全文获取类型
收费全文 | 1612篇 |
免费 | 188篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 107篇 |
妇产科学 | 19篇 |
基础医学 | 144篇 |
口腔科学 | 48篇 |
临床医学 | 149篇 |
内科学 | 427篇 |
皮肤病学 | 33篇 |
神经病学 | 90篇 |
特种医学 | 204篇 |
外科学 | 148篇 |
综合类 | 103篇 |
预防医学 | 169篇 |
眼科学 | 8篇 |
药学 | 94篇 |
中国医学 | 3篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 22篇 |
2022年 | 15篇 |
2021年 | 42篇 |
2020年 | 31篇 |
2019年 | 18篇 |
2018年 | 28篇 |
2017年 | 51篇 |
2016年 | 50篇 |
2015年 | 51篇 |
2014年 | 91篇 |
2013年 | 100篇 |
2012年 | 60篇 |
2011年 | 56篇 |
2010年 | 78篇 |
2009年 | 82篇 |
2008年 | 50篇 |
2007年 | 94篇 |
2006年 | 57篇 |
2005年 | 42篇 |
2004年 | 50篇 |
2003年 | 32篇 |
2002年 | 28篇 |
2001年 | 52篇 |
2000年 | 30篇 |
1999年 | 33篇 |
1998年 | 83篇 |
1997年 | 69篇 |
1996年 | 62篇 |
1995年 | 52篇 |
1994年 | 46篇 |
1993年 | 43篇 |
1992年 | 14篇 |
1991年 | 9篇 |
1990年 | 19篇 |
1989年 | 24篇 |
1988年 | 27篇 |
1987年 | 17篇 |
1986年 | 22篇 |
1985年 | 18篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 11篇 |
1981年 | 4篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 5篇 |
1976年 | 13篇 |
1975年 | 10篇 |
1973年 | 3篇 |
排序方式: 共有1850条查询结果,搜索用时 15 毫秒
1.
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Daniel Coman Basavaraju G. Sanganahalli Lihong Jiang Fahmeed Hyder Kevin L. Behar 《NMR in biomedicine》2015,28(10):1257-1266
(+/?)3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) is an abused psychostimulant that produces strong monoaminergic stimulation and whole‐body hyperthermia. MDMA‐induced thermogenesis involves activation of uncoupling proteins (UCPs), primarily a type specific to skeletal muscle (UCP‐3) and absent from the brain, although other UCP types are expressed in the brain (e.g. thalamus) and might contribute to thermogenesis. Since neuroimaging of brain temperature could provide insights into MDMA action, we measured spatial distributions of systemically administered MDMA‐induced temperature changes and dynamics in rat cortex and subcortex using a novel magnetic resonance method, Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), with an exogenous temperature‐sensitive probe (thulium ion and macrocyclic chelate 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetramethyl‐1,4,7,10‐tetraacetate (DOTMA4?)). The MDMA‐induced temperature rise was greater in the cortex than in the subcortex (1.6 ± 0.4 °C versus 1.3 ± 0.4 °C) and occurred more rapidly (2.0 ± 0.2 °C/h versus 1.5 ± 0.2 °C/h). MDMA‐induced temperature changes and dynamics in the cortex and body were correlated, although the body temperature exceeded the cortex temperature before and after MDMA. Temperature, neuronal activity, and blood flow (CBF) were measured simultaneously in the cortex and subcortex (i.e. thalamus) to investigate possible differences of MDMA‐induced warming across brain regions. MDMA‐induced warming correlated with increases in neuronal activity and blood flow in the cortex, suggesting that the normal neurovascular response to increased neural activity was maintained. In contrast to the cortex, a biphasic relationship was seen in the subcortex (i.e. thalamus), with a decline in CBF as temperature and neural activity rose, transitioning to a rise in CBF for temperature above 37 °C, suggesting that MDMA affected CBF and neurovascular coupling differently in subcortical regions. Considering that MDMA effects on CBF and heat dissipation (as well as potential heat generation) may vary regionally, neuroprotection may require different cooling strategies. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
2.
3.
By injecting small amounts of CO2 through a needle, one can move bowel or bladder from the intended path of instruments during interventional procedures. The technique worked well in six of seven cases in the pelvis and retroperitoneum; it was not effective in the mediastinum or midabdomen (n = 6). 相似文献
4.
外科医生和手术室人员经常接触手术设备产生的烟气,病人也会暴露于烟气中,特别是腹腔镜手术中产生的烟气滞留于腹腔内这一密闭空间并被吸收.这些烟气是一种与香烟烟气相似的毒性物质,然而对这种毒性物质的影响还未引起足够重视.应该采取必要措施尽可能减少手术中烟气的不良影响. 相似文献
5.
6.
7.
8.
9.
10.