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排序方式: 共有62条查询结果,搜索用时 46 毫秒
1.
Chuang TW Hockett CW Kightlinger L Wimberly MC 《The American journal of tropical medicine and hygiene》2012,86(4):724-731
Understanding the landscape-level determinants of West Nile virus (WNV) can aid in mapping high-risk areas and enhance disease control and prevention efforts. This study analyzed the spatial patterns of human WNV cases in three areas in South Dakota during 2003-2007 and investigated the influences of land cover, hydrology, soils, irrigation, and elevation by using case-control models. Land cover, hydrology, soils, and elevation all influenced WNV risk, although the main drivers were different in each study area. Risk for WNV was generally higher in areas with rural land cover than in developed areas, and higher close to wetlands or soils with a high ponding frequency. In western South Dakota, WNV risk also decreased with increasing elevation and was higher in forested areas. Our results showed that the spatial patterns of human WNV risk were associated with landscape-level features that likely reflect variability in mosquito ecology, avian host communities, and human activity. 相似文献
2.
Anandakumar Amutha Pradeep A. Praveen Christine W. Hockett Toan C. Ong Elizabeth T. Jensen Scott P. Isom Ralph B. Jr. D'Agostino Richard F. Hamman Elizabeth J. Mayer‐Davis Raj Paul Wadwa Jean M. Lawrence Catherine Pihoker Michael G. Kahn Dana Dabelea Nikhil Tandon Viswanathan Mohan 《Pediatric diabetes》2021,22(1):31-39
3.
Christine W. Hockett Pradeep A. Praveen Toan C. Ong Anandakumar Amutha Scott P. Isom Elizabeth T. Jensen Ralph B. D'Agostino Richard F. Hamman Elizabeth J. Mayer‐Davis Jean M. Lawrence Catherine Pihoker Michael G. Kahn Viswanathan Mohan Nikhil Tandon Dana Dabelea 《Pediatric diabetes》2021,22(1):22-30
4.
The concept of cooperative processing within the context of a hospital or laboratory computer systems environment is introduced. Two examples that produce graphical display of laboratory data are described to illustrate cooperative processing's ability to enhance a system's functionality without placing significant additional burden on system resources. 相似文献
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Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues 总被引:1,自引:0,他引:1
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R. Pat Bucy Richard D. Hockett Cynthia A. Derdeyn Michael S. Saag Kathleen Squires Michael Sillers Ronald T. Mitsuyasu J. Michael Kilby 《The Journal of clinical investigation》1999,103(10):1391-1398
Previous studies proposed a dynamic, steady-state relationship between HIV-mediated cell killing and T-cell proliferation, whereby highly active antiretroviral therapy (HAART) blocks viral replication and tips the balance toward CD4(+) cell repopulation. In this report, we have analyzed blood and lymph node tissues obtained concurrently from HIV-infected patients before and after initiation of HAART. Activated T cells were significantly more frequent in lymph node tissue compared with blood at both time points. Ten weeks after HAART, the absolute number of lymphocytes per excised lymph node decreased, whereas the number of lymphocytes in the blood tended to increase. The relative proportions of lymphoid subsets were not significantly changed in tissue or blood by HAART. The expression levels of mRNA for several proinflammatory cytokines (IFN-gamma, IL-1beta, IL-6, and macrophage inflammatory protein-1alpha) were lower after HAART. After therapy, the expression of VCAM-1 and ICAM-1 -- adhesion molecules known to mediate lymphocyte sequestration in lymphoid tissue -- was also dramatically reduced. These data provide evidence suggesting that initial increases in blood CD4(+) cell counts on HAART are due to redistribution and that this redistribution is mediated by resolution of the immune activation that had sequestered T cells within lymphoid tissues. 相似文献
7.
T cell receptor gene deletion circles identify recent thymic
emigrants in the peripheral T cell pool 总被引:9,自引:0,他引:9
Fan-kun Kong Chen-lo H. Chen Adrien Six Richard D. Hockett Max D. Cooper 《Proceedings of the National Academy of Sciences of the United States of America》1999,96(4):1536-1540
Progenitor cells undergo T cell receptor (TCR) gene rearrangements during their intrathymic differentiation to become T cells. Rearrangements of the variable (V), diversity (D), and joining (J) segments of the TCR genes result in deletion of the intervening chromosomal DNA and the formation of circular episomes as a byproduct. Detection of these extrachromosomal excision circles in T cells located in the peripheral lymphoid tissues has been viewed as evidence for the existence of extrathymic T cell generation. Because all of the T cells in chickens apparently are generated in the thymus, we have employed this avian model to determine the fate of the V(D)J deletion circles. In normal animals we identified TCR Vγ-Jγ and Vβ-Dβ deletion circles in the blood, spleen, and intestines, as well as in the thymus. Thymectomy resulted in the gradual loss of these DNA deletion circles in all of the peripheral lymphoid tissues. A quantitative PCR analysis of Vγ1-Jγ1 and Vβ1-Dβ deletion circles in splenic γδ and Vβ1+ αβ T cells indicated that their numbers progressively decline after thymectomy with a half-life of approximately 2 weeks. Although TCR deletion circles therefore cannot be regarded as reliable indicators of in situ V(D)J rearrangement, measuring their levels in peripheral T cell samples can provide a valuable index of newly generated T cells entering the T cell pool. 相似文献
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9.
D A Miles W D McDavid U Welander S Hockett 《Oral surgery, oral medicine, and oral pathology》1986,62(1):92-95
Most comparisons between dental radiographs and dental xeroradiographs to date have been qualitative. Because the processing techniques and receptor materials are so dissimilar, a simple, objective comparison has been difficult. This report outlines a quantitative comparison technique that is easily reproduced. 相似文献
10.
Hendrix Cassandra L. Werchan Denise Lenniger Carly Ablow Jennifer C. Amstadter Ananda B. Austin Autumn Babineau Vanessa Bogat G. Anne Cioffredi Leigh-Anne Conradt Elisabeth Crowell Sheila E. Dumitriu Dani Elliott Amy J. Fifer William Firestein Morgan Gao Wei Gotlib Ian Graham Alice Gregory Kimberly D. Gustafsson Hanna Havens Kathryn L. Hockett Christine Howell Brittany R. Humphreys Kathryn L. Jallo Nancy King Lucy S. Kinser Patricia A. Levendosky Alytia A. Lonstein Joseph S. Lucchini Maristella Marcus Rachel Monk Catherine Moyer Sara Muzik Maria Nuttall Amy K. Potter Alexandra S. Rogers Cynthia Salisbury Amy Shuffrey Lauren C. Smith Beth A. Smyser Christopher D. Smith Lynne Sullivan Elinor Zhou Judy Brito Natalie H. Thomason Moriah E. 《Archives of women's mental health》2022,25(5):943-956
Archives of Women's Mental Health - Our primary objective was to document COVID-19 induced changes to perinatal care across the USA and examine the implication of these changes for maternal... 相似文献