全文获取类型
收费全文 | 7760篇 |
免费 | 535篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 312篇 |
妇产科学 | 125篇 |
基础医学 | 969篇 |
口腔科学 | 89篇 |
临床医学 | 739篇 |
内科学 | 1633篇 |
皮肤病学 | 105篇 |
神经病学 | 804篇 |
特种医学 | 350篇 |
外科学 | 1248篇 |
综合类 | 35篇 |
预防医学 | 529篇 |
眼科学 | 128篇 |
药学 | 581篇 |
中国医学 | 15篇 |
肿瘤学 | 638篇 |
出版年
2024年 | 14篇 |
2023年 | 95篇 |
2022年 | 121篇 |
2021年 | 199篇 |
2020年 | 168篇 |
2019年 | 211篇 |
2018年 | 260篇 |
2017年 | 233篇 |
2016年 | 216篇 |
2015年 | 259篇 |
2014年 | 329篇 |
2013年 | 430篇 |
2012年 | 619篇 |
2011年 | 634篇 |
2010年 | 316篇 |
2009年 | 290篇 |
2008年 | 486篇 |
2007年 | 499篇 |
2006年 | 507篇 |
2005年 | 413篇 |
2004年 | 408篇 |
2003年 | 373篇 |
2002年 | 372篇 |
2001年 | 57篇 |
2000年 | 44篇 |
1999年 | 60篇 |
1998年 | 72篇 |
1997年 | 59篇 |
1996年 | 56篇 |
1995年 | 53篇 |
1994年 | 40篇 |
1993年 | 46篇 |
1992年 | 30篇 |
1991年 | 28篇 |
1990年 | 23篇 |
1989年 | 23篇 |
1988年 | 21篇 |
1987年 | 22篇 |
1986年 | 27篇 |
1985年 | 21篇 |
1984年 | 13篇 |
1983年 | 31篇 |
1982年 | 19篇 |
1981年 | 21篇 |
1980年 | 12篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1967年 | 8篇 |
排序方式: 共有8346条查询结果,搜索用时 15 毫秒
1.
Signe S?nderkaer Marianne Schmiegelow Henrik Carstensen Lars B?geskov Nielsen J?rn Müller Kjeld Schmiegelow 《Journal of clinical oncology》2003,21(7):1347-1351
PURPOSE: To evaluate the pattern of neurological late effects in patients who have received surgery only for a brain tumor in childhood and to identify possible risk factors for neurological sequelae. PATIENTS AND METHODS: The medical, histologic, and operative records were reviewed for 65 consecutive patients operated for a benign brain tumor from 1970 to 1997, and all patients were re-examined after a median length of follow-up of 10.7 years. Thirty-four patients had posterior fossa tumors, 22 patients had cerebral hemisphere tumors, and nine patients had midline tumors. RESULTS: At the time of follow-up, 20 patients (31%) had no neurological deficits, 22 patients (34%) had minor deficits that did not interfere with their daily life activities, and 23 patients (35%) had moderate or severe deficits such as severe ataxia, spastic paresis, seriously reduced vision, or epilepsy with more than two seizures per year. Fourteen of the 31 patients (45%) registered with ataxia preoperatively had recovered fully. Six of seven patients had persistence of a pre- or postoperatively developed hemiparesis. Thirteen of 23 patients had persistence of cranial nerve deficits that developed second to surgery. Fifty-five percent of the 18 patients with seizures at diagnosis were seizure-free at follow-up. At follow-up both ataxia and hemiparesis were significantly more frequent among females (P =.02 and P =.03, respectively). CONCLUSION: In patients who received operation as the only treatment for their brain tumor, there was a good chance of total or partial recovery of preoperative and postoperative neurological deficits, although only one third of the patients will have no long-term neurological deficits. 相似文献
2.
Michael Larse Eva Hommel Hans-Henrik Parving Henrik Lund-Andersen 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1990,228(6):505-509
The effect of 18 months' inhibition of angiotensin-converting enzyme by captopril on the leakage of fluorescein through the blood-retina barrier was examined in a prospective, randomized control study of 20 normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy. After 18 months, 15 patients remained in the study. Fluorescein leakage remained nearly unchanged in the captopril-treated group, being 4.1 ± 4.1 (mean ± SD) × 10–7 cm/s at baseline and 4.2±4.1 × 10–7 cm/s after 18 months' treatment. The permeability increased significantly (P<0.01) from 3.3±2.2 × 10–7 cm/s to 5.6±3.5 × 10–7 cm/s at 18 months in the control group. Arterial blood pressure was nearly constant in both groups throughout the study. The results indicate that angiotensin-converting enzyme inhibition with captopril can arrest or delay a progressive breakdown of the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy.The authors have no commercial or proprietory interest in the drugs or instruments used in this study 相似文献
3.
Michael P Hill Erwan Bezard Steven G McGuire Alan R Crossman Jonathan M Brotchie Ann Michel Renee Grimée Henrik Klitgaard 《Movement disorders》2003,18(11):1301-1305
Long-term dopamine replacement therapy of Parkinson's disease leads to the occurrence of dyskinesias. Altered firing patterns of neurons of the internal globus pallidus, involving a pathological synchronization/desynchronization process, may contribute significantly to the genesis of dyskinesia. Levetiracetam, an antiepileptic drug that counteracts neuronal (hyper)synchronization in animal models of epilepsy, was assessed in the MPTP-lesioned marmoset model of Parkinson's disease, after coadministration with (1) levodopa (L-dopa) or (2) ropinirole/L-dopa combination. Oral administration of levetiracetam (13-60 mg/kg) in combination with either L-dopa (12 mg/kg) alone or L-dopa (8 mg/kg)/ropinirole (1.25 mg/kg) treatments was associated with significantly less dyskinesia, in comparison to L-dopa monotherapy during the first hour after administration. Thus, new nondopaminergic treatment strategies targeting normalization of abnormal firing patterns in basal ganglia structures may prove useful as an adjunct to reduce dyskinesia induced by dopamine replacement therapy without affecting its antiparkinsonian action. 相似文献
4.
5.
Marie-Louise Muff Christensen Umbreen Yousaf Gerda Engholm Hans Henrik Storm 《European journal of cancer prevention》2006,15(3):266-268
More suicides than expected (standardized mortality ratio=1.3; 95% confidence interval=1.1-1.6) compared to the population risk were found among Danish women with a diagnosis of non-melanoma skin cancer in the period 1971-1999 but not among men. The increased risk might be associated with a different personality type in this cancer group. 相似文献
6.
Torkel Falk Lennart J?nsson Lisbeth H Olsen Henrik D Pedersen 《Cardiovascular pathology》2006,15(4):185-193
BACKGROUND: The occurrence of small vessel arteriosclerosis in the myocardium, kidney, and lung in dogs with naturally occurring myxomatous mitral valve disease has not been previously investigated systematically. METHODS: Twenty-one dogs with naturally occurring congestive heart failure and 21 age-matched, sex-matched, and weight-matched control dogs underwent extensive pathological and histopathological examination. Morphometry and scoring of tissue sections were used to measure arterial narrowing and fibrosis in the myocardium, kidney, and lung; and intimal thickness and plaque formation in the aorta and pulmonary artery. RESULTS: Dogs with congestive heart failure had significantly more arterial narrowing in the left ventricle (P < .003), lung (P < .0001), and kidney (P < .02); intimal-medial thickening in the pulmonary artery (P = .04); and fibrosis in the left ventricle (P < .0001) than control dogs. However, they did not have more plaque formation or intimal-medial thickening in the aorta than controls. There was significantly more arterial narrowing in papillary muscles than in all other locations in dogs with congestive heart failure (P < .002). In control dogs, arterial changes were less pronounced and did not differ in different locations. CONCLUSIONS: Dogs with naturally occurring myxomatous mitral valve disease have significantly more arterial changes in the myocardium, lung, and kidney, and significantly more fibrosis in the myocardium than control dogs. This could have important implications in the management of myxomatous mitral valve disease and raises interesting questions about the occurrence and importance of intramural small vessel disease in humans with primary mitral valve prolapse. 相似文献
7.
Birgitte Lidegaard Frederiksen Merete Osler Henrik Harling Steen Ladelund Torben Jørgensen 《Social science & medicine (1982)》2009
This paper investigates the association between individually measured socioeconomic status (SES) and all-cause survival in colorectal cancer patients, and explores whether factors related to the patient, the disease, or the surgical treatment mediate the observed social gradient. 相似文献
8.
Background
Official guidelines that promote evidence-based and cost-effective prescribing are of main relevance for obvious reasons. However, to what extent these guidelines are followed and their conditioning factors at different levels of the health care system are still insufficiently known. 相似文献9.
Henrik Husted S ren Overgaard Jens Ole Laursen Klaus Hinds Lise N rrekjaer Hansen Harald M. Knudsen Niels B. Mossing 《Acta orthopaedica》1996,67(5):421-423
During the 10-year period 1981-1990, 1, 199 patients in the county of South Jutland, Denmark, had 1, 477 primary total hip arthroplasties (THA) performed because of primary arthrosis (OA).
The patients were followed until the end of 1994, with a mean follow-up of 5.6 (0-14) years. Bilateral operations were performed on 356 patients, whereas 248 patients had died with only 1 THA.
The cumulated risk of replacement of the contralateral hip was approximately 0.15 1 year after replacement of the first hip, 0.20 after 2 years, 0.29 after 5 years and 0.47 after 10 years, respectively.
During the follow-up period, the demand for a THA of the contralateral hip continued to be approximately 15 times higher than in the general population. 相似文献
The patients were followed until the end of 1994, with a mean follow-up of 5.6 (0-14) years. Bilateral operations were performed on 356 patients, whereas 248 patients had died with only 1 THA.
The cumulated risk of replacement of the contralateral hip was approximately 0.15 1 year after replacement of the first hip, 0.20 after 2 years, 0.29 after 5 years and 0.47 after 10 years, respectively.
During the follow-up period, the demand for a THA of the contralateral hip continued to be approximately 15 times higher than in the general population. 相似文献
10.