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排序方式: 共有142条查询结果,搜索用时 15 毫秒
1.
Parastoo Jangouk Thomas Dehmel Gerd Meyer Zu Hörste Andreas Ludwig Helmar C. Lehmann Bernd C. Kieseier 《Glia》2009,57(16):1765-1774
The disintegrin and metalloproteinase 10 (ADAM10) is a membrane‐anchored metalloproteinase with both proteolytic and disintegrin characteristics. Here, we investigate the expression, regulation, and functional role of ADAM10 in axonal outgrowth and myelination of the peripheral nerve. Expression pattern analysis of 11 ADAM family members in co‐cultures of rat dorsal root ganglia (DRG) neurons and Schwann cells (SCs) demonstrated the most pronounced mRNA expression for ADAM10. In further studies, ADAM10 was found to be consistently upregulated in DRG‐SC co‐cultures before the induction of myelination. Neurons as well as SCs widely expressed ADAM10 at the protein level. In neurons, the expression of ADAM10 was exclusively limited to the axons before the induction of myelination. Inhibition of ADAM10 activity by the hydroxamate‐based inhibitors GI254023X and GW280264X resulted in a significant decrease in the mean axonal length. These data suggest that ADAM10 represents a prerequisite for myelination, although its activity is not required during the process of myelination itself as demonstrated by expression analysis of myelin protein zero (P0) and Sudan black staining. Hence, during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve. © 2009 Wiley‐Liss, Inc. 相似文献
2.
Amir Kurtaran Josef Pfreitfellner Peter Schaffarich Peter Smith-Jones Bruno Niederle Markus Raderer Irene Virgolini Helmar Bergmann Ernst Havlik 《European journal of nuclear medicine and molecular imaging》1997,24(10):1298-1300
The purpose of this study was to estimate the radiation doses to nursing staff, other patients, accompanying persons and family
members deriving from patients undergoing 111In-DTPA-d-Phe-1-octreotide (111In-OCT) scintigraphy. Dose rates were measured from 16 patients who had received an intravenous injection of 140±40 MBq 111In-OCT. The measurements were performed at three different distances (0.5, 1 and 2 m) at 10–20 min, 5–7 h and 24 h (and in
some cases, up to 48 h) after administration of 111In-OCT. The effective half-lives of the biexponential decrease of the dose rates were estimated to be 2.94±0.27 h (T
1) and 65.17±0.58 h (T
2). The calculated maximum dose to other persons in the waiting area was 27.2 μSv, to family members 61.5 μSv, to nursing staff
in a ward 24.1 μSv and to neighbouring patients in the ward 69.5 μSv. Our results clearly demonstrate that the calculated
maximum radiation exposure to accompanying persons, personnel, family members and other patients is well below the maximum
annual dose limit for non-professionally exposed persons.
Received 20 May and in revised form 9 July 1997 相似文献
3.
Helmar Van Santen Zvonimir I. Kolar Robert F. Mudde Harry E. A. Van Den Akker 《Applied radiation and isotopes》1997,48(10-12)
In this paper the technique of cross-correlating the void fractions derived from the transmission signals of two γ-sources is used for the non-intrusive study of bubble phenomena in gas-solid fluidized beds. Special attention is given to the optimization of this method with respect to the statistical uncertainty inherent to radioactive decay. Experiments in a 40 cm gas-solid fluidized bed illustrate that bubble velocity distributions can be obtained. 相似文献
4.
Christian Ritter Martin K. R. Svačina Ilja Bobylev Abhijeet Joshi Toni Schneider Helmar C. Lehmann 《Journal of neuroimmune pharmacology》2017,12(1):204-209
Fingolimod is a an oral disease modifying drug for relapsing remitting multiple sclerosis (MS) preventing egress of B and T cells from lymph nodes. Relevant first dose adverse events include bradycardia and atrioventricular conduction slowing. Cardiac side effects of fingolimod and combinational pharmacotherapy including duloxetine and tolterodine were monitored in mice of different age using implantable ECG telemetric systems. Cardiac tissue was assessed for S1P-receptor subtype (1 and 3), and for GIRK1 expression. Fingolimod led to a significant heart rate reduction within 60 min, which returned to baseline values within 24 h. In older mice bradycardia was more pronounced compared to younger mice. Atrioventricular conduction was not affected. Older mice showed a higher S1PR3 expression in a naïve state and receptor expression was reduced after fingolimod administration. Combination with duloxetine or tolterodine alleviated fingolimod induced heart rate decrease. Our data provide preclinical evidence that negative chronotropic effects of fingolimod might be age dependent, possibly due to an altered expression and internalization of cardiac S1PR3 in older animals. This data could be relevant for future clinical monitoring and patient selection in the aging MS population. Combinational therapies of fingolimod and duloxetine or tolterodine are well tolerated and safe without an increased risk for pronounced bradycardia or arrhythmia. 相似文献
5.
Stacher G Lenglinger J Bergmann H Schneider C Brannath W Festa A Meghdadi S Stacher-Janotta G 《Digestive diseases and sciences》2003,48(6):1027-1034
Previous studies in diabetic patients suggested a relationship between delayed gastric emptying and increased ingesta retention in either proximal or distal stomach, but the determinants underlying these abnormalities remained obscure. We aimed at assessing the impact of cardiovascular autonomic neuropathy, blood glucose concentration, long-term glycemic control, and other factors in 34 type I and 43 type II diabetic patients (ages 21–67 and 34–81 years, respectively). Emptying was slower (P < 0.04) in type I diabetic patients than in 20 healthy control subjects (ages 23–63 years). Patients with autonomic neuropathy (N = 45) had slower gastric emptying (P < 0.02) and retained more in the distal stomach (P < 0.0001) than patients without neuropathy (N = 32). Multiple regression analyses revealed that slow emptying and increased distal retention were significantly associated with autonomic neuropathy (P < 0.043, P < 0.0002), whereas blood glucose, glycemic control, diabetes duration, age, and other factors had no discernible influence. Thus, both slow emptying and increased distal ingesta retention seem primarily referable to autonomic neuropathy. 相似文献
6.
Min-Chi Ku Susanne A. Wolf Dorota Respondek Vitali Matyash Andreas Pohlmann Sonia Waiczies Helmar Waiczies Thoralf Niendorf Michael Synowitz Rainer Glass Helmut Kettenmann 《Acta neuropathologica》2013,125(4):609-620
High-grade gliomas are the most common primary brain tumors. Their malignancy is promoted by the complex crosstalk between different cell types in the central nervous system. Microglia/brain macrophages infiltrate high-grade gliomas and contribute to their progression. To identify factors that mediate the attraction of microglia/macrophages to malignant brain tumors, we established a glioma cell encapsulation model that was applied in vivo. Mouse GL261 glioma cell line and human high-grade glioma cells were seeded into hollow fibers (HF) that allow the passage of soluble molecules but not cells. The glioma cell containing HF were implanted into one brain hemisphere and simultaneously HF with non-transformed fibroblasts (controls) were introduced into the contralateral hemisphere. Implanted mouse and human glioma- but not fibroblast-containing HF attracted microglia and up-regulated immunoreactivity for GFAP, which is a marker of astrogliosis. In this study, we identified GDNF as an important factor for microglial attraction: (1) GL261 and human glioma cells secret GDNF, (2) reduced GDNF production by siRNA in GL261 in mouse glioma cells diminished attraction of microglia, (3) over-expression of GDNF in fibroblasts promoted microglia attraction in our HF assay. In vitro migration assays also showed that GDNF is a strong chemoattractant for microglia. While GDNF release from human or mouse glioma had a profound effect on microglial attraction, the glioma-induced astrogliosis was not affected. Finally, we could show that injection of GL261 mouse glioma cells with GDNF knockdown by shRNA into mouse brains resulted in reduced tumor expansion and improved survival as compared to injection of control cells. 相似文献
7.
Kovalevska Kateryna Bornemann-Cimenti Helmar Hochsttter Rdiger Augustin Michael Schittek Gregor Alexander 《Der Anaesthesist》2022,71(9):722-723
Die Anaesthesiologie - 相似文献
8.
Teixeira da Silva Jaime A. Bornemann-Cimenti Helmar Tsigaris Panagiotis 《Medicine, health care, and philosophy》2021,24(1):21-26
Medicine, Health Care and Philosophy - Retractions of COVID-19 literature in both preprints and the peer-reviewed literature serve as a reminder that there are still challenging issues underlying... 相似文献
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