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1.
Nucleotide sequence analysis of the 4.3 kbp BamHI-N fragment of the fowlpox virus (FPV) genome revealed that it encodes 7
proteins with homology to vaccinia virus (VV) E11L, E10R, O1L, O3L, I1L, I2L and I3L encoded proteins. No evidence of FPV
homolog of VV O2L could be found.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
2.
F M Brett D Costigan M A Farrell P Heaphy J Thornton M D King 《European journal of paediatric neurology》1998,2(2):77-82
Congenital muscular dystrophy (CMD) encompasses a heterogenous group of muscle disorders with autosomal recessive inheritance, characterized by muscular weakness and hypotonia at birth or within the first few months of life and developmental delay. Merosin-deficient CMD is a clinically distinct form which may be associated with significant abnormalities of the brain detectable by neuroimaging. We report two siblings of consanguineous parents with merosin-deficient CMD in an Irish family who in addition to the characteristic white matter abnormalities on neuroimaging, had occipital dysplasia. Clinical, electrophysiological muscle biopsy findings and neuroimaging were very similar in both cases. Although merosin-deficient CMD with white matter abnormalities on neuroimaging is well documented in the literature, the association with occipital dysplasia has only rarely been reported. The appearance of an identical cortical defect in these siblings suggests an underlying genetic mechanism. 相似文献
3.
Ahmed S. Bahaj Haddad H. Alkaff Bashair N. Melebari Anwar N. Melebari Suhail I. Sayed Syeddah S. Mujtaba Sherif K. Abdelmonim Saeed A. Alghamdi Fares E. Alghamdi Omar A. Abu Suliman Mohammad A. Alessa Firas R. Abi Sheffah Anas H. Al-Tammas Rajab A. Al-Zahrani Osama A. Marglani John C. Heaphy Osama A. Bawazir Ameen Z. Alherabi 《Saudi medical journal》2020,41(10):1098
Objectives:To evaluate the accuracy and efficacy of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules, correlating it with the histopathological findings.Methods:A retrospective evaluation of 314 patients was undertaken at a tertiary referral center of King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia, between 2010-2019. Patients who presented with thyroid swellings underwent ultrasonography and FNAC. If indicated, surgery was performed. The FNAC findings were compared to the final histopathological reports.Results:The findings for FNAC from our data set of 314 patients showed a sensitivity value of 79.8%, specificity of 82.1%, accuracy of 74.8%, positive predictive value of 74.8%, and negative predictive value of 85.9%.Conclusion:Our study showed that FNAC has high sensitivity and specificity in the initial evaluation of patients with thyroid nodules. When guided by ultrasonography, the accuracy can be markedly improved. Molecular markers once widely available can improve the diagnostic power of FNAC to be no less than the histopathologic evaluation of thyroid tissue. 相似文献
4.
Haddad H. Alkaff Bayan O. Besharah Deemah H. Bukhari Suhail I. Sayed Mohammad A. Alessa Sherif K. Abdelmonim Saeed A. Alghamdi Fares E. Alghamdi Omar A. Abu Suliman Firas R. Abi Sheffah Anas H. Al-Tammas Rajab A. Al-Zahrani Osama A. Marglani John C. Heaphy Osama A. Bawazir Ameen Z. Alherabi 《Saudi medical journal》2020,41(12):1330
5.
E. L. G. Heaphy D. A. Goldfarb E. D. Poggio L. D. Buccini S. M. Flechner J. D. Schold 《American journal of transplantation》2013,13(4):1001-1011
As of May 2012, over 92 000 patients were awaiting a solitary kidney transplant in the United States and new waitlist registrations have been rising for over a decade. The decreasing availability of donor organs makes it imperative that organ allocation be as efficient and effective as possible. We performed a retrospective cohort study of adult recipients in the United States (n = 109 392) using Scientific Registry of Transplant Recipients data. The primary aim was to evaluate the interaction of donor risk with recipient characteristics on posttransplant outcomes. Donor quality (based on kidney donor risk index [KDRI]) had significant interactions by race, primary diagnosis and age. The hazard of KDRI on overall graft loss in non‐African Americans was 2.16 (95%CI 2.08‐2.25) versus 1.85 (95%CI 1.75‐1.95) in African Americans (p < 0.0001), 2.16 (95%CI 2.08‐2.24) in nondiabetics versus 1.84 (95%CI 1.74‐1.94) in diabetics (p < 0.0001), and 2.22 (95%CI 2.13‐2.32) in recipients <60 years versus 1.83 (95%CI 1.74‐1.92) in recipients ≥60 (p < 0.0001). The relative hazard for diabetics at KDRI = 0.5 was 1.49 but at KDRI = 2.0 the hazard was significantly attenuated to 1.17; among African Americans the respective risks were 1.50 and 1.17 and among recipients 60 and over, it was between 1.64 and 1.22. These findings are critical considerations for informed decision‐making for transplant candidates. 相似文献
6.
Fordyce CA Heaphy CM Joste NE Smith AY Hunt WC Griffith JK 《The Journal of urology》2005,173(2):610-614
PURPOSE: We evaluated the hypothesis that telomere DNA content (TC) in prostate tumor tissue is associated with time to prostate cancer recurrence. MATERIALS AND METHODS: The cohort was comprised of 77 men who underwent prostatectomy between 1982 and 1995. Slot blot assay was used to measure TC in DNA extracted from paraffin embedded tumor and nearby, histologically normal prostate (NHN) tissues. Multivariate Cox proportional hazards analysis was done to relate TC, patient age at diagnosis, Gleason sum and pelvic node involvement to time of prostate cancer recurrence. Regression analysis was done to relate TC in paired tumor and NHN tissues. Nonparametric Kruskal-Wallis analysis was done to relate TC in tumor and NHN tissues with 72-month disease-free survival. RESULTS: TC was a predictor of time to prostate cancer recurrence when controlling for age at diagnosis, Gleason sum and pelvic node involvement (RH = 5.02, 95% CI 1.40 to 17.96, p = 0.0132). TC in tumor tissue was associated with TC in NHN tissue (R = 0.601, p <0.0001). Median TC in tumor and NHN tissues from men in whom cancer recurred within 6 years was approximately half that in men who remained disease-free (p = 0.012 and 0.024, respectively). CONCLUSIONS: Decreased TC in prostate tissues obtained by radical prostatectomy predicts prostate cancer recurrence independent of age at diagnosis, Gleason sum and pelvic node involvement. TC in tumor tissue is also associated with TC in NHN prostate tissue. Thus, mechanisms known to generate genomic instability are operative in fields of cells beyond the tumor margins prior to histological changes. 相似文献
7.
8.
Emily L. G. Heaphy Sana Loue 《Journal of immigrant and minority health / Center for Minority Public Health》2010,12(1):74-82
Renewed interest has been expressed by researchers in mixed-method assessment that employs both quantitative and qualitative
techniques in an expansive style that utilizes a variety of tactics to address research questions. Participants consisted
of Puerto Rican women with severe mental illness living in Cuyahoga County, Ohio. The women were shadowed over a 2-year period
to observe and verify behaviors that were self-reported using standardized instruments in semi-structured interviews. Concurrent
criterion-related validity was employed to determine the extent of the correlation between responses obtained from the two
approaches. Forty-four percent of the women were diagnosed with major depression and the mean overall GAF score was 58.5 ± 14.5.
A comparison of the data collected using the different methodologies revealed that inconsistent and contradictory responses
are not uncommon. The mixed-method design provided a more complete way of obtaining HIV-risk behavior data. Researchers and
clinicians could benefit from mixed methods research that can provide greater opportunities to obtain data of a sensitive
nature. 相似文献
9.
Eva Shrestha Jonathan B. Coulter William Guzman Busra Ozbek Megan M. Hess Luke Mummert Sarah E. Ernst Janielle P. Maynard Alan K. Meeker Christopher M. Heaphy Michael C. Haffner Angelo M. De Marzo Karen S. Sfanos 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(32)
10.
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro. 总被引:30,自引:2,他引:30 下载免费PDF全文
C Dingwall I Ernberg M J Gait S M Green S Heaphy J Karn A D Lowe M Singh M A Skinner R Valerio 《Proceedings of the National Academy of Sciences of the United States of America》1989,86(18):6925-6929
tat, the trans-activator protein for human immunodeficiency virus 1 (HIV-1), has been expressed in Escherichia coli from synthetic genes. Purified tat binds specifically to HIV-1 trans-activation-responsive region (TAR) RNA in gel-retardation, filter-binding, and immunoprecipitation assays. tat does not bind detectably to antisense TAR RNA sequences, cellular mRNA sequences, variant TAR RNA sequences with altered stem-loop structures, or TAR DNA. 相似文献