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Moeenaldeen Al-Sayed Faiqa Imtiaz Osama A Alsmadi Mohammed S Rashed Brian F Meyer 《BMC medical genetics》2006,7(1):86-5
Background
3-Hydroxy-3-Methylglutaric aciduria (3HMG, McKusick: 246450) is an autosomal recessive branched chain organic aciduria caused by deficiency of the enzyme 3-Hydroxy-3-Methylglutaryl CoA lyase (HL, HMGCL, EC 4.1.3.4). HL is encoded by HMGCL gene and many mutations have been reported. 3HMG is commonly observed in Saudi Arabia. 相似文献3.
1 BACKGROUNDTheincidenceofCPis 0 .7per 1 0 0 0livebirths[1 ] .Becausecerebralpalsyinfluencesthewaychildrendevelop,itoftenresultsindevelop mentaldisability .Today ,more peoplehavecerebralpalsythananyotherdevelopmentaldis ability ,includingDownsyndrome,epilepsy ,andautism .Accordingtoasurveyconductedin1 986,2 .6%ofthepopulationofPakistaniaredisabled (includingbothphysicalandmentaldis abilities) .Childrenbetween 0~1 4 yearsinageconstitute 40 %ofthedisabled populationinPakistan .Routineme… 相似文献
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There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents. In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural compounds for chemoprevention and chemotherapy of prostate cancer, the state of the art nanotherapeutics and the recent proof-of-concept of “nanochemoprevention”, as well as the clinical development of promising targeted nanoprototypes for use in the prostate cancer treatment are being discussed. 相似文献
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Edwards Richard Greenwood Hannah E. McRobbie Graeme Khan Imtiaz Witney Timothy H. 《Molecular imaging and biology》2021,23(6):854-864
Molecular Imaging and Biology - (S)-4-(3-18F-Fluoropropyl)-?-Glutamic Acid ([18F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography (PET) imaging of... 相似文献
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Muhammad Imtiaz Ahmad Yabing Li Elsayed Z. Soliman 《Journal of electrocardiology》2018,51(6):1125-1130
Objective
Increasing evidence doubts the benign nature of metabolically healthy obesity (MHO). An investigation of the association of MHO and other obesity phenotypes with electrocardiographic left ventricular hypertrophy (ECG-LVH), a risk factor for cardiovascular disease (CVD), can give insight into the pathophysiological basis for increased risk of CVD linked to these phenotypes.Methods
This analysis included 3997 participants (58.7?±?13.6?years; 51.8% women) without CVD from the NHANES-III. Metabolic syndrome was defined according to the Adult Treatment Panel III. Obesity was defined as body mass index ≥30?kg/m2. Multivariable logistic regression was used to examine the cross-sectional association between 4 obesity phenotypes (metabolically healthy non-obese (MHNO) (reference), metabolically unhealthy non-obese (MUNO), MHO and metabolically unhealthy obese (MUO) with Cornell voltage ECG-LVH.Results
There was an incremental increase in the prevalence of ECG-LVH across obesity phenotypes with the highest prevalence in the MUO followed by MHO, MUNO and then MHNO (ECG-LVH?=?6.45%, 5%, 4.71%, and 1.69%, respectively, trend p-value?<?0.001). Also, there was incremental increase in the strength of associations with ECG-LVH across obesity phenotypes with higher odds of ECG-LVH in the MUO (OR (95% CI): 4.12 (2.30–7.39) followed by MUNO (OR (95% CI): 2.62 (1.45–4.73) then MHO (OR (95% CI): 2.45 (1.11–5.43) compared to MHNO. The MHO association with ECG-LVH was stronger in men than women (OR (95% CI): 5.55 (1.49–20.70) vs. 1.94 (0.71–5.24) respectively; interaction p-value?=?0.04).Conclusions
Obesity phenotypes including MHO are associated with ECG-LVH, thus further questioning the concept of benign obesity. 相似文献9.
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