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1.
1. Mammalian taste receptors are distributed within several distinct subpopulations, innervated by branches of cranial nerves VII, IX, and X. Most gustatory electrophysiology has focused on input from the fungiform papillae on the anterior portion of the tongue, carried by the chorda tympani branch of the VIIth nerve. However, laryngeal taste buds in the hamster are as numerous as those in the fungiform papillae. Gustatory fibers in the hamster's chorda tympani and glossopharyngeal nerves have been well characterized. In comparison with these taste fibers, much less is known about the chemical sensitivities of fibers innervating laryngeal taste buds. 2. Action potentials were recorded from 65 individual fibers in the superior laryngeal nerve (SLN) of the hamster. Stimuli were distilled H2O and five concentrations each of sucrose, NaCl, HCl, and quinine hydrochloride (QHCl). All stimuli except the NaCl series were made in physiological saline (0.154 M NaCl) and were delivered from the laryngeal side of the epiglottis via a tracheal cannula. Responses were quantified as the number of impulses in 10 s minus the responses in the preceding 10 s of baseline activity during a rinse with physiological saline. 3. Distilled H2O, HCl, and NaCl were by far the most excitatory stimuli, with mean responses across all cells 5-10 times greater than those evoked by sucrose or QHCl. The order of effectiveness of the strongest concentrations of the stimuli was H2O greater than 0.03 M HCl greater than 1.0 M NaCl much greater than 0.03 M QHCl greater than 1.0 M sucrose. 4. The mean concentration-response function for NaCl was U shaped, with the greatest number of impulses to distilled H2O and 1.0 M NaCl. The responses diminished as the concentrations approached physiological levels (0.154 M NaCl), where there was no response, and increased as NaCl concentration rose above this level. Increasing concentrations of HCl above 0.0003 M elicited increasing responses in these fibers. 5. The mean time course of the responses to distilled H2O and to hypotonic NaCl solutions (0.01 and 0.03 M) peaked in the first few seconds and then declined slowly. This was distinct from the time course of the responses to hypertonic NaCl concentrations (0.3 and 1.0 M), which increased gradually throughout the 10-s response period. Responses to HCl peaked in the initial second and then decayed rapidly to a slowly declining plateau. These distinctively different time courses suggest different receptor mechanisms for water, salt, and acid stimuli. 6. The across-fiber pattern of the responses to hypotonic NaCl solutions correlated strongly to that elicited by distilled H2O.(ABSTRACT TRUNCATED AT 400 WORDS)  相似文献   
2.
The cerebellum receives information from many kinds of sensory organs (muscle, somatosensory, auditory, vestibular, visual) as well as from the autonomic system. The cerebellum presumably has a role in the control of tongue movement and salivary secretion. However, the relationship between cerebellar neuron activity and tongue sensation has not been investigated previously. In the present study, negative cerebellar field potentials in the molecular layer and single unit responses of Purkinje cells induced by electrical stimulation of the bullfrog glossopharyngeal (IXth) nerve or tongue surface were investigated. The interaction between IXth nerve stimulation and natural (taste and touch) stimulation of the tongue in their effects on cerebellar neuron activity were investigated. The negative field potentials were potentiated by a brief train of electrical pulses to the tongue or IXth nerve. With electrical stimulation of the tongue surface, several fungiform papillae were needed to elicit cerebellar field potentials. The latency of Purkinje cells following IXth nerve stimulation was 44.4-53.6 msec for complex spikes, whereas for simple spikes two maxima were seen, with mean values at 33.9-36 msec and 96.8 msec. A preceding electrical stimulation of the IXth nerve depressed the negative field potentials or Purkinje cell complex spike responses induced by test stimulation of the IXth nerve. These depressive effects were also seen following a preceding natural stimulation of the tongue and were dependent upon the type of preceding stimulation. The depressive effects were produced by preceding stimulation with NaCl, CaCl2, water, and touch, but not with quinine and acetic acid stimulation. These results clearly demonstrate that gustatory and tactile signals from the tongue can influence cerebellar neuron activity.  相似文献   
3.
Nitric oxide (NO) has recently been shown to modulate the hypothalamic–pituitary–adrenal axis response to interleukin-1β (IL-1β). We measured levels of nitrite (NO2) and nitrate (NO3) in the hypothalamic paraventricular nucleus (PVN) region using an in vivo brain microdialysis technique in conscious rats. Intraperitoneally administered IL-1β produced a significant increase in both NO2 and NO3 levels in the PVN region. We also examined the possible involvement of the abdominal vagal afferent nerves in this effect. In abdominal-vagotomized rats, the increase was significantly attenuated compared to that in sham-operated rats. Our results suggest that the abdominal vagal afferent nerves are involved in intraperitoneally administered IL-1β-induced NO release in the PVN region.  相似文献   
4.
Electrical stimulation through an acupuncture needle in a Chinese point of the human hand decreased the subjectively estimated sensation elicited by noxious and by tactile stimulation of the ipsilateral finger. A hyperbolic relationship was found between the stimulus duration (T, sec) required for the initiation of hypesthesia and the intensity of current (I, mA) passed through the acupuncture needle: I = 0.11 + 18/T.  相似文献   
5.
The responses of single neurons in the insular cortex to electrical stimulation of the chorda tympani (CT), lingual-tonsillar branch of the glossopharyngeal (LT-IXth) nerve, pharyngeal branch of the glossopharyngeal (PH-IXth) nerve, and superior laryngeal (SL) nerve were recorded in anaesthetized and paralyzed rats. Ninety-four neurons responding to stimulation of at least one of the four nerves were identified from the insular cortex. Most of the neurons were located in the posterior portion of the insular cortex; the mean location was 0.8 mm anterior to the anterior edge of the joining of the anterior commissure (AC) and was 1.4 mm dorsal to the rhinal fissure (RF). Of the 94 neurons, 84 (89%) received convergent inputs from two or more nerves, and the remaining 10 (11%) received inputs from one nerve. The neurons responding to the CT stimulation were distributed more anteriorly than those responding to other three nerves in the anterior-posterior dimension. Our results indicate that the neurons recorded mainly from the posterior portion of the insular cortex receive convergent inputs from the oropharyngolaryngeal regions.  相似文献   
6.
The bulbar potentials evoked by afferent volleys in the bullfrog glossopharyngeal nerve and in its 2 distal branches were studied. Following supramaximal electric stimulation of the peripheral nerve, the potential consisting of 2 triphasic deflections (S1 and S2) of presynaptic origin and 4 postsynaptic negative waves, N1, N2, N3 and N4, having the peak latency of 5, 8, 30 and 80 ms, respectively, was obtained along the nucleus fasciculus solitarius. By lowering the stimulus intensity to the threshold for exciting mechanosensitive fibers, only S1 followed by N1, N3 and N4 was produced, whereas, at higher intensities, S2 which accompanied by N2 became apparent. N1 and N2 waves were distributed over the bulbar dorsal surface with the maximal amplitude at 1-2 mm rostral to the obex and 0.5-1 mm lateral from the midline, the negativity being found maximal at the depth 0.5-1 mm from the surface. The surface-recorded N2 potential evoked by stimulation of the medial branch distributed caudal to that produced by stimulation of the lateral branch. Of intramedullary-recorded 4 negative waves, only N1 caused by volleys in the lateral branch distributed deeper layer than the one evoked by those in the other branch.  相似文献   
7.
The purpose of this study was to obtain detailed data on the dietary intake of energy, macronutrients, and micronutrients, especially minerals and vitamins, of healthy free-living people over the age of 70 in Japan and to clarify the correlations among nutrient intakes. The survey was conducted in November 2001 for 57 persons (men: 31, women: 26) aged 74 y (born in 1927) living in Niigata City, Japan. A precise weighing method was used to record food intake for three consecutive days. Nutrient intake was calculated based on the Standard Tables of Food Composition in Japan (5th ed.). The intakes of energy and total protein were 44.8+/-7.7 kcal/kg/d and 1.80+/-0.35 g/kg/d for men and 38.1+/-7.6 kcal/ kg/d and 1.51+/-0.26 g/kg/d for women. These values are significantly higher than those proposed by the current Recommended Dietary Allowances (RDAs) and the data by the 2001 National Nutrition Survey in Japan. The energy intake ratios from protein, carbohydrate and fat for men were 16 : 58 : 22, respectively, and the residual part was alcohol. For women, the ratios were 16 : 62 : 22. The proportion of total protein intake that consisted of animal protein was 57.8% for men and 52.8% for women. For both sexes, all of the mean daily intakes of nine minerals and 12 vitamins were higher than those prescribed for elderly Japanese people (> or =70 y) in the RDAs. Significant strong correlations were found between total protein intake and intakes of vitamins D, B2 and B6, as well as niacin and pantothenic acid (p<0.0001). Among the nine minerals, the correlations were very strong between potassium and magnesium, calcium and phosphorus, magnesium and iron, magnesium and copper, iron and copper, and zinc and copper (r's>0.700). For vitamins, strong correlations were found between vitamin A and folic acid, vitamin B2 and pantothenic acid, and folic acid and pantothenic acid. Furthermore, strong relationships were observed between potassium and folic acid, potassium and pantothenic acid, potassium and dietary fiber, phosphorus and vitamin B2, phosphorus and pantothenic acid, iron and folic acid, zinc and vitamin B12, and copper and vitamin B12. From these results, it is evident that age is not an important determinant of dietary intake among apparently healthy elderly Japanese people aged 74 y. In addition, the high intake of energy and protein in the Japanese dietary pattern, based upon high consumption of fish and/or shellfish, vegetables, and fruits, provide sufficient minerals and vitamins.  相似文献   
8.
The responses of 216 neurons in the nucleus tractus solitarius (NTS) of the American bullfrog were recorded following taste, temperature, and tactile stimulation. Cells were classified on the basis of their responses to 5 taste stimuli: 0.5 M NaCl, 0.0005 M quinine-HCl (QHCl), 0.01 M acetic acid, 0.5 M sucrose, and deionized water (water). Neurons showing excitatory responses to 1, 2, 3, or 4 of the 5 kinds of taste stimuli were named Type I, II, III, or IV, respectively. Cells whose spontaneous rate was inhibited by taste and/or tactile stimulation of the tongue were termed Type V. Type VI neurons were excited by tactile stimulation alone. Of the 216 cells, 115 were excited or inhibited by taste stimuli (Types I-V), with 35 being Type I, 34 Type II, 40 Type III, 2 Type IV and 4 Type V. The remaining 101 cells were responsive only to tactile stimulation (Type VI). Of those 111 cells excited by taste stimulation (Types I-IV), 106 (95%) responded to NaCl, 66 (59%) to acetic acid, 44 (40%) to QHCl, 10 (9%) to water, and 9 (8%) to warming. No cells responded to sucrose. Of the 111 cells of Types I-IV, 76 (68%) were also sensitive to mechanical stimulation of the tongue. There was some differential distribution of these neuron types within the NTS, with more narrowly tuned cells (Type I) being located more dorsally in the nucleus than the more broadly tuned (Type III) neurons. Cells responding exclusively to touch (Type VI) were also more dorsally situated than those responding to two or more taste stimuli (Types II and III).  相似文献   
9.
10.
We examined whether renal sympathetic nerve activity (RSNA) is suppressed in response to intracerebroventricular (i.c.v.) administration of hypertonic saline (HS) in conscious rats. RSNA was suppressed by i.c.v. administration of HS (0.3 M, 0.67 M, and 1.0 M, 1 microl/min for 20 min) in a concentration-dependent manner, which was attenuated under pentobarbital anesthesia. To elucidate mechanisms responsible for central HS-induced decrease in RSNA, possible involvement of arterial baroreceptors and peripheral arginine vasopressin (AVP) secreted from the posterior pituitary gland was examined using sinoaortic denervated (SAD) rats and non-peptide vasopressin receptor antagonists. The maximum suppression of RSNA (-81.5 +/- 5.5%) in control rats was significantly attenuated to -32.5 +/- 6.7% in SAD rats and to -55.8 +/- 5.7% in rats pretreated with intravenous vasopressin V1 receptor antagonist, OPC-21268 (5 mg/kg, i.v.). However, in SAD rats, pretreatment with vasopressin V1 receptor antagonist did not further affect the RSNA inhibition induced by central salt loading. The results suggest that the suppression of RSNA during central salt loading is mainly dependent on the arterial baroreceptors input and the 'additive' role of peripheral vasopressin.  相似文献   
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