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排序方式: 共有160条查询结果,搜索用时 15 毫秒
1.
S Gunasti† SS Marakli† I Tuncer‡ N Ozpoyraz§ VL Aksungur† 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):811-817
BACKGROUND: We have seen several patients with itchy lichenified plaques located bilaterally on the elbows and/or knees and have named this condition 'psoriatic neurodermatitis' (PN). OBJECTIVE: The purpose of this study was to compare clinical and histopathological characteristics of these patients to those of patients with typical lichen simplex chronicus (LSC). METHODS: Nineteen patients with PN and 34 patients with typical LSC were included. Besides clinical dermatological evaluation, the prick test was carried out on 49 patients; the Phadiatop test on 40 patients; the patch test with European standard series on 47 patients; histopathological evaluation on 39 patients; and clinical psychiatric examination on 38 patients. RESULTS: Almost exclusively, PN was seen in females and was located on the extremities. It caused more plaques than typical LSC did. In PN, the plaques were smaller, sharper, more keratotic and less excoriated, and had fewer lichenoid papules around them. Itching was usually more severe in the evening, while resting and in a hot environment in typical LSC, but not in PN. In plaques of PN, microabscesses in the horny layer, hypogranulosis, regular acanthosis and thinning of the suprapapillary plates were more frequent, and hyperpigmentation in the basal layer was less. In patients with PN, depressive disorder was found more frequently; and generalized anxiety disorder or psychosomatic characteristics, less. There were no significant differences in the results of prick, Phadiatop and patch tests between patients with PN and those with typical LSC. CONCLUSION: In our opinion, it is most likely that the so-called PN is itchy psoriasis superimposed by LSC. 相似文献
2.
V. L. Gracco J. H. Abbs 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1986,65(1):156-166
Summary Upper lip, lower lip, and jaw kinematics during select speech behaviors were studied in an attempt to identify potential invariant characteristics associated with this highly skilled motor behavior. Data indicated that speech motor actions are executed and planned presumably in terms of relatively invariant combined multimovement gestures. In contrast, the individual upper lip, lower lip, and jaw movements and their moment-to-moment coordination were executed in a variable manner, demonstrating substantial motor equivalence. Based on the trial-to-trial variability in the movement amplitudes, absolute positions, and velocities of the upper lip, lower lip, and jaw, it appears that speech motor planning is not formulated in terms of spatial coordinates. Seemingly, object-level planning for speech may be encoded in relation to the acoustic consequences of the movements and ultimately with regard to listener's auditory perceptions. In addition, certain temporal parameters among the three movements (relative times of movement onsets and velocity peaks) were related stereotypically, reflecting invariances characteristic of more automatic motor behaviors such as chewing and locomotion. These data thus appear to provide some additional insights into the hierarchy of multimovement control. At the top of the motor control hierarchy, the overall plan appears to be generated with explicit specification of certain temporal parameters. Subsequently, based upon the plan and within that stereotypic temporal framework, covariable adjustments among the individual movements are implemented. Given the results of previous perturbation studies, it is hypothesized that these covariable velocity and amplitude adjustments reflect the action of sensorimptor mechanisms. 相似文献
3.
V. L. Gracco J. H. Abbs 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1988,71(3):515-526
Summary Previous speech kinematic studies have demonstrated systematic timing relations among the upper lip, lower lip, and jaw suggesting the operation of a central pattern generator (CPG). The present study evaluated the consistency of these timing relations following unanticipated perturbation of the lower lip. Using this approach, it was also possible to evaluate the influence of sensory information on the timing of motor output and subsequent coordination of the multiple speech movements. Perturbations were applied to the lower lip during the closing movement associated with the first p in sapapple. Muscle activity and movements of the upper lip, lower lip, and jaw were obtained. Changes in movement displacement, velocity and duration, the timing and sequencing of peak velocities, EMG area, and EMG rise time were analyzed for the control and load conditions. Similar to previous perturbation results, significant magnitude compensations from the muscles and movements of the upper lip, lower lip, and jaw were observed. In contrast, movement durations and the sequencing of peak velocities were relatively unaffected by the lower lip load. The timing of peak EMG amplitude and consequently the timing of peak closing velocity for all structures (UL, LL, and J) occurred earlier relative to the preceding opening movement. These results are consistent with the interaction of phasic sensory input with centrally-driven commands resulting in a phase-advanced motor output. Further, as the timing of one structure is modified so were all the functionally-linked components thereby maintaining the necessary coordination. As in other rhythmic motor behaviors such as locomotion and chewing, there appears to be a centrally patterned framework for speech movement coordination. 相似文献
4.
5.
R Francavilla VL Miniello L Brunetti ME Lionetti L Armenio 《Acta paediatrica (Oslo, Norway : 1992)》2003,92(S441):101-104
A major complication of cholestasis is fat malabsorption related to decreased intestinal bile acids, which leads to malnutrition and fat-soluble vitamin deficiency. The impaired excretion of bile acids leads to a low intraluminal micellar concentration that causes long-chain triglyceride lipolysis and absorption to be ineffective. Medium-chain triglycerides (MCTs) are more readily absorbed when there are low concentrations of bile acids and therefore are a good source of fat calories; MCTs can be administered as MCT-containing formulas. In those children who are unable to take sufficient calories by mouth, it is important to start nocturnal enteral feeding to improve nutritional status. In infants with cholestasis, the absorption of fat-soluble vitamins (A, D, E and K) that require bile acids is also impaired, and supplementation is mandatory. Vitamin K deficiency may be responsible for hypoprothrombinaemia, which may lead to bleeding diathesis, Vitamin K (phytomenadione) should therefore be promptly administered intravenously, at a dose of 1 mg. Chronic vitamin E (α-tocopherol) deficiency is associated with a progressive neuromuscular syndrome that can cause cerebellar ataxia, areflexia and peripheral neuropathy. Supplements are given orally in doses of 3–5 times the normal requirement if cholestasis is incomplete. In complete cholestasis, supplements must be given intramuscularly at monthly intervals. In infants who fail to thrive, dietary supplements of carbohydrate polymers and MCTs are required. 相似文献
6.
Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP 总被引:21,自引:3,他引:21
Chronic idiopathic thrombocytopenic purpura (ITP) is caused by an antibody reactive with platelet-associated antigens. The present studies provide direct evidence that some patients with chronic ITP have autoantibodies against the platelet glycoprotein (GP) IIb/IIIa complex. Microtiter wells, coated with a monoclonal antibody (2G12) specific for GPIIb/GPIIIa were reacted with GPIIb/GPIIIa contained in a platelet extract. Control wells containing the same antibody were reacted with a cell extract containing no GPIIb/GPIIIa. After washing, the wells were reacted with patient or control plasma, and IgG binding was detected using 125I-Fab2-anti-human IgG. Assay values were expressed as binding ratios (cpm GPIIb/GPIIIa wells/cpm control wells). Plasma from 5 of 56 patients with chronic ITP had ratios (1.36-3.14) greater than 3 standard deviations above the mean (+/- SD) of control plasmas--0.93 +/- 0.12. Elevated values were also noted in two patients with anti-P1A1 antibody (ratios greater than 30) and in one patient with Hodgkin's disease and an ITP-like syndrome (ratio 1.53). Normal values were noted in 34 patients with a variety of immune and nonimmune diseases. Plasma from two of the positive ITP patients was reacted with 125I-surface-labeled platelets and, after solubilization, the IgG and bound antigen were precipitated with Staph-A. Autoradiographs from SDS- PAGE electrophoresis of the Staph-A-bound proteins shows two radioactive bands consistent in size with GPIIb and GPIIIa. 相似文献
7.
Ng VL; Hurt MH; Fein CL; Khayam-Bashi F; Marsh J; Nunes WM; McPhaul LW; Feigal E; Nelson P; Herndier BG 《Blood》1994,83(4):1067-1078
Two B-cell lines, 2F7 and 10C9, were established by single cell cloning from biopsies obtained from two acquired immune deficiency syndrome patients with Burkitt's lymphoma. Representation of the original tumors was verified by demonstration of (1) identical biallelic rearrangement of Ig genes for 2F7 and (2) shared idiotype for 10C9. Both cell lines displayed cell-surface Ig and secreted Ig (IgM lambda for 2F7, IgM kappa for 10C9). IgMs from both cell lines immunoprecipitated actin; in addition, 2F7 IgM lambda immunoprecipitated recombinant human immunodeficiency virus type 1 (HIV-1) gp 160. 2F7 IgM lambda did not react with other autoantigens (double-stranded and single-stranded DNA, actin, bovine serum albumin, IgG), whereas 10C9 IgM kappa reacted with human IgG. The 2F7 IgM heavy-chain variable region (VH) showed a 95% nucleotide homology with a previously sequenced VHIII germline gene, hv3019b9, whereas the 10C9 IgM VH showed a 95% homology with a previously sequenced VHIV germline gene, VH4.21. Use of minimally modified VH genes and demonstration of reactivity with chronically present antigens (ie, actin, HIV-1 gp 160, or human IgG) suggests that B cells in HIV-1-infected individuals proliferating in response to chronic antigenic stimulation may be at increased risk for lymphomagenesis. 相似文献
8.
In this study we evaluated different radiographic exams for the localization of impacted maxillary canines (orthopantomography (OPT), laterolateral and posteroanterior teleradiography, parallax method, laterolateral, occlusal radiography, computerized axial tomography, cone beam CT) highlighting the advantages and disadvantages of each. Four patients with impacted maxillary canines underwent selected radiographic investigations which allowed us to discuss their potential in identifying the position relative to the impacted teeth in the upper jaw. It was not possible to carry out all methods on the same patient as the level of radiation exposure experienced by each patient would too high and therefore unethical. Each method revealed the position of the canine with respect to the adjacent structures and the inclination of the major axis of the impacted tooth with respect to the plane of reference. We then evaluated the ease of use, the dosage of radiation emitted, the significance of the localization of the impacted canine, the immediacy of availability of the information required and the cost of each method. Each technique presented intrinsic advantages and limitations; however CBCT provides elements which escape during traditional radiographic analysis and is therefore indicated in case of impacted teeth or cranio-facial structural anomalies. 相似文献
9.
Using flow cytometry and osmotic lysis measurements, we document here the means and coefficients of variation of the following red cell (RBC) properties: hemoglobin (Hb) content, volume, Hb concentration, and relative lytic tonicity distributions in populations of normal human RBCs, before and after density fractionation. The distributions showed a pattern characterized by much larger coefficients of variation of the Hb content and volume distributions than of the Hb concentration and relative lytic tonicity distributions. From analysis of the factors that determine those RBC properties, the patterns were interpreted as reflecting previously unrecognized statistical proportionalities between cell osmolyte content, Hb content, and membrane area. The possible origin of these statistical links was analyzed by considering alternative models with and without the participation of regulatory processes during cell maturation. A model was shown to be feasible in which mature RBC variability with proportional volume, area, and Hb content arises solely from cell size variability at the last erythroid cell division. 相似文献
10.
CAllyson Jones Sheri L Pohar Sharon Warren Karen VL Turpin Kenneth G Warren 《Health and quality of life outcomes》2008,6(1):1