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Joachim Dissemond Andreas Krber Stephan Grabbe 《Journal der Deutschen Dermatologischen Gesellschaft》2006,4(8):627-634
In Germany about 0.7 % of the adult population have a chronic leg ulcer. Although chronic venous insufficiency accounts for at least 80 % of all chronic leg ulcers, knowledge of the relevant differential diagnostic considerations is of crucial importance, in particular for patients who are refractory to therapy. In addition to vascular disease, other causes include neuropathic, metabolic, hematologic and exogenous factors as well as neoplasias, infections, drugs, genetic defects and some primary skin disorders. For the long‐term successful treatment of patients with chronic leg ulcers, it is necessary to identify all relevant factors, in order to enable a pathogenesis‐oriented, interdisciplinary therapeutic approach. 相似文献
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Inflammation Research - 相似文献
6.
Silvia Obenauer Christian Sohns Carola Werner Eckhardt Grabbe 《Journal of digital imaging》2006,19(3):258-263
The goal of this study was to evaluate the performance of a computer-aided detection (CAD) system in full-field digital mammography
(Senographe 2000D, General Electric, Buc, France) in finding out carcinomas depending on the parenchymal density. A total
of 226 mediolateral oblique (MLO) and 186 craniocaudal (CC) mammographic views of histologically proven cancers were retrospectively
evaluated with a digital CAD system (ImageChecker V2.3 R2 Technology, Los Altos, CA, USA). Malignant tumors were detected
correctly by CAD in MLO view in 84.85% in breasts with parenchymal tissue density of the American College of Radiology (ACR)
type 1, in 70.33% of the ACR type 2, in 68.12% of the ACR type 3, and in 69.70% of the ACR type 4. For the CC view, similar
results were found according to the ACR types. Using the chi-square and McNemar tests, there was no statistical significance.
However, a trend of better detection could be seen with decreasing ACR type. In conclusion, there seems to be a tendency for
breast tissue density to affect the detection rate of breast cancer when using the CAD system. 相似文献
7.
Acute diseases of the central arteries require an immediate investigation. An efficient, fast and reliable diagnosis is necessary because of the high mortality, if the patient remains untreated. These requirements are perfectly fulfilled by the new CT-techniques. METHODS: Suspected aortic diseases were examined with a new multi-slice helical CT. The thoracic or the abdominal aorta as well as the entire vascular tree from the supra-aortic branches to the inguinal arteries were investigated with different CT protocols. The slice-thickness and the scan mode were changed while the total examination time was kept constant for the first two groups. In the third group a monophasic examination was compared to a biphasic one. RESULTS: In the diagnosis of acute aortic diseases multi-slice helical CT proved to be a fast and reliable method with all scan protocols. The objective measurements of contrast homogeneity and image quality were comparable in the first two groups. The monophasic contrast medium injection protocol was superior to the biphasic administration mode. CONCLUSIONS: Multi-slice helical CT appears to be a very effective approach for the diagnosis of acute aortic diseases and seems to be the new gold standard. 相似文献
8.
A phantom consisting of four components was developed to simulate contrast-enhanced MR imaging of the breast. These components
included the correlation between the signal intensity and the contrast medium concentration, the uniformity of signals within
surface coils, artefacts due to opposed-phase imaging effects, spatial resolution and the acquisition of relevant signal-to-time
curves. Repetitive measurements demonstrated an excellent reproduction of phantom imaging with a deviation in signal intensity
of approximately 5 %. The presented phantom allows the optimization of examination protocols as well as the comparison of
different examination techniques. Furthermore, it enables the routine quality monitoring of contrast-enhanced MR imaging of
the breast.
Received: 28 May 1998; Revised: 3 September 1998; Accepted: 14 October 1998 相似文献
9.
Soenke H Bartling Rajiv Gupta Attila Torkos Christian Dullin Grabbe Eckhardt Thomas Lenarz Hartmut Becker Timo St?ver 《Otology & neurotology》2006,27(4):491-498
HYPOTHESIS: Flat-panel based volume computed tomography could improve cochlear implant electrode evaluation in comparison with multislice computed tomography. BACKGROUND: Flat-panel based volume computed tomography offers higher spatial resolution and less metal artifacts than multislice computed tomography. Both characteristics could improve the evaluation of challenging but important questions in cochlear implantation assessment, such as an exact imaging of cochlea, osseous spiral lamina, electrode array position, and single electrode contacts. These questions are not currently fully answered by multislice computed tomography. METHODS: Four isolated temporal bone specimens were scanned in a current multislice computed tomography scanner and in two experimental flat-panel based volume computed tomography scanners before and after cochlea implantation. To compare flat-panel based volume computed tomography and multislice computed tomography, four features were rated according to the following criteria: 1) visibility of the cochlea; 2) visibility of the osseous spiral lamina; 3) discernibility of individual electrode contacts; and 4) the ability to determine the electrode array position relative to scala tympani and scala vestibuli. Layer-by-layer microgrinding pictures were used as the ground truth for verification of imaging findings. RESULTS: Flat-panel based volume computed tomography was superior to multislice computed tomography in all four features rated. The cochlea and facial nerve canal were much better delineated in flat-panel based volume computed tomography. The osseous spiral lamina and single electrode contacts were only visible in flat-panel based volume computed tomography. Assessment of implant position with regard to the cochlear spaces was considerably improved by flat-panel based volume computed tomography. CONCLUSION: Cochlear implantation assessment could be improved by flat-panel based volume computed tomography and, therefore, would be highly beneficial for cochlea implantation research and for clinical evaluation. However, these first results were shown by scanning isolated temporal bone specimens; scanning whole human skull bases might be more challenging. 相似文献
10.
I. Heide A. C. Sokoll B. M. Henz S. Nagel K. Kreißig A. Grützkau J. Grabbe B. Wittig A. Neubauer 《Annals of hematology》1998,77(5):199-206
The receptor tyrosine kinase Axl which expresses extracellular domains reminiscent of cell adhesion molecules, is involved in homotypic binding as well as
in intracellular signaling of myeloid progenitor cells. In order to investigate factors which might influence differentiation
pathways through changes of the adhesive properties of cells, we analyzed the expression of axl in immature basophil and mast cell lines and in cultured basophil and mast cell precursors. Axl expression was induced by interferon-α in the human leukemic mast cell line HMC-1 and in cultured mast cells derived from
CD34+ peripheral blood cells. Axl induction was dose dependent, appeared within 1 h, and was independent of de novo protein synthesis. IFNα-treated HMC-1 cells
expressing axl formed large cell aggregates within 40 h while untreated cells did not. HMC-1 cells also expressed gas6, the putative ligand of axl, which has been shown to induce axl–mediated homotypic binding. Gas6 expression was independent of interferon treatment in HMC-1 cells. The present results suggest that axl–mediated changes of cellular adhesive properties in mast cells may be important in mast cell differentiation as well as in
mast cell-associated inflammation.
Received: May 27, 1998 / Accepted: July 4, 1998 相似文献