全文获取类型
收费全文 | 474篇 |
免费 | 21篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 18篇 |
妇产科学 | 3篇 |
基础医学 | 49篇 |
口腔科学 | 4篇 |
临床医学 | 44篇 |
内科学 | 119篇 |
皮肤病学 | 5篇 |
神经病学 | 19篇 |
特种医学 | 108篇 |
外科学 | 37篇 |
综合类 | 13篇 |
预防医学 | 43篇 |
眼科学 | 12篇 |
药学 | 20篇 |
肿瘤学 | 14篇 |
出版年
2022年 | 5篇 |
2021年 | 3篇 |
2020年 | 13篇 |
2019年 | 9篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 13篇 |
2012年 | 9篇 |
2011年 | 8篇 |
2010年 | 19篇 |
2009年 | 16篇 |
2008年 | 6篇 |
2007年 | 19篇 |
2006年 | 12篇 |
2005年 | 12篇 |
2004年 | 14篇 |
2003年 | 15篇 |
2002年 | 9篇 |
2001年 | 14篇 |
2000年 | 13篇 |
1999年 | 19篇 |
1998年 | 23篇 |
1997年 | 18篇 |
1996年 | 27篇 |
1995年 | 14篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 14篇 |
1988年 | 23篇 |
1987年 | 11篇 |
1986年 | 9篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 3篇 |
1965年 | 3篇 |
1963年 | 2篇 |
1962年 | 2篇 |
1961年 | 2篇 |
排序方式: 共有511条查询结果,搜索用时 15 毫秒
1.
A new range of stand magnifiers has been released by the COIL company in the United Kingdom. Examination of these magnifiers reveals that they fail to deliver the rated magnifications labelled prominently on the appliances, as a result of the manufacturer's conformance with the requirements of the German DIN standard and the use of back vertex power (F'v) rather than equivalent dioptric power (Fm) of the magnifier. In this study we provide information on the optometric parameters of these new stand magnifiers that will assist the more accurate specification of improvements in vision expected from their use. 相似文献
2.
B. Shen MD Z. Younossi MD B. Dolmatch MD J. Newman MD M. Henderson MD J. Ong MD T. Gramlich MD M. Yamani MD 《The American journal of gastroenterology》2000,95(9):2607-2607
3.
Effect of pentylenetetrazol-induced convulsions on the development and expression of limbic kindled seizures 总被引:1,自引:0,他引:1
Male Long-Evans rats experienced three convulsions induced by intravenously administered pentylenetetrazol (PTZ) and were then kindled by electrical stimulation of the olfactory bulb or amygdala. Pretreatment with PTZ did not alter the rate of kindling in either site but did enhance the expression of kindled seizures once generalization had occurred (PTZ-treated animals had significantly longer motor seizures, measured by clonus duration, than did saline-treated controls). This suggests that PTZ-induced convulsions have selective effects on areas of the brain that are involved in the expression of the motor seizure. In addition, rats treated with PTZ after kindling had convulsions that were significantly longer in duration than any of their three pre-kindling convulsions, indicating that kindling produced an increased sensitivity to PTZ's convulsant effects. Comparison of this experiment with previous research suggests that the ability of a drug treatment to generate a kindling-like effect is related to the pattern of seizure activity that it produces. 相似文献
4.
Stephen Hunter Terry Gramlich Karen Abbott Vijay Varma 《Genes, chromosomes & cancer》1993,8(3):172-177
Carcinoma of the esophagus shows a strong male predominance and other epidemiologic differences from cancers arising at other sites. In this study, the prevalence of Y chromosome loss in 29 carcinomas of the esophagus and 53 carcinomas arising elsewhere in the aerodigestive tract was assessed by in situ hybridization of formalin-fixed paraffin-embedded tissue sections. Absence of the Y chromosome was defined as (1) negative staining for Y in neoplastic cells with positive staining for Y in immediately adjacent nonneoplastic epithelial and stromal cells, (2) positive staining of neoplastic cells with control probes for chromosomes X and 17, and (3) similar results at different stringencies and levels of protein digestion. According to these criteria, absence of the Y chromosome was observed in 13 of 14 (93%) adenocarcinomas of the esophagus, 8 of 13 (62%) squamous cell carcinomas of the esophagus, and 5 of 53 (9%) carcinomas arising in other sites. For the neoplasms examined, Y chromosome deletion was strongly and selectively associated with carcinomas, particularly adenocarcinomas, of the esophagus (P < .0001). These findings suggest that Y chromosome loss may be pathogenetically significant in these neoplasms. © 1993 Wiley-Liss, Inc. 相似文献
5.
Cytokeratin subsets can reliably distinguish Barrett's esophagus from intestinal metaplasia of the stomach 总被引:19,自引:0,他引:19
Ormsby AH Goldblum JR Rice TW Richter JE Falk GW Vaezi MF Gramlich TL 《Human pathology》1999,30(3):288-294
The histological distinction between intestinal metaplasia involving the distal esophagus (Barrett's esophagus [BE]) and intestinal metaplasia of the stomach has important clinical implications and can be difficult even with the use of histochemical mucin stains. Cytokeratin (CK) 7 and 20 are cytoplasmic structural proteins that show restricted expression in normal and malignant epithelia of the gastrointestinal tract. The aim of this study was to determine the use of CK7 and 20 expression in the histological distinction of BE from gastric intestinal metaplasia. CK7 and 20 immunostaining was performed on randomly selected surgical resection (n = 31) and biopsy specimens (n = 34) from patients with long-segment BE and gastric resection specimens (n = 11) and gastric cardia biopsy specimens (n = 13) in patients with histological evidence of intestinal metaplasia. A unique pattern of immunoreactivity designated the Barrett's CK7/20 pattern showed superficial CK20 staining and strong CK7 staining of both superficial and deep glands in 29 of 31 (94%) esophageal resection specimens and 34 of 34 (100%) esophageal biopsy specimens form patients with long-segment BE. A Barrett's CK7/20 pattern was not observed in gastric cardia biopsy specimens (n = 13) or gastric resection specimens (n = 11) in patients with histological evidence of intestinal metaplasia. The sensitivity, specificity, and positive predictive value of a Barrett's CK7/20 pattern for a diagnosis of long-segment BE was 97%, 100%, and 100%, respectively. CK7 and 20 reactivity patterns can reliably identify the location of intestinal metaplasia in the esophagus and stomach using histological material from both routine endoscopic biopsy and surgical resection specimens. 相似文献
6.
7.
Dane Christina Daoud MD Elena M. S. Cartagena MD MSc Katherine J. P. Schwenger RD PhD Nicha Somlaw MD Leah Gramlich MD Scott Whittaker MD David Armstrong MD Brian Jurewitsch PharmD Matreyi Raman MD Donald R. Duerksen MD James D. McHattie MD Johane P. Allard MD 《JPEN. Journal of parenteral and enteral nutrition》2022,46(2):348-356
8.
9.
Abstract: We report the first case of fatal anthrax meningoencephalitis in Hong Kong over the past 60 years. A 13 year-old boy presented with right lower quadrant pain, diarrhoea and progressive headache. Lumbar puncture yielded gram positive bacilli initially thought to be Bacillus cereus, a contaminant. He was treated with ampicillin and cefotaxime, but died 3 days after hospitalization. The organism isolated from blood and cerebrospinal fluid was later identified as Bacillus anthracis. 相似文献
10.
Gonzales AJ; Christensen JG; Preston RJ; Goldsworthy TL; Tlsty TD; Fox TR 《Carcinogenesis》1998,19(7):1173-1183