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AR Jones BSC AJP Sandison FRCS WJ Owen MS FRCS 《International journal of clinical practice》1997,51(5):294-295
Pre-clerking of all patients undergoing elective general surgical operations was introduced at our hospital in an attempt to reduce an unacceptably high operation cancellation rate. A prospective audit has been performed on the effect of this policy on the cancellation rate. Before the introduction of pre-clerking there was a marked seasonal variation in the number of patients who failed to attend for surgery, which could be explained by absence on holiday. This seasonal variation disappeared after the start of pre-clerking clinics, but there has been no reduction in the number of cancellations for medical reasons. 相似文献
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P A Giblin D J Leahy J Mennone P B Kavathas 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(5):1716-1720
The CD8 dimer interacts with the alpha 3 domain of
major histocompatibility complex class I molecules through two immunoglobulin
variable-like domains. In this study a crystal structure-informed mutational
analysis has been performed to identify amino acids in the CD8 alpha/alpha
homodimer that are likely to be involved in binding to class I. Several key
residues are situated on the top face of the dimer within loops analogous to the
complementarity-determining regions (CDRs) of immunoglobulin. In addition, other
important amino acids are located in the A and B beta-strands on the sides of
the dimer. The potential involvement of amino acids on both the top and the side
faces of the molecule is consistent with a bivalent model for the interaction
between a single CD8 alpha/alpha homodimer and two class I molecules and may
have important implications for signal transduction in class I-expressing cells.
This study also demonstrates a role for the positive surface potential of CD8 in
class I binding and complements previous work demonstrating the importance of a
negatively charged loop on the alpha 3 domain of class I for CD8
alpha/alpha-class I interaction. We propose a model whereby residues located on
the CDR-like loops of the CD8 homodimer interact with the alpha 3 domain of MHC
class I while amino acids on the side of the molecule containing the A and B
beta-strands contact the alpha 2 domain of class I. 相似文献
6.
Berbaum KS; el-Khoury GY; Franken EA Jr; Kathol M; Montgomery WJ; Hesson W 《Radiology》1988,168(2):507-511
The effect of knowledge of localizing symptoms and signs in the detection of fractures was studied. Forty radiographs of the extremities were examined twice by seven radiologists; the sessions were separated by 4 months. In 26 cases, a subtle fracture was present; 14 cases were normal. In half of the cases at each session, the precise location of pain, tenderness, or swelling was provided. The observer was asked to determine if the case was normal or abnormal (provide the exact location of the fracture) and to indicate the degree of confidence in the diagnosis. Responses were converted to a numeric scale for analysis. Analysis of receiver operator characteristic parameters indicates that clues regarding location of trauma facilitate detection of fractures. The improvement is based largely on an increased true-positive rate without an increased false-positive rate, regardless of the decision criteria of the radiologist (overall willingness to "overread" or "underread"). This has direct clinical applicability and reinforces the plea of radiologists for precise clinical information. 相似文献
7.
Lei Wan, Poliporus mylittae Cook et Mass(Omphalia lapidescena Scbraet) is a kind of fungus used in traditional Chinese medicine, as an antheiminthie From Lei Wan, an "active component designated as. S-4001 had been isolated.Preliminary results indicate that S-4001 belongs to D, β, 1-3 glucan with some 1-6 linkages.After administration of S-4001, significant antiinflammatory activity was found in various experimental animal models, including croton oil induced ear edema in mice and agar or yeast induced ankle swelling in rats. An inhibitory action on leucocyte migration inducced by intraperitoneal injection of CMC in rats was also observed. The plasma content of corticosterone was significantly increased, but the content of ascorbic acid in the adrenals did not change in rats given S-4001. Apart from these actions, S-4001 showed a number of immunostimulating actions such as increasing the clearance of Congo red from mice blood and potentiating the immunohemolysis reaction in 615 mice. 相似文献
8.
Background
There is currently an unprecedented expressed need and demand for estimates of maternal mortality in developing countries. This has been stimulated in part by the creation of a Millennium Development Goal that will be judged partly on the basis of reductions in maternal mortality by 2015. 相似文献9.
Lactate production in isolated perfused rat lung 总被引:1,自引:0,他引:1
10.
Sleep patterns and stability in perimenopausal women 总被引:2,自引:1,他引:2
Women between the ages of 40 and 59 years were classified as pre-, peri-, and postmenopausal, with and without hot flash symptoms, for comparison of somnographic sleep variables. Few differences in sleep variables were noted between the groups. However, peri- and postmenopausal women experiencing hot flashes (symptomatic) tended to have lower sleep efficiencies than those not experiencing hot flashes. As well, rapid-eye-movement (REM) latency was longer (p less than 0.05) in the symptomatic women (means = 94.2 min) than in the nonsymptomatic women (means = 71.4 min). Although an age difference existed between the menopausal status groups, it was less than a decade and a main group effect for sleep efficiency and REM latency was seen while controlling for age and/or depression. 相似文献