全文获取类型
收费全文 | 361篇 |
免费 | 39篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 1篇 |
基础医学 | 55篇 |
口腔科学 | 6篇 |
临床医学 | 40篇 |
内科学 | 74篇 |
皮肤病学 | 6篇 |
神经病学 | 25篇 |
特种医学 | 12篇 |
外科学 | 83篇 |
综合类 | 13篇 |
一般理论 | 1篇 |
预防医学 | 19篇 |
眼科学 | 5篇 |
药学 | 14篇 |
中国医学 | 1篇 |
肿瘤学 | 32篇 |
出版年
2023年 | 4篇 |
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 8篇 |
2019年 | 4篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 19篇 |
2015年 | 6篇 |
2014年 | 5篇 |
2013年 | 11篇 |
2012年 | 28篇 |
2011年 | 41篇 |
2010年 | 19篇 |
2009年 | 22篇 |
2008年 | 25篇 |
2007年 | 28篇 |
2006年 | 26篇 |
2005年 | 17篇 |
2004年 | 27篇 |
2003年 | 29篇 |
2002年 | 16篇 |
2001年 | 15篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1977年 | 1篇 |
1966年 | 1篇 |
1937年 | 1篇 |
排序方式: 共有402条查询结果,搜索用时 15 毫秒
1.
2.
美国国立癌症综合信息网头颈肿瘤专家组 《中华口腔医学杂志》2006,41(8):453-455
恶性肿瘤是威胁人类生存的第一杀手,就头颈肿瘤来说虽然发病率在我国并不高,但由于我国人口众多,发病率的绝对数字也是不可忽视的。当今提倡晚期头颈肿瘤的综合序列治疗,患者的生存率及生存质量已有很大的提高,由于我国的地域差异和医学发展水平的不平衡,对于头颈肿瘤的治疗难以形成统一的治疗标准,目前国内也缺少头颈肿瘤的诊断治疗指南,客观存在着肿瘤的诊断治疗欠规范,延误诊治、过度治疗、治疗不够等现状,这不仅导致医疗资源的浪费和国家及个人的经济负担加重,而且由此导致的医患纠纷时有发生。鉴于此,本期刊出由上海交通大学医学院附属第九人民医院·口腔医学院郭伟等医师编译的2005年美国国立癌症综合信息网(National Comprehensive Cancer Network,NCCN)公布的由NCCN头颈肿瘤专家组31位专家撰写的关于头颈部恶性肿瘤诊断治疗指南的有关内容,旨在结合我国实际情况供专业人员参考。 相似文献
3.
The Mouse Secretome: Functional Classification of the Proteins Secreted Into the Extracellular Environment 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Genome research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
Human Disease Genes and Their Cloned Mouse Orthologs: Exploration of the FANTOM2 cDNA Sequence Data Set
下载免费PDF全文
![点击此处可从《Genome research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Genome research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
John C. Reed Kutbuddin Doctor Ana Rojas Juan M. Zapata Christian Stehlik Loredana Fiorentino Jason Damiano Wilfried Roth Shu-ichi Matsuzawa Ruchi Newman Shinichi Takayama Hiroyuki Marusawa Famming Xu Guy Salvesen RIKEN GER Group GSL Members Adam Godzik 《Genome research》2003,13(6B):1376-1388
Apoptosis (programmed cell death) plays important roles in many facets of normal mammalian physiology. Host-pathogen interactions have provided evolutionary pressure for apoptosis as a defense mechanism against viruses and microbes, sometimes linking apoptosis mechanisms with inflammatory responses through NFκB induction. Proteins involved in apoptosis and NFκB induction commonly contain evolutionarily conserved domains that can serve as signatures for identification by bioinformatics methods. Using a combination of public (NCBI) and private (RIKEN) databases, we compared the repertoire of apoptosis and NFκB-inducing genes in humans and mice from cDNA/EST/genomic data, focusing on the following domain families: (1) Caspase proteases; (2) Caspase recruitment domains (CARD); (3) Death Domains (DD); (4) Death Effector Domains (DED); (5) BIR domains of Inhibitor of Apoptosis Proteins (IAPs); (6) Bcl-2 homology (BH) domains of Bcl-2 family proteins; (7) Tumor Necrosis Factor (TNF)-family ligands; (8) TNF receptors (TNFR); (9) TIR domains; (10) PAAD (PYRIN; PYD, DAPIN); (11) nucleotide-binding NACHT domains; (12) TRAFs; (13) Hsp70-binding BAG domains; (14) endonuclease-associated CIDE domains; and (15) miscellaneous additional proteins. After excluding redundancy due to alternative splice forms, sequencing errors, and other considerations, we identified cDNAs derived from a total of 227 human genes among these domain families. Orthologous murine genes were found for 219 (96%); in addition, several unique murine genes were found, which appear not to have human orthologs. This mismatch may be due to the still fragmentary information about the mouse genome or genuine differences between mouse and human repertoires of apoptotic genes. With this caveat, we discuss similarities and differences in human and murine genes from these domain families. 相似文献
6.
Impact on quality of life of a nursing intervention programme for patients with chronic non‐cancer pain: an open,randomized controlled parallel study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
7.
Paul Clarkson MSc PhD Clarissa M. Giebel MSc Matthew Larbey MSc Brenda Roe PhD RN RHV David Challis MSc PhD Jane Hughes BA MSc David Jolley MSc MBBS Medicine Fiona Poland PhD PGCHE Ian Russell MA MSc PhD Members of the HoSt‐D Programme Management Group 《Journal of advanced nursing》2016,72(1):186-196
8.
Guanghui Liang Zhitao Gu Yin Li Jianhua Fu Yi Shen Yucheng Wei Lijie Tan Peng Zhang Yongtao Han Chun Chen Renquan Zhang Keneng Chen Hezhong Chen Yongyu Liu Youbing Cui Yun Wang Liewen Pang Zhentao Yu Xinming Zhou Yangchun Liu Yuan Liu Wentao Fang Members of the Chinese Alliance for Research in Thymomas 《Journal of thoracic disease》2016,8(4):727-737
Background
To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database.Methods
From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis. Cumulative incidence of recurrence (CIR) was assessed in R0 patients. Overall survival (OS) was evaluated both in an R0 resected cohort, as well as in all patients (any R status). CIR and OS were first analyzed according to the Masaoka-Koga staging system. Then, they were compared using the new TNM staging proposal.Results
Based on Masaoka-Koga staging system, significant difference was detected in CIR among all stages. However, no survival difference was revealed between stage I and II, or between stage II and III. Stage IV carried the highest risk of recurrence and worst survival. According to the new TNM staging proposal, CIR in T1a was significantly lower comparing to all other T categories (P<0.05) and there is a significant difference in OS between T1a and T1b (P=0.004). T4 had the worst OS comparing to all other T categories. CIR and OS were significantly worse in N (+) than in N0 patients. Significant difference in CIR and OS was detected between M0 and M1b, but not between M0 and M1a. OS was almost always statistically different when comparison was made between stages I–IIIa and stages IIIb–IVb. However, no statistical difference could be detected among stages IIIb to IVb.Conclusions
Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination. Further study using prospectively recorded information on the proposed TNM categories would be helpful to better grouping thymic tumors for predicting prognosis and guiding clinical management. 相似文献9.
Fangrui Wang Liewen Pang Jianhua Fu Yi Shen Yucheng Wei Lijie Tan Peng Zhang Yongtao Han Chun Chen Renquan Zhang Yin Li Keneng Chen Hezhong Chen Yongyu Liu Youbing Cui Yun Wang Zhentao Yu Xinming Zhou Yangchun Liu Yuan Liu Zhitao Gu Wentao Fang Members of the Chinese Alliance for Research in Thymomas 《Journal of thoracic disease》2016,8(4):711-717
Background
It is so far not clear that how myasthenia gravis (MG) affected the prognosis of thymoma patients. The aim of this assay is to compare the postoperative survival between patients with thymoma only and those with both thymoma and MG.Methods
The Chinese Alliance for Research in Thymomas (ChART) registry recruited patients with thymoma from 18 centers over the country on an intention to treat basis from 1992 to 2012. Two groups were formed according to whether the patient complicated MG. Demographic and clinical data were reviewed, patients were followed and their survival status were analyzed.Results
There were 1,850 patients included in this study, including 421 with and 1,429 without MG. Complete thymectomy were done in 91.2% patients in MG group and 71.0% in non-MG group (P<0.05). There were more percentage of patients with the histology of thymoma AB, B1, or B2 (P<0.05) in MG group, and more percentage of patients with MG were in Masaoka stage I and II. The 5- and 10-year overall survival (OS) rates were both higher in MG group (93% vs. 88%; 83% vs. 81%, P=0.034) respectively. The survival rate was significantly higher in patients with MG when the Masaoka staging was 3/4 (P=0.003). Among patients with advanced stage thymoma (stage 3, 4a, 4b), the constituent ratios of 3, 4a, 4b were similar between MG and non-MG group. Histologically, however, there were significantly more proportion of AB/B1/B2/B3 in the MG group while there were more C in the non-MG group (P=0.000). Univariate analyses for all patients showed that MG, WHO classification, Masaoka stage, surgical approach, chemotherapy and radiotherapy and resectability were significant factors, and multivariate analysis showed WHO classification, Masaoka stage, and resectability were strong independent prognostic indicators.Conclusions
Although MG is not an independent prognostic factor, the survival of patients with thymoma was superior when MG was present, especially in late Masaoka stage patients. Possible reasons included early diagnosis of the tumor, better histologic types, an overall higher R0 resection and less recurrence. 相似文献10.
Qianwen Liu Zhitao Gu Fu Yang Jianhua Fu Yi Shen Yucheng Wei Lijie Tan Peng Zhang Yongtao Han Chun Chen Renquan Zhang Yin Li Keneng Chen Hezhong Chen Yongyu Liu Youbing Cui Yun Wang Liewen Pang Zhentao Yu Xinming Zhou Yangchun Liu Jin Xiang Yuan Liu Wentao Fang Members of the Chinese Alliance for Research in Thymomas 《Journal of thoracic disease》2016,8(4):687-695