. Thus, this new whole blood immunocytometric assay using S-Endo 1 MAb may be useful in determining the levels of circulating endothelial cells in vascular disorders. 相似文献
10.
Bernard Arnoux Jaqueline Durand Michel Rigaud B. Boris Vargaftig Jacques Benveniste 《Inflammation research》1981,11(6-7):555-556
Human, monkey and rat alveolar macrophages (AM) release PAF-acether in a dose-dependent fashion in the presence of 1 to 5 g/ml ionophore A 23187 (2.5 pmol of PAF-acether from 2.5×105 cells) but not in the presence of zymosan. Arachidonic acid (AA) metabolites released from AM from these species were studied. Thromboxane A2 TxA2)—detected by its action on rabbit arteries—was released from human, monkey and rat AM upon addition of 0.5 mM AA. This release was inhibited by aspirin and indomethacin. Lipoxygenase and cyclooxygenase AA metabolites from rat AM were identified using high efficiency glass capillary column gas chromatography coupled to mass spectrometry. The cyclooxygenase metabolites PGF2, E2 and D2 and TxB2 were identified. The lipoxygenase-dependent AA metabolites were explored using aspirin-pretreated AM. Only 12 HETE was found.These data indicate that AM secrete several substances with bronchoconstrictive activity: PGF2, D2, TxA2 and PAF-acether. Therefore an active role of AM in human and experimental bronchoconstriction must be considered. 相似文献