全文获取类型
收费全文 | 3252篇 |
免费 | 409篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 142篇 |
妇产科学 | 302篇 |
基础医学 | 329篇 |
口腔科学 | 66篇 |
临床医学 | 981篇 |
内科学 | 454篇 |
皮肤病学 | 79篇 |
神经病学 | 121篇 |
特种医学 | 278篇 |
外科学 | 335篇 |
综合类 | 58篇 |
预防医学 | 138篇 |
眼科学 | 8篇 |
药学 | 194篇 |
肿瘤学 | 174篇 |
出版年
2023年 | 50篇 |
2021年 | 32篇 |
2020年 | 49篇 |
2019年 | 44篇 |
2018年 | 92篇 |
2017年 | 107篇 |
2016年 | 108篇 |
2015年 | 123篇 |
2014年 | 130篇 |
2013年 | 144篇 |
2012年 | 101篇 |
2011年 | 120篇 |
2010年 | 138篇 |
2009年 | 142篇 |
2008年 | 111篇 |
2007年 | 124篇 |
2006年 | 98篇 |
2005年 | 102篇 |
2004年 | 85篇 |
2003年 | 103篇 |
2002年 | 82篇 |
2001年 | 87篇 |
2000年 | 60篇 |
1999年 | 99篇 |
1998年 | 119篇 |
1997年 | 128篇 |
1996年 | 124篇 |
1995年 | 108篇 |
1994年 | 69篇 |
1993年 | 61篇 |
1992年 | 47篇 |
1991年 | 47篇 |
1990年 | 34篇 |
1989年 | 63篇 |
1988年 | 53篇 |
1987年 | 35篇 |
1986年 | 45篇 |
1985年 | 52篇 |
1984年 | 33篇 |
1983年 | 29篇 |
1982年 | 30篇 |
1981年 | 19篇 |
1980年 | 25篇 |
1979年 | 26篇 |
1978年 | 29篇 |
1977年 | 23篇 |
1976年 | 16篇 |
1975年 | 16篇 |
1967年 | 15篇 |
1966年 | 15篇 |
排序方式: 共有3673条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
D Van Neste† RM Trüeb‡ 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):578-583
BACKGROUND: Computer-assisted image analysis has been proposed for human hair growth studies. METHODS: The performances of Trichoscan, a commercially available automated system combining epiluminiscence microscopy with digital image analysis, developed for office-based hair growth measurements, have been evaluated comparatively on the same skin sites using standardized photographic equipment and calibrated processing for contrast-enhanced phototrichogram (CE-PTG) analysis. This reference method has been validated with scalp biopsies and histological examination of serial sectioning. RESULTS: Besides edge effects, hair fibres escaped the Trichoscan analysis for various reasons including, but not limited to, thickness, pigmentation, closeness and crossing. CONCLUSION: Most of these problems have been identified in the late 1980s and remain largely unsolved by the processing software that was evaluated in 2004. Therefore claims promoting the Trichoscan method for accurate hair measurements in clinical trials on scalp and body hair are not supported by the present investigation. The speed at which the analysis is performed is outweighed by the errors in signal detection. Therefore we suggest that improvements must be clearly documented before Trichoscan is established for quantified diagnostic purposes and detailed hair cycle monitoring during hair trials. 相似文献
5.
6.
7.
Stefano Elia Gianluca Guggino Davide Mineo Gianluca Vanni Antonello Gatti Tommaso Claudio Mineo 《European journal of cardio-thoracic surgery》2005,28(2):312-7; discussion 317
OBJECTIVE: To verify the feasibility and compare the results of thoracoscopic sympathectomy under local anaesthesia (LA) and spontaneous breathing vs. general anaesthesia (GA) with one-lung ventilation. METHODS: Two groups of consecutive patients underwent one stage bilateral T2-T3 thoracoscopic sympathectomy under LA (n=15) and GA (n=30) by the same surgical team for treatment of primary palmar hyperhidrosis. The groups were homogeneous for relevant demographic, physiological and clinical data, including pulmonary function. In both groups, patient's satisfaction was evaluated 24h after surgery by a simple interview and scored into five grades (1=very poor to 5=excellent), while quality of life (QOL) was evaluated by SF-36 and Nottingham's Health Profile questionnaires before and 6 months after surgery. A cost comparison between groups concerning devices, drugs, global in operating room time, medical personnel and hospital stay was also carried out. RESULTS: No operative mortality was recorded. The overall in operating room time for the whole bilateral procedure under LA was 63.55+/-10.58 vs. 86.05+/-5.75 under GA (P<0.01) and temperature increased in all patients from a baseline of 25.42+/-0.56 up to 32.15+/-0.84 degrees C. All patients undergone LA were discharged the same day after a chest roentgenogram and a short stay in the outpatient clinic. Among them three patients (20%) experienced a minimal (<30%) pneumothorax that required no treatment, while five (33.3%) had a trunk compensatory sweating that spontaneously resolved on the long run. Patients undergoing GA were discharged after a mean stay of 1.38+/-0.6 days. Among these, eight (26.6%) had prolonged trunk compensatory sweating that did not persist longer than 3 months. At a follow-up of 7.16+/-2.97 months, QOL was significantly improved with no difference between groups. The overall rate of satisfaction was greater in the LA group (P<0.05). CONCLUSIONS: In our study, awake one stage bilateral thoracoscopic sympathectomy for palmar hyperhidrosis could be safely and effectively performed as an outpatient procedure in patients refusing GA. Postoperative quality of life was equal to that in patients undergone the same procedure under GA, while patient satisfaction was better and cost were significantly reduced. 相似文献
8.
IgA antiendomysium antibodies in human umbilical cord sections as a screening test in relatives of patients with celiac disease 总被引:1,自引:0,他引:1
M. Bagnasco P. Montagna A. De Alessandri E. Castellano G. P. Pesce R. Gatti 《Allergy》1997,52(10):1017-1021
We performed the serum IgA antiendomysium antibody (EmA) assay by indirect immunofluorescence on human umbilical cord sections in 86 subjects with celiac disease, in 187 first-degree relatives of such patients, and in a control group of 68 unrelated subjects, to investigate the suitability of the method in the screening of populations at risk of gluten sensitivity. Conventional EmA assay using monkey esophagus sections was performed in parallel experiments. The results obtained showed a perfpect correlation between the two methods. All the celiac patients and none of the controls were positive for EmA. EmA positivity was also observed in 11 apparently healthy relatives: intestinal biopsy performed in five of them invariably showed villous atrophy and increase of mucosal lymphocytes. Taking into account the low cost of EmA assay on human umbilical cord, especially when compared to monkey esophagus sections, the method is probably suitable and effective in identifying latent, asymptomatic gluten sensitivity in at-risk populations. 相似文献
9.
A M Gatti 《Journal of biomedical materials research》1987,21(5):603-612
Seven composite materials for dental restorations were examined in order to investigate their color stability. Five of these materials are available for anterior and two for posterior teeth. The change in color was achieved by an accelerated aging test with ultraviolet rays and evaluated, for each material, with the measurement of reflectance. Such measurement was obtained by means of a video display computer working as a computerized photometer. The results show two different types of behavior: some materials turn slightly to yellow, while others bleach. The test was completed with a scanning electron microscope morphologic examination of the surfaces. 相似文献
10.
V Schleyer† S Radakovic-Fijan‡ S Karrer† T Zwingers§ A Tanew‡ M Landthaler† RM Szeimies† 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):823-828
BACKGROUND: Based on good results in the treatment of superficial skin tumours, since the early 1990s topical photodynamic therapy with aminolaevulinic acid (ALA PDT) has been used for disseminated, inflammatory dermatoses including psoriasis. However, there is still a lack of well-documented trials. OBJECTIVE: A prospective randomized, double-blind phase I/II intrapatient comparison study was conducted in 12 patients to investigate whether topical ALA PDT is an effective treatment for chronic plaque-type psoriasis. METHODS: In each patient three psoriatic plaques were randomly treated with a light dose of 20 J/cm(2) and 0.1%, 1% and 5% ALA, respectively. Treatment was conducted twice a week until complete clearance or for a maximum of 12 irradiations. Therapeutic efficacy was assessed by weekly determination of the psoriasis severity index (PSI). RESULTS: The mean percentage improvement was 37.5%, 45.6% and 51.2% in the 0.1%, 1% and 5% ALA-treated groups, respectively. Irradiation had to be interrupted several times because of severe burning and pain sensation. CONCLUSION: Topical ALA PDT did not prove to be an appropriate treatment option for plaque-type psoriasis due to disappointing clinical efficacy, the time-consuming treatment procedure and its unfavourable adverse event profile. 相似文献