全文获取类型
收费全文 | 80篇 |
免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
妇产科学 | 5篇 |
基础医学 | 7篇 |
口腔科学 | 1篇 |
临床医学 | 18篇 |
内科学 | 17篇 |
皮肤病学 | 3篇 |
神经病学 | 3篇 |
外科学 | 10篇 |
综合类 | 1篇 |
预防医学 | 5篇 |
药学 | 5篇 |
肿瘤学 | 1篇 |
出版年
2021年 | 1篇 |
2017年 | 1篇 |
2016年 | 2篇 |
2014年 | 1篇 |
2013年 | 1篇 |
2012年 | 2篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2006年 | 1篇 |
2005年 | 1篇 |
2003年 | 2篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1988年 | 3篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1975年 | 1篇 |
1959年 | 1篇 |
1958年 | 4篇 |
1957年 | 3篇 |
1956年 | 2篇 |
1955年 | 2篇 |
1954年 | 7篇 |
1937年 | 1篇 |
排序方式: 共有82条查询结果,搜索用时 15 毫秒
1.
ARMANDO E. SOTO‐ROJAS MAURICIO ESCOFFIÉ‐RAMÍREZ GLORIANA PÉREZ‐FERRERA JOSEPH A. GUIDO ANDRES A. MANTILLA‐RODRIGUEZ ESPERANZA A. MARTINEZ‐MIER 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2012,22(6):451-458
International Journal of Paediatric Dentistry 2012; 22: 451–458 Background. Dental sealants are an effective treatment for the prevention and management of caries. Objective. To determine the retention of sealants placed in a rural setting in Mexico as part of an international service‐learning (ISL) programme and to determine associations between dental sealant’s retention and caries diagnosis at the time of sealant placement. Methods. Children aged 6–15 were examined for dental caries, received sealants by dental students as part of an ISL programme, and were re‐examined 4, 2, or 1 years after placement to assess sealant survival. Sealants were placed on permanent sound surfaces and enamel caries lesions [International Caries Assessment and Detection System (ICDAS) criteria]. Sealant survival was explored using Cochran–Mantel–Haenszel tests and multivariate prediction models. Results. 219 (46%) of 478 (mean age = 10.53 SD = 5.11) children who had received sealants returned for a recall examination (mean age = 10.89 SD = 3.11). After 1–4 years, 96.4% to 60.6% of the sealants placed on sound teeth had survived, and for sealants placed on surfaces with enamel caries lesions (ICDAS 1–3), 94.2% to 55.6% had survived. Differences were not statistically significant. Conclusions. Sealants had survival rates comparable to those previously reported in the literature. Sealants placed on sound and enamel caries lesions had similar survival rates. 相似文献
2.
LUKAS BUBENDORF GUIDO SAUTER HOLGER MOCH HANS-PETER SCHMID THOMAS C. GASSER PAUL JORDAN MICHAEL J. MIHATSCH 《The Journal of pathology》1996,178(4):437-441
The clinical course of prostate cancer is highly variable and cannot satisfactorily be predicted by histological criteria alone. Both tumour cell proliferation and neuroendocrine differentiation have been suggested as additional prognostic parameters, neuroendocrine differentiation being considered to enhance tumour cell proliferation. This study investigated the prognostic value of tumour cell proliferation [Ki67 labelling index (LI), MIB 1] and neuroendocrine differentiation and their relationship to each other. One hundred and thirty-seven paraffin-embedded radical prostatectomy specimens were examined. Neuroendocrine differentiation was found in 58 per cent of cases, but was not associated with pTN stage, Gleason score, Ki67 LI, or tumour progression. Ki67 LI was not significantly associated with pTN stage or with Gleason score. High grade ( P =0·0005), advanced local stage ( P =0·0004), positive lymph nodes ( P =0·02), and high Ki67 LI ( P =0·0203) were predictors of tumour progression if univariate analysis was performed, but Cox stepwise regression showed that only advanced local stage ( P =0·0025) and Ki67 LI ( P =0·0105) were independent predictors of tumour progression, the relative risk being 3·6 and 2·5, respectively. It is concluded that Ki67 is an important prognostic marker in prostate cancer with a potential for routine application. 相似文献
3.
Severe Spontaneous Echo Contrast/Auricolar Thrombosis in “Nonvalvular” AF: Value of Thromboembolic Risk Scores
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
GIOSUÈ MASCIOLI M.D. F.E.S.C. ELENA LUCCA M.D. FEDERICA MICHELOTTI M.D. GIUSY ALIOTO M.D. FRANCO SANTORO M.D. GUIDO BELLI M.D. CRISTINA ROTA M.D. OMBRETTA ORNAGO M.D. GIOVANNI SIRIANNI M.D. EMANUELA PULCINI M.D. MATTEO PENNESI M.D. CARLO SAVASTA M.D. ROSARIO RUSSO M.D. ANTONINO PITÌ M.D. 《Pacing and clinical electrophysiology : PACE》2017,40(1):57-62
4.
5.
6.
7.
8.
9.
MASSIMO STEFANI GIANNI CAPPUGI LUIGIA PAZZAGLI GUIDO CAMICI GIAMPAOLO MANAO NICCOLO TADDEI MATTHIAS BUCK GIAMPIETRO RAMPONI 《Chemical biology & drug design》1991,38(3):278-284
Previous NMR reports indicated that Tyr98, the C-terminal residue of the muscular form of acylphosphatase, is likely to be part of the enzyme's active site. In addition, there is evidence that an arginine residue participates to the catalyzed reaction, possibly as phosphate binding site. Among all Arg residues present in the muscular forms of acylphosphatase, four, i.e. Arg23, Arg74, Arg77, and Arg97, appear to be conserved in all species checked thus far. We prepared the des-Tyr98 and des-Arg97-Tyr98 derivatives of the native acylphosphatase to investigate the properties of both modified enzymes. The enzyme lacking Tyr98 was found to be catalytically less effective than the native one, whereas the des-Arg97-Tyr98 acylphosphatase was completely inactive. This evidence suggests that Arg97 participates directly to the active site catalytic mechanism. Fluorescence and CD spectra revealed that the latter enzyme could have been undergone some conformational change that could account for the loss of activity; on the other hand, the one-dimensional NMR spectra of either native and des-Arg97-Tyr98 enzymes were strictly similar, thus demonstrating that the removal of the two C-terminal residues does not markedly affect the fold of the enzyme. The results reported are proof of a critical contribution of Arg97 to the acylphosphatase active site; however, we cannot exclude that the function of this residue is merely to stabilize the active site conformation and dynamics. 相似文献
10.
Implantation of a Dual Chamber Pacemaker in a Patient with Persistent Left Superior Vena Cava 总被引:3,自引:0,他引:3
LUC Y. DIRIX IVO E. KERSSCHOT HERBERT EIERENS MARC A. GOETHALS GUY VAN DAELE GUIDO CLAESSEN 《Pacing and clinical electrophysiology : PACE》1988,11(3):343-345
A patient underwent dual chamber pacemaker implantation by puncture of the left subclavian vein. During the procedure we observed persistence of the left superior vena cava. A "J-shaped" atrial lead was used for ventricular pacing with excellent long-term results. This technique can be a valuable alternative when confronted with the problem of persistent left superior vena cava during pacemaker implantation. 相似文献