全文获取类型
收费全文 | 15767篇 |
免费 | 764篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 235篇 |
妇产科学 | 292篇 |
基础医学 | 1962篇 |
口腔科学 | 403篇 |
临床医学 | 1004篇 |
内科学 | 4044篇 |
皮肤病学 | 213篇 |
神经病学 | 1047篇 |
特种医学 | 645篇 |
外科学 | 2936篇 |
综合类 | 67篇 |
预防医学 | 392篇 |
眼科学 | 183篇 |
药学 | 1101篇 |
中国医学 | 59篇 |
肿瘤学 | 1935篇 |
出版年
2023年 | 56篇 |
2022年 | 111篇 |
2021年 | 259篇 |
2020年 | 156篇 |
2019年 | 192篇 |
2018年 | 234篇 |
2017年 | 219篇 |
2016年 | 251篇 |
2015年 | 258篇 |
2014年 | 348篇 |
2013年 | 446篇 |
2012年 | 704篇 |
2011年 | 825篇 |
2010年 | 431篇 |
2009年 | 416篇 |
2008年 | 747篇 |
2007年 | 807篇 |
2006年 | 791篇 |
2005年 | 816篇 |
2004年 | 904篇 |
2003年 | 884篇 |
2002年 | 867篇 |
2001年 | 488篇 |
2000年 | 497篇 |
1999年 | 518篇 |
1998年 | 240篇 |
1997年 | 210篇 |
1996年 | 199篇 |
1995年 | 170篇 |
1994年 | 127篇 |
1993年 | 106篇 |
1992年 | 284篇 |
1991年 | 227篇 |
1990年 | 256篇 |
1989年 | 296篇 |
1988年 | 285篇 |
1987年 | 262篇 |
1986年 | 244篇 |
1985年 | 239篇 |
1984年 | 144篇 |
1983年 | 134篇 |
1982年 | 62篇 |
1981年 | 57篇 |
1979年 | 114篇 |
1978年 | 75篇 |
1977年 | 59篇 |
1972年 | 53篇 |
1971年 | 56篇 |
1970年 | 50篇 |
1969年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Takaharu Negoro Kanami Orihara Tomoko Irahara Hiroshi Nishiyama Kanae Hagiwara Risa Nishida Hiroki Takagi Kazue Satoh Yoshiki Yamamoto Shunichi Shimizu Tamio Hagiwara Masakazu Ishii Toshihiro Tanioka Yasuko Nakano Ken Takeda Isao Yoshimura Yoji Iikura Takashi Tobe 《Pediatric allergy and immunology》2006,17(8):583-590
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor environment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity. 相似文献
5.
A variant of the HL-60 cell line, HL-60/MCSFR4D2, has been found to express twice the amount of PTP1C as compared to the parental HL-60 cell line by immunoblotting and immunoprecipitation. Differentiation of the variant cells after phorbol 12-myristate 13-acetate (PMA) treatment was examined by the appearance of adherence. In 1% fetal calf serum (FCS), 20% of HL-60/MCSFR4D2 cells exhibited adherence after treatment with 0.5 ng/ml PMA for 48 h, 60% exhibited adherence after treatment with 1.0 ng/ml PMA and 80% exhibited adherence after treatment with 5.0 ng/ml PMA, while HL-60 cells exhibited only a slight response. Furthermore, antisense PTP1C oligonucleotides decreased the PMA-induced adherence of HL-60/MCSFR4D2 cells. These results suggest that the high-expression of PTP1C in HL-60 cells may be involved in the enhancement of susceptibility to macrophage-like differentiation by PMA. 相似文献
6.
Beta2-glycoprotein I-dependent anticardiolipin antibody in early recurrent spontaneous abortion 总被引:1,自引:1,他引:0
Maejima M; Fujii T; Okai T; Kozuma S; Shibata Y; Taketani Y 《Human reproduction (Oxford, England)》1997,12(10):2140-2142
The objective of this study was to assess the clinical significance of
autoimmune anticardiolipin antibody that can react with cardiolipin only in
the presence of beta2-glycoprotein I (beta2-glycoprotein I- dependent
anticardiolipin antibody) in the pathogenesis of early recurrent abortion.
A total of 72 early recurrent spontaneous aborters and 175 normal healthy
women were analysed for the occurrence of beta2- glycoprotein I-dependent
anticardiolipin antibody in serum samples by an enzyme-linked immunosorbent
assay specific for the detection of beta2-glycoprotein I-dependent
anticardiolipin antibody. The incidence of beta2-glycoprotein I-dependent
anticardiolipin antibody in the early recurrent spontaneous aborters was
essentially the same as that of normal women. Thus, the beta2-glycoprotein
I-dependent anticardiolipin antibody seemed to have little, if any,
implication in the pathogenesis of early recurrent spontaneous abortion.
相似文献
7.
8.
Approach to early diagnosis of acute mesenteric ischemia: evaluation in canine model 总被引:1,自引:0,他引:1
K Kido A Maenosone N Takasu M Nishina K Tokuda C Fujii A Kohama 《Nihon Geka Gakkai zasshi》1986,87(10):1352-1358
The high mortality rate of patients with acute mesenteric ischemia may be mainly due to the difficulty of making an early diagnosis. Many clinical and experimental studies have been attempted to make an early diagnosis in the view of history, physical examination, laboratory data, X-rays and angiographies. This study was undertaken to estimate the diagnostic value of twenty one laboratory parameters and three clinical parameters measured after superior mesenteric artery occlusion (SMAO) in the mongrel dogs. Consequently, the valuable diagnostic indicators of SMAO that statistically had significant difference were serum CPK isoenzyme-BB, serum CPK isoenzyme-MB, serum inorganic phosphate, serum calcium and base excess of arterial blood gas analysis. In these indicators, serum CPK isoenzyme-BB, serum inorganic phosphate and serum calcium were especially valuable indicators of its early diagnosis, because they showed significant change in the early phase after SMAO. However, other indicators showed significant change within eighteen hours after SMAO. Therefore, if these indicators are able to be examined in a case of abdominal emergency, they are considered to play a valuable role in the diagnosis of acute mesenteric ischemia. 相似文献
9.
S Yamaguchi H Fujii S Kaneko S Yachiku F Inada T Anzai T Kobayashi K Furuta H Ishida 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1991,82(10):1561-1567
Ultrasonotomograms of 22 kidneys were obtained in 11 patients with renal-acute renal failure (renal-ARF). The underlying diseases of renal-ARF were acute tubular necrosis in 8 patients and acute on-set chronic glomerulonephritis in 3 patients. They were treated by hemodialysis in 10 patients and intermittent peritoneal dialysis in 1 patient. Ultrasonic measurement of the size of kidneys revealed that the thickness (anterior-posterior diameter) and the ratio of thickness to length (T/L) were greater in patients with ARF than in those with chronic renal failure and normal renal function. The patients with a low value of T/L (under 0.60) had a significantly greater urine volume than those with high a value of T/L (0.60 or more). The sonographic features of renal-ARF kidneys were marked increase in parenchymal echogenicity and appearance of hypoechoic swollen renal pyramids with sharpness of the corticomedullary border. In the course of ARF, these sonographic changes gradually disappeared when the patients had recovered from ARF. However, the prognosis was poor in patients with severer sonographic findings. We believe that repeated ultrasonic examination of the kidneys in patients with renal-ARF is useful for not only differential diagnosis of post-renal urinary obstruction but evaluating the course of ARF. 相似文献
10.