全文获取类型
收费全文 | 3966篇 |
免费 | 270篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 123篇 |
妇产科学 | 95篇 |
基础医学 | 404篇 |
口腔科学 | 125篇 |
临床医学 | 539篇 |
内科学 | 750篇 |
皮肤病学 | 154篇 |
神经病学 | 387篇 |
特种医学 | 293篇 |
外科学 | 476篇 |
综合类 | 149篇 |
一般理论 | 2篇 |
预防医学 | 296篇 |
眼科学 | 49篇 |
药学 | 198篇 |
中国医学 | 2篇 |
肿瘤学 | 210篇 |
出版年
2021年 | 57篇 |
2020年 | 35篇 |
2019年 | 66篇 |
2018年 | 56篇 |
2017年 | 45篇 |
2016年 | 61篇 |
2015年 | 60篇 |
2014年 | 77篇 |
2013年 | 138篇 |
2012年 | 166篇 |
2011年 | 172篇 |
2010年 | 129篇 |
2009年 | 124篇 |
2008年 | 164篇 |
2007年 | 185篇 |
2006年 | 171篇 |
2005年 | 170篇 |
2004年 | 142篇 |
2003年 | 149篇 |
2002年 | 142篇 |
2001年 | 138篇 |
2000年 | 164篇 |
1999年 | 96篇 |
1998年 | 82篇 |
1997年 | 70篇 |
1996年 | 59篇 |
1995年 | 51篇 |
1994年 | 56篇 |
1993年 | 62篇 |
1992年 | 65篇 |
1991年 | 67篇 |
1990年 | 68篇 |
1989年 | 83篇 |
1988年 | 66篇 |
1987年 | 74篇 |
1986年 | 56篇 |
1985年 | 57篇 |
1984年 | 43篇 |
1983年 | 36篇 |
1982年 | 24篇 |
1981年 | 31篇 |
1979年 | 27篇 |
1978年 | 29篇 |
1977年 | 25篇 |
1972年 | 27篇 |
1971年 | 26篇 |
1970年 | 26篇 |
1969年 | 24篇 |
1968年 | 24篇 |
1967年 | 27篇 |
排序方式: 共有4260条查询结果,搜索用时 15 毫秒
1.
2.
PT Foley A Ganeshan S Anthony R Uberoi 《Journal of Medical Imaging and Radiation Oncology》2010,54(1):9-16
This is a retrospective review of the results at our institution of using multi-detector CT angiography (CTA) to localise lower gastrointestinal (GI) bleeding. We hypothesised that in our patient population: (i) CTA was unlikely to demonstrate bleeding in patients who were haemodynamically stable; (ii) in haemodynamically unstable patients in whom CTA was undertaken, the results could be used to select patients who would benefit from catheter angiography; and (iii) in haemodynamically unstable patients in whom CTA was undertaken, a subgroup of patients could be identified who would benefit from primary surgical treatment, avoiding invasive angiography completely. A retrospective review was conducted of the clinical records of all patients undergoing CTA for lower GI haemorrhage at our institution between 1 January 2005 and 30 June 2007. Out of the 20 patients examined, 10 had positive CTAs demonstrating the bleeding site. Nine were haemodynamically unstable at the time of the study. Four patients with positive CT angiograms were able to be treated directly with surgery and avoided invasive angiography. Ten patients had negative CTAs. Four of these were haemodynamically unstable, six haemodynamically stable. Only one required intervention to secure haemostasis, the rest stopped spontaneously. No haemodynamically stable patient who had a negative CTA required intervention. CTA is a useful non-invasive technique for localising the site of lower GI bleeding. In our patient population, in the absence of haemodynamic instability, the diagnostic yield of CTA was low and bleeding was likely to stop spontaneously. In haemodynamically unstable patients, a positive CTA allowed patients to be triaged to surgery or angiography, whereas there was a strong association between a negative CTA and spontaneous cessation of bleeding. 相似文献
3.
Keith J Murphy Andrew G Foley Alan W O'connell Ciaran M Regan 《Neuropsychopharmacology》2006,31(1):90-100
Recent data suggest that Alzheimer's patients who discontinue treatment with cholinesterase inhibitors have a significantly delayed cognitive decline as compared to patients receiving placebo. Such observations suggest cholinesterase inhibitors to provide a disease-modifying effect as well as symptomatic relief and, moreover, that this benefit remains after drug withdrawal. Consistent with this suggestion, we now demonstrate that chronic administration of tacrine, nefiracetam, and deprenyl, drugs that augment cholinergic function, increases the basal frequency of dentate polysialylated neurons in a manner similar to the enhanced neuroplasticity achieved through complex environment rearing. While both drug-treated and complex environment reared animals continue to exhibit memory-associated activation of hippocampal polysialylated neurons, the magnitude is significantly reduced suggesting that such interventions induce a more robust memory pathway that can acquire and consolidate new information more efficiently. This hypothesis is supported by our findings of improved learning behavior and enhanced resistance to cholinergic deficits seen following either intervention. Furthermore, the level of enhancement of basal neuroplastic status achieved by either drug or environmental intervention correlates directly with improved spatial learning ability. As a combination of both interventions failed to further increase basal polysialylated cell frequency, complex environment rearing and chronic drug regimens most likely enhanced cognitive performance by the same mechanism(s). These findings suggest that improved memory-associated synaptic plasticity may be the fundamental mechanism underlying the disease modifying action of drugs such as cholinesterase inhibitors. Moreover, the molecular and cellular events underpinning neuroplastic responses are identified as novel targets in the search for interventive drug strategies for the treatment of neurodegenerative and neuropsychiatric disorders. 相似文献
4.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
5.
6.
7.
8.
9.
10.
Brian T. Foley Joan M. Moehring Thomas J. Moehring 《Somatic Cell and Molecular Genetics》1992,18(3):227-231
The histidine residue at position 715 of elongation factor 2 (EF-2) is posttranslationally modified in a series of enzymatic reactions to 2-[3-carboxyamido-3-(trimethylammonio)-propyl]histidine, which has been given the trivial name diphthamide. The diphthamide residue of EF-2 is the target site for ADP ribosylation by diphtheria toxin and Pseudomonas exotoxin A. ADP-ribosylated EF-2 does not function in protein synthesis. EF-2 that has not been posttranslationally modified at histidine 715 is resistant to ADP ribosylation by these toxins. In this report we show that a G-to-A transition in the first position of codon 717 of the EF-2 gene results in substitution of arginine for glycine and prevents addition of the side chain of diphthamide to histidine 715 of EF-2. EF-2 produced by the mutant gene is fully functional in protein synthesis.This work was supported by Public Health Service grant AI-09100 from the National Institute of Allergy and Infectious Diseases and by Biomedical Research Support Grant PHS07RR05429-27. Brian Foley is supported by a Cancer Biology Training Grant T32Ca-09286 from the National Cancer Institute. 相似文献