全文获取类型
收费全文 | 1712篇 |
免费 | 97篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 68篇 |
妇产科学 | 26篇 |
基础医学 | 231篇 |
口腔科学 | 68篇 |
临床医学 | 149篇 |
内科学 | 403篇 |
皮肤病学 | 158篇 |
神经病学 | 72篇 |
特种医学 | 218篇 |
外科学 | 170篇 |
综合类 | 35篇 |
预防医学 | 99篇 |
眼科学 | 12篇 |
药学 | 47篇 |
中国医学 | 3篇 |
肿瘤学 | 58篇 |
出版年
2019年 | 13篇 |
2017年 | 17篇 |
2016年 | 18篇 |
2015年 | 24篇 |
2014年 | 28篇 |
2013年 | 71篇 |
2012年 | 24篇 |
2011年 | 33篇 |
2010年 | 55篇 |
2009年 | 63篇 |
2008年 | 28篇 |
2007年 | 36篇 |
2006年 | 37篇 |
2005年 | 38篇 |
2004年 | 25篇 |
2003年 | 17篇 |
2002年 | 29篇 |
2001年 | 27篇 |
2000年 | 24篇 |
1999年 | 30篇 |
1998年 | 89篇 |
1997年 | 76篇 |
1996年 | 80篇 |
1995年 | 54篇 |
1994年 | 69篇 |
1993年 | 56篇 |
1992年 | 24篇 |
1991年 | 29篇 |
1990年 | 43篇 |
1989年 | 52篇 |
1988年 | 49篇 |
1987年 | 41篇 |
1986年 | 30篇 |
1985年 | 32篇 |
1984年 | 29篇 |
1983年 | 19篇 |
1982年 | 23篇 |
1981年 | 23篇 |
1980年 | 15篇 |
1979年 | 21篇 |
1978年 | 15篇 |
1977年 | 21篇 |
1976年 | 21篇 |
1975年 | 14篇 |
1973年 | 28篇 |
1972年 | 16篇 |
1971年 | 15篇 |
1970年 | 12篇 |
1964年 | 12篇 |
1956年 | 12篇 |
排序方式: 共有1844条查询结果,搜索用时 62 毫秒
1.
2.
Infantile Digital Fibroma Treated With Mohs Micrographic Surgery 总被引:2,自引:0,他引:2
John G. Albertini MD Maj USAF MC Michael Jude Welsch MD CPT USA MC Leo A. Conger MD LTC USA MC Lester F. Libow MD COL USA MC Dirk M. Elston MD COL USA MC 《Dermatologic surgery》2002,28(10):959-961
BACKGROUND: Infantile digital fibroma (IDF) is a rare benign fibrous tumor of childhood that frequently recurs despite local excision. Conservative, nonsurgical management may result in regression and/or joint deformity. OBJECTIVE: To describe the histologic features of IDF and discuss a case excised using Mohs micrographic surgery (MMS). METHODS: Case report and review of the clinical, histologic, and ultrastructural features. RESULTS: Characteristic inclusion bodies of actin were identified with hematoxylin and eosin, Masson's trichrome, and rapid actin immunostain. The tumor was debulked and the majority was removed after one stage of MMS, except where the deep margin approached the joint space. The defect healed by secondary intention. At 2 years the patient had no recurrence or functional joint deformity. CONCLUSION: MMS is a surgical treatment option for IDF. 相似文献
3.
HJ Aubin S Tilikete C Laureaux HT Nguyen Hac MC Roullet-Volmi S Troupel D Barrucand 《European psychiatry》1995,10(8)
The aim of this study was to assess alcoholic inpatients' smoking and coffee intake variation following withdrawal. Only moderate smokers (less than 30 cigarettes/day) showed a significant increase of cigarette consumption after alcohol withdrawal. However, their urinary cotinine level did not vary, suggesting a behavioral, and not biological, compensation through smoking following alcohol withdrawal. Heavy smokers (30 cigarettes/day or more) showed no significant clinical or biological variation of smoking behavior. Coffee consumption increased after alcohol withdrawal in all patients, irrespective of smoking habits. 相似文献
4.
Xian ZH Zhang SH Cong WM Wu WQ Wu MC 《第二军医大学学报》2005,26(11):1320-1320
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent fatal cancers in the world. Despite advances in early diagnosis and improvements in surgical techniques, the survival of patients with HCC even after resection is poor because of the high incidence of recurrences. Therefore, the identification of prognostic factors may be helpful in the development of new treatment protocols. AIMS: To investigate HER-2/neu status in HCC by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and to explore the possibility of using trastuzumab in the treatment of HCC. METH ODS: Eight hundred and sixty eight surgical samples from patients with primary HCC were examined for their HER-2/neu status. IHC for HER-2/neu was performed with the HercepTest kit; FISH analysis was performed with the PathVysion HER-2 DNA probe kit. The correlations between HER-2/neu overexpression and clinicopathological characteristics were analysed statistically. RESULTS: HER-2/neu overexpression was detected in 21 (2.42%) of the 868 primary HCCs. Only one specimen showed HER-2/neu gene amplification by FISH. No significant associations were found between HER-2/neu overexpression and the clinicopathological parameters. CONCLUSIONS: There is a low frequency of HER-2/neu overexpression/amplification in HCC. There appears to be no role for HER-2/neu as a prognostic marker and no benefit of anti-HER-2/neu trastuzumab treatment in patients with HCC. 相似文献
5.
MC Brouard P Chavaz L Borradori 《Journal of the European Academy of Dermatology and Venereology》2004,18(1):89-92
BACKGROUND: Bowel-associated dermatosis-arthritis syndrome denotes the occurrence of diarrhoea with arthritis and skin lesions related to bowel disease with or without bowel bypass. In this condition, the histological finding of cutaneous aseptic neutrophilic cell infiltrate is non-specific and common to a wide spectrum of neutrophilic dermatoses, including pyoderma gangrenosum. OBSERVATION: We describe a 78-year-old woman with fever, abdominal discomfort and arthralgias, who developed grouped pustular lesions on her shins with histologically spongiform pustule formation. Aetiological assessment disclosed diverticular disease with sigmoid stenosis. CONCLUSION: Although clinical and histological features in our case fit the diagnosis of bowel-associated dermatosis-arthritis syndrome, they may also correspond to a pustular variant of pyoderma gangrenosum. Our observation raises the question of the nosological classification of bowel-associated dermatosis-arthritis syndrome within the spectrum of neutrophilic diseases. 相似文献
6.
7.
Victoria L. Herzberg 《Immunological investigations》1991,20(5):507-513
Serum, which is required for activation of T cells in vitro, was fractionated to isolate and identify major supportive components. The serum activity concentrated exclusively with the lipoprotein fractions LDL and HDL. Furthermore, oleic and linoleic acids were equally active supplements, suggesting that resting T cells may require exogenous lipid because they are incapable of synthesizing fatty acid. A survey of fatty acids disclosed that all were capable of some degree of support. Titration delineated the narrow concentration range of lipid supplements successful in supporting T cell proliferation and demonstrated that concentrations must be rigidly controlled to optimize cell proliferation. 相似文献
8.
The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis.
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M C Herzberg G D MacFarlane K Gong N N Armstrong A R Witt P R Erickson M W Meyer 《Infection and immunity》1992,60(11):4809-4818
A strain of Streptococcus sanguis that induced rabbit platelets to aggregate in vitro (Agg+ phenotype) was hypothesized to be a more virulent pathogen than an Agg- strain in experimental endocarditis in rabbits. A left ventricular catheter was implanted, and then an Agg+ or Agg- strain was inoculated intravenously. Vegetations formed on the aortic semilunar valves but were unaffected by the duration of implantation of the catheter. Vegetations enlarged by accumulating platelets and their mass increased directly with the duration of endocarditis. Inoculation of the Agg+ strain consistently caused endocarditis with significantly larger vegetations, a more severe clinical course (including febrile episodes, hematological changes, and signs of myocardial ischemia), more gross lesions in major organs, and greater mortality than inoculation with the Agg- strain, saline, or the Agg+ strain pretreated with monospecific rabbit immunoglobulin G or Fab fragments against its platelet aggregation-associated protein (PAAP; class II). In experimental endocarditis, PAAP expressed by Agg+ S. sanguis appeared to be an important virulence factor. 相似文献
9.
Krista Kupres DO Capt Usa MC Steven E. Rasmussen MD MAJ Usaf Fs MC John G. Albertini MD MAJ Usaf MC 《Dermatologic surgery》2002,28(5):388-389
BACKGROUND: Low cost, nonsterile examination gloves are used routinely to perform various dermatologic procedures. OBJECTIVE: To evaluate the perforation rate of nonsterile examination gloves in routine dermatologic procedures. METHODS: Three hundred fifty nonsterile latex examination gloves used to perform shave biopsies were evaluated for perforations using an air inflation/water submersion method. Ninety gloves, which were intentionally perforated with a 30-gauge needle, were used as controls to assess our evaluation method. RESULTS: Eight of the 350 gloves were found to have a perforation, which corresponds to a 2.3% perforation rate. Seven of the eight perforations were found in the web space between the second and third finger sleeves, with one being an obvious manufacturing error. All 90 perforations of the control group were correctly identified. CONCLUSION: There appears to be a very low risk of glove perforation when nonsterile examination gloves are used in routine dermatologic procedures. 相似文献
10.