全文获取类型
收费全文 | 350篇 |
免费 | 20篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 5篇 |
基础医学 | 89篇 |
口腔科学 | 11篇 |
临床医学 | 35篇 |
内科学 | 34篇 |
皮肤病学 | 16篇 |
神经病学 | 22篇 |
特种医学 | 5篇 |
外科学 | 54篇 |
预防医学 | 49篇 |
眼科学 | 5篇 |
药学 | 22篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 5篇 |
2014年 | 4篇 |
2013年 | 7篇 |
2012年 | 17篇 |
2011年 | 20篇 |
2010年 | 8篇 |
2009年 | 9篇 |
2008年 | 18篇 |
2007年 | 14篇 |
2006年 | 16篇 |
2005年 | 10篇 |
2004年 | 20篇 |
2003年 | 12篇 |
2002年 | 22篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 8篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1940年 | 1篇 |
1914年 | 1篇 |
排序方式: 共有370条查询结果,搜索用时 15 毫秒
1.
2.
3.
Expression of epithelial adhesion proteins and integrins in chronic inflammation. 总被引:4,自引:1,他引:4 下载免费PDF全文
K. Haapasalmi M. Mkel O. Oksala J. Heino K. M. Yamada V. J. Uitto H. Larjava 《The American journal of pathology》1995,147(1):193-206
Epithelial cell behavior in chronic inflammation is poorly characterized. During inflammation of tooth-supporting structures (periodontal disease), increased proliferation of epithelial cells into the inflamed connective tissue stroma is commonly seen. In some areas ulceration and degeneration take place. We studied alterations in the expression of adhesion molecules and integrins during chronic periodontal inflammation. In inflamed tissue, laminin-1 and type IV collagen were still present in the basement membrane and surrounding blood vessels, but they were also found extravascularly in inflamed connective tissue stroma. Type VII collagen and laminin-5 (also known as kalinin, epiligrin, or nicein) were poorly preserved in the basement membrane zone, but both were found in unusual streak-like distributions in the subepithelial connective tissue stroma in inflamed tissue. Both fibronectin and tenascin were substantially decreased in chronically inflamed connective tissue, showing only punctate staining at the basement membrane zone. Integrins of the beta 1 family showed two distinct staining patterns in epithelial cells during chronic inflammation; focal losses of beta 1 integrins (alpha 2 beta 1 and alpha 3 beta 1) were found in most areas, while in other areas the entire pocket epithelium was found to be strongly positive for beta 1 integrins. No members of the alpha v integrin family were found in any epithelia studied. Expression of the alpha 6 beta 4 integrin was high in basal cells of healthy tissue, but weak in epithelium associated with chronic inflammation. Chronic inflammation therefore involves alterations in both adhesion proteins and integrins expressed by epithelial cells. Basement membrane components found at abnormal sites in stroma in chronic inflammation might serve as new adhesive ligands for various cell types in inflamed stroma. 相似文献
4.
5.
M. Jalkanen H. Larjava J. Heino T. Vihersaari J. Peltonen R. Penttinen 《Immunology letters》1982,4(5):259-261
In the present work we demonstrate that non-activated, cultured rat peritoneal macrophages deplete arginine from their culture medium and that the use of this medium in fibroblast cultures may lead to decreased synthesis of collagen by fibroblasts. 相似文献
6.
7.
Hendro Pranoto Franz-Josef Bormuth Wolfgang Haase Ulrich Kiechle Heino Finkelmann 《Macromolecular chemistry and physics.》1986,187(10):2453-2460
An investigation on the molecular dynamics of a liquid crystalline side chain polymer using the dielectric relaxation method on oriented samples in the frequency range of 0,1 to 10 000 kHz is presented. The compound under investigation is a polysiloxane copolymer with two different mesogenic side chains and a phase sequence glassy-smectic A-nematic-isotropic. Three main relaxation processes are found and assigned to the rotation of the side chains around the main chain, the glass transition process coupled with side chain motions, and a local motion in the glassy state, respectively. Evidence is found for a layered arrangement of the polymer main chain in the smectic phase and for a parallel correlation between the transverse components of the dipole moments. 相似文献
8.
Heino JG Godges JJ Carter CL 《The Journal of orthopaedic and sports physical therapy》1990,12(6):243-247
The purpose of this study was to examine the relationships between hip extension range of motion (ROM) and three determinants of postural alignment: standing pelvic tilt, standing lumbar lordosis, and abdominal muscle performance. The subjects were 25 healthy adults ranging in age from 21 to 49 years. The Pearson product-moment correlation of hip extension ROM with pelvic tilt was -0.04, with lumbar lordosis -0.09, and with abdominal muscle performance 0.09. These results indicate that these variables are not related. This study demonstrates that the hypothetical correlation among these clinical parameters needs to be reassessed. J Orthop Sports Phys Ther 1990;12(6):243-247. 相似文献
9.
The aim of the present study was to examine the expression of 1 integrin subunit after peripheral nerve transection. After sciatic nerve transection two experimental procedures were used; changes in the freely regenerating rat sciatic nerve were compared to a situation in which spontaneous regeneration was prevented by suturing both ends of the nerve to the muscle next to the point of transection. Specimens for morphological analysis were collected 6 h, 1, 3, 5, 7 days and 2, 4, 6 and 8 weeks after the axotomy. Sections from the proximal (two zones) and distal (three zones) stumps next to the point of transection were stained with antibodies against 1 integrin subunit, macrophages, collagen types I and III, and S-100 protein. The control nerves showed 1 integrin-stained cells in the perineurium and vasa nervorum but the endoncurium was negative. Positively stained endoneurial fibroblast-like cells could be seen in the proximal part of the nerve already at 24 h after transection. The number of these positively stained cells increased steadily; they were most numerous 4 weeks after transection in the distal zone 2. Subsequently, the number of positively stained endoneural cells declined sharply and 8 weeks after transection no positively stained cells could be found. The morphological appearance and the immunohistochemical properties of the cells suggest that the majority of 1 integrin-positive cells are endoneurial fibroblast-like cells. Thus, the process appeared to be dynamic, starting from the proximal part and continuing to the distal parts, and was similar in both experimental groups. The positive staining in perineurial cells indicate that 1 integrin, which is an important mediator of the cell-matrix interaction, may have an essential role in the formation and strengthening of the normal peripheral nerve structures. Furthermore, 1 integrin seems to have an active role in reactions which occur during the early phases of peripheral nerve regeneration. 相似文献
10.