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妊娠晚期人类小DNA病毒B19感染情况,母婴传播及与早产或小于胎龄儿关系的研究 总被引:2,自引:0,他引:2
为了解妊娠晚期人类小DNA病毒B19(HPVB19)感染情况、母婴传播及与早产或小于胎龄儿的关系,将104例母亲及其新生儿分成两组,试验组包括19例早产儿、32例小于胎龄儿及其母亲;对照组包括53例正常新生儿及其母亲。采用聚合酶链反应技术(PCR)检测母血、脐血和胎盘组织HPVB19DNA;用鼠抗B19单克隆抗体和B19联合抗原(VP1+VP2)建立了捕获式ELISA法检测母血和脐血HPVB19特异性IgM抗体。结果:104例母血中,HPVB19IgM阳性2例(1.9%),104例脐血中阳性3例(2.9%)。在母血、脐血及胎盘组织各104例中检出HPVB19DNA阳性分别为6例、4例、6例。因此试验组51对母婴共102例中6例有HPVB19感染(5.9%);对照组53对母婴共106例中2例有HPVB19感染(1.9%)。两组B19感染率差异无显著意义。提示:在北京地区,妊娠晚期存在B19急性感染,应引起重视;B19感染与早产或小于胎龄儿的发生可能不相关;新生儿B19感染是通过胎盘传播的。对有B19感染证据的新生儿进行随访及研究如何阻止胎盘传播很重要。 相似文献
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Kretzing S Abraham G Seiwert B Ungemach FR Krügel U Teichert J Regenthal R 《Archives of toxicology》2011,85(12):1565-1573
Lycorine is the main alkaloid of many Amaryllidaceae and known to cause poisoning with still unknown mechanisms. Longer lasting
toxicological core symptoms of nausea and emesis may become a burden for human and animal patients and may result in substantial
loss of water and electrolytes. To optimise the only empirical symptomatic antiemetic drug treatment at present, it is important
to elucidate the causative involved targets of lycorine-induced emesis. Therefore, in the current study, we have tested the
actions of a various antiemetic drugs with selective receptor affinities on lycorine-induced nausea and emesis in vivo in
dogs. Beagle dogs were pre-treated in a saline vehicle-controlled crossover and random design with diphenhydramine, maropitant,
metoclopramide, ondansetron or scopolamine prior lycorine administration (2 mg/kg subcutaneously). In vivo effects were assessed
by a scoring system for nausea and emesis as well as by the number and lag time of emetic events for at least 3 h. Moreover,
plasma pharmacokinetic analysis was carried out for ondansetron before and after lycorine injection. The data show that histaminergic
(H1), muscarinic and dopaminergic (D2) receptors are presumably not involved in lycorine-induced emetic effects. While ondansetron significantly reduced the number
of emetic events, lycorine-induced emesis was completely blocked by maropitant. Only ondansetron also significantly decreased
the level of nausea and was able to prolong the lag time until onset of emesis suggesting a preferential participation of
5-HT3 receptors in lycorine-induced nausea. Thus, it is the first in vivo report evidencing that predominantly neurokinin-1 (NK1) and to a lesser extent 5-hydroxytryptamine 3 (5-HT3) receptors are involved in lycorine-induced emesis facilitating a target-oriented therapy. 相似文献
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Examining Perceptions of Rapid Population Growth in North and South Gondar Zones, Northwest Ethiopia
Ethiopia is one of the most populous countries in Africa and ranks second only to Nigeria. Rapid population growth has hampered the country''s development, making the eradication of extreme poverty and hunger difficult. This study which had two components—quantitative and qualitative—was aimed at exploring the perceptions of women and other social groups on the prevailing population pressures. The quantitative study involved 3,512 women aged 15–49 years. The qualitative study consisted of five focus-group discussions and six key-informant interviews. Over 90% of women (n=3,512) who participated in the quantitative study and nearly all the focus-group discussants and interviewees (n=39) felt that something should be done to keep the population from growing too fast. Most (over 90%) participants approved of the Government passing a law regarding the maximum number of children that a couple should have. It is, therefore, timely for the responsible bodies to exert maximum effort and commitment in responding to the emerging attitudes of the people by making the population problem a priority.Key words: Cross-sectional studies, Perceptions, Population growth, Ethiopia 相似文献
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We examined the inhibitory sympathetic beta-adrenergic mechanisms in peripheral lung, bronchi and trachea of an equine model of recurrent airway obstruction (RAO), to support the hypothesis that the beta-adrenergic receptor dysfunction is not only restricted to cell surface receptor density but rather encompasses a mechanistic defect apart from the receptor, to the intracellular signaling components. The non-asthmatic lung possessed 3.2-fold more beta-adrenergic receptors than bronchi (496 +/- 19.4 vs. 155.1+/- 19.6 fmol/mg protein; P < 0.01) and 6.2-fold higher than in the trachea (79.8 +/- 12.6 fmol/mg protein; P < 0.001) (assessed by radioligand binding assays using (-)-[(125)I]-iodocyanopindolol, ICYP) and in all tissues a greater proportion of the beta(2)- than the beta(1)-subtype (75-80%). The receptor density (B(max)) in lung parenchyma and bronchial membranes was 33 and 42%, respectively, lower (P < 0.001) in RAO than in control animals, attributable to a decrease in the beta(2)-subtype. This receptor down-regulation was accompanied with an attenuated coupling efficiency of the receptor to the stimulatory G(S)-protein (P < 0.05 vs. control). Concomitantly, activation of adenylate cyclase evoked by isoproterenol was significantly reduced in lung and bronchial membranes of animals with RAO, whereas effects of 10 microM GTP, 10mM NaF, 10 microM forskolin and 10 mM Mn(2+) were not altered. There was no difference in beta-adrenergic receptor density, G(S)-protein or adenylate cyclase coupling in the trachea between asthmatic and control animals. In conclusion, in stable asthma the pulmonary beta-adrenergic receptor-G(S)-protein-adenylate cyclase system is impaired, thus the pathologic process involves all signaling components, and due to its close similarity, this animal model seems to serve as a suitable model, at least partly, of chronic asthmatic patients. 相似文献
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The effects of single injections of glucocorticoid (GC) depot suspension and of long-acting GC were studied in conscious dogs. Both the depot suspension GC triamcinolone-16,17-alpha-acetonide (TAA) and the long-acting triamcinolone acetonide-21-dihydrogen phosphate (TAA-DHP) decreased basal and ACTH-stimulated cortisol levels and in a specific time-dependent way. Before treatment, all dogs had normal basal and peak cortisol responses to ACTH challenge (13-15 and > 120 nmol/l at 1 h respectively). Intravenous TAA-DHP reduced cortisol levels for 12 h, i.m. TAA reduced cortisol levels as of 1.5 h and the effect lasted for at least 4 weeks. Both treatments blunted the peak response to ACTH. ACTH elevated cortisol levels to or above baseline values within 10 days following TAA-DHP treatment, but the TAA treatment suppressed an ACTH response for at least 4 weeks. Kinetic analysis of both the preparations demonstrated rapid absorption (tmax, 0.6-1.5 h) and low maximum plasma concentrations (peak Cmax, 2.99-5.51 nmol/l) of the steroids; indeed, the terminal half-life of TAA-DHP (13.9 +/- 1.3 h) was very much shorter than that of TAA (125.9 +/- 15.8 h). In addition, the mean residence time differed very much (11 vs 160 h for TAA-DHP and TAA respectively), in line with a delayed elimination of the depot compared with the long-acting formulation. Application of these TAA formulations needs careful evaluation for their surprisingly different effects on endocrine stress axis activity. 相似文献
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