排序方式: 共有131条查询结果,搜索用时 31 毫秒
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Caputo A. Parente P. Cadei M. Fassan M. Rispo A. Leoncini G. Bassotti G. Del Sordo R. Metelli C. Daperno M. Armuzzi A. Villanacci V. 《Techniques in coloproctology》2022,26(9):713-723
Techniques in Coloproctology - Assessment of mucosal healing is important for the management of patients with inflammatory bowel disease (IBD), but endoscopy can miss microscopic disease areas that... 相似文献
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Pelizzaro Filippo Kitenge Maria Piera Cardin Romilda Ponzoni Alberto Cillo Umberto Vitale Alessandro Businello Gianluca Munari Giada Fassan Matteo Farinati Fabio 《Clinical and experimental medicine》2021,21(4):675-682
Clinical and Experimental Medicine - We aimed to explore the activation of monoacylglycerol lipase (MAGL)/cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) axis in hepatocellular carcinoma (HCC),... 相似文献
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Filippo Pietrantonio Fotios Loupakis Giovanni Randon Alessandra Raimondi Massimiliano Salati Dario Trapani Filippo Pagani Ilaria Depetris Giulia Maddalena Federica Morano Salvatore Corallo Michele Prisciandaro Francesca Corti Vincenzo Guarini Alessandro Bocconi Antonio Marra Carmen Belli Andrea Spallanzani Matteo Fassan Sara Lonardi Giuseppe Curigliano Giovanni Fucà Maria Di Bartolomeo Filippo de Braud 《The oncologist》2020,25(9):803-809
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Fassan M Pizzi M Giacomelli L Mescoli C Ludwig K Pucciarelli S Rugge M 《Virchows Archiv : an international journal of pathology》2011,458(4):413-419
Programmed cell death 4 (PDCD4) has recently been demonstrated to be a new tumor suppressor gene involved in colon carcinogenesis. PDCD4 immunohistochemical
expression was assessed in 300 polypoid lesions of the colon mucosa (50 hyperplastic polyps [HP], 50 serrated adenomas [SA],
50 tubular adenomas with low-grade-intraepithelial neoplasia [LG-IEN], 50 tubular adenomas with high-grade-IEN [HG-IEN]),
and in 50 colon adenocarcinomas (CRC). As normal controls, we considered 50 biopsy samples obtained from patients with irritable
bowel syndrome (N). We further investigated PDCD4 messenger RNA (mRNA) levels by quantitative real-time polymerase chain reaction (PCR) in a different series of N, LG-IEN,
HG-IEN, and CRC biopsy samples. miR-21 expression (an important PDCD4-expression regulator) was also determined by quantitative real-time PCR and in situ hybridization. Normal colocytes and HP
featured strong PDCD4 nuclear immunostaining whereas a significantly lower PDCD4 nuclear expression was observed in dysplasia
(low- and high-grade adenomas and SA) and invasive CRC. PDCD4 immunostaining and mRNA levels decreased significantly as the
phenotypic changes occurring during colon carcinogenesis progressively increased (p < 0.001). As expected, miR-21 expression was significantly upregulated in preneoplastic/neoplastic samples, consistent with PDCD4 downregulation. These results consistently support the use of nuclear PDCD4 immunohistochemical downregulation as a novel
biomarker for the diagnosis of dysplastic/neoplastic lesions in colon biopsy samples. 相似文献
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BACKGROUND: Squamous cell carcinoma accounts for 1% of primary thyroid malignancies and is characterized by a rapidly unfavorable outcome. CASE PRESENTATION: A 64-year-old woman presented with a painless mass in the left neck, coexisting with thyroid goiter. Total thyroidectomy with lymphadenectomy was performed and a primary thyroid squamous cell cancer was confirmed histologically after excluding any other possible primary malignancies. The tumor's immunohistochemical profile was explored using a large panel of antibodies. The tumor featured a positive immunoreaction to cytokeratins 7-19 and to squamous cell carcinoma antigen. Low-molecular-weight cytokeratins 5-6 and epithelial membrane antigen were also expressed. The neoplasm's proliferative index (Mib1) was 60%. No immunostaining was detected for cytokeratins 10-20, thyroglobulin, TTF-1, CD5, galectin-3 or p53. CONCLUSIONS: This case of primary thyroid squamous cell carcinoma immunohistochemically profiled using a large panel of immunoreactions may offer useful information on the histological differentiation of thyroid squamous cell carcinoma from other (uncommon) thyroid carcinomas and the distinction between primary and secondary thyroid cancers. 相似文献