全文获取类型
收费全文 | 2278篇 |
免费 | 233篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 91篇 |
妇产科学 | 67篇 |
基础医学 | 301篇 |
口腔科学 | 22篇 |
临床医学 | 319篇 |
内科学 | 334篇 |
皮肤病学 | 29篇 |
神经病学 | 219篇 |
特种医学 | 99篇 |
外科学 | 239篇 |
综合类 | 62篇 |
一般理论 | 5篇 |
预防医学 | 264篇 |
眼科学 | 41篇 |
药学 | 159篇 |
中国医学 | 4篇 |
肿瘤学 | 253篇 |
出版年
2023年 | 17篇 |
2022年 | 22篇 |
2021年 | 75篇 |
2020年 | 37篇 |
2019年 | 57篇 |
2018年 | 61篇 |
2017年 | 42篇 |
2016年 | 63篇 |
2015年 | 67篇 |
2014年 | 76篇 |
2013年 | 103篇 |
2012年 | 179篇 |
2011年 | 137篇 |
2010年 | 86篇 |
2009年 | 80篇 |
2008年 | 106篇 |
2007年 | 111篇 |
2006年 | 105篇 |
2005年 | 100篇 |
2004年 | 113篇 |
2003年 | 93篇 |
2002年 | 92篇 |
2001年 | 50篇 |
2000年 | 32篇 |
1999年 | 55篇 |
1998年 | 46篇 |
1997年 | 37篇 |
1996年 | 25篇 |
1995年 | 23篇 |
1994年 | 18篇 |
1993年 | 17篇 |
1992年 | 29篇 |
1991年 | 26篇 |
1990年 | 38篇 |
1989年 | 36篇 |
1988年 | 17篇 |
1987年 | 12篇 |
1986年 | 15篇 |
1985年 | 22篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1982年 | 11篇 |
1981年 | 9篇 |
1979年 | 20篇 |
1978年 | 14篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1975年 | 9篇 |
1974年 | 9篇 |
1972年 | 9篇 |
排序方式: 共有2521条查询结果,搜索用时 15 毫秒
1.
2.
3.
Brain abscess in the 1980s 总被引:1,自引:0,他引:1
F E Donald J L Firth I M Holland D T Hope P Ispahani J A Punt 《British journal of neurosurgery》1990,4(4):265-271
Brain abscess was reviewed in 24 patients admitted to University Hospital, Nottingham over a period of 3 years. Chronic ear infection was the most common predisposing factor, but in 11 patients the focus of infection remained unknown. CT scanning, carried out in all patients, was negative in one patient with clinical signs of meningitis. Polymicrobial and anaerobic infections were common. Actinomyces species were isolated in mixed culture from seven patients; in five the abscess was located in the cerebellum. Therapy was most often a combination of surgical drainage and antimicrobial therapy with beta-lactam agents and metronidazole. Evidence suggests that cefotaxime may offer a suitable alternative to chloramphenicol and benzylpenicillin in the treatment of brain abscess. 相似文献
4.
The progressive degeneration of the brain seen in dementia is often accompanied by behavioural disturbances. Aggressive behaviour is one of the most serious of these disturbances and is a common cause for psychiatric referral, admission to hospital and drug treatment. In this article, we discuss the conceptual issues associated with defining aggressive behaviour in cognitively impaired patients. We then review the aetiology, epidemiology, methods of assessment, and management of aggressive behaviour in elderly people with dementia. 相似文献
5.
6.
We describe the types of aggressive behaviour and determine their prevalence in a sample of hospitalized elderly psychiatric patients. Data were obtained by nurse ratings of aggressive behaviour using the recently developed Rating Scale for Aggressive Behaviour in the Elderly; 90 patients were rated over a 3-d period. Nearly half the sample were at least mildly aggressive; the frequencies of some specific types of aggressive behaviour were high. In contrast, the frequency of injuries and the use of restraints and medication for aggressive behaviour were low. Some correlates of the aggressive behaviour were also analysed. 相似文献
7.
8.
Tony Hope Kathleen M. Tilling Kathy Gedling Janet M. Keene Sandra D. Cooper Christopher G. Fairburn 《International journal of geriatric psychiatry》1994,9(2):149-155
‘Wandering’ is one of the most troublesome of behavioural problems in dementia. The term ‘wandering’ covers many different types of behaviour. We examined the hypothesis that the different types of wandering behaviour seen in dementia from a scale using data collected on 83 elderly subjects suffering from either Alzheimer's disease or multiinfarct dementia. We reject the scaling hypothesis. Our data suggest that there are three main categories of wandering behaviour, and that one of these categories is usefully divided into four subcategories. 相似文献
9.
If I had not been asked to read this book, I would not havepicked it off the shelf, despite my interest in womenshealth. The two reasons for this were the cover and the title.Im ashamed to admit that A Life 相似文献
10.
CA von Arnim R Spoelgen ID Peltan M Deng S Courchesne M Koker T Matsui H Kowa SF Lichtenthaler MC Irizarry BT Hyman 《The Journal of neuroscience》2006,26(39):9913-9922
The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD). GGA1, a member of the Golgi-localized gamma-ear-containing ARF-binding (GGA) protein family, interacts with BACE and influences its subcellular distribution. We now report that overexpression of GGA1 in cells increased the APP C-terminal fragment resulting from beta-cleavage but surprisingly reduced Abeta. GGA1 confined APP to the Golgi, in which fluorescence resonance energy transfer analyses suggest that the proteins come into close proximity. GGA1 blunted only APP but not notch intracellular domain release. These results suggest that GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. GGA1 may act as a specific spatial switch influencing APP trafficking and processing, so that APP-GGA1 interactions may have pathophysiological relevance in AD. 相似文献