Assessment of PACS Display Systems

This work describes our experience in reviewing the performance criteria for display systems and how we have implemented a practical approach to the assessment of the workstation environment in a large tertiary care hospital. The acceptance criteria contained in the draft report of Topic Group 18 of the American Association of Physicists in Medicine (AAPM) were used as a basis for assessment of primary and secondary displays. A telescopic photometer was used to measure the maximum luminance and the contrast ratio of the image for the displays used in our radiology department and in the operating and emergency rooms using the standard Society of Motion Picture and Television Engineers (SMPTE) pattern, in ambient light and with light decreased as much as possible. About half of the displays met the AAPM criteria for minimum luminance and contrast ratio in low light. None of the systems met the contrast ratio criteria in ambient light. The challenges in improving the performance and calibrating displays are discussed.     

The Detectability and Localization Accuracy of Implanted Fiducial Markers Determined on In-Room Computerized Tomography (CT) and Electronic Portal Images (EPI)

Many different methods of image guidance are available for radiotherapy treatment (IGRT). The aims of the study were (1) to determine the optimal diameter of gold markers for IGRT to the prostate; (2) to compare, using the Siemens Primatom, the relative merits of in-room computerized tomography (CT) and electronic portal image (EPI) for locating the marker seeds. Gold markers of differing widths were embedded in 2 phantoms (perspex slabs and anthropomorphic). Images were acquired with an amorphous silicon flat panel detector (Siemens Optivue 500) and with the in-room CT scanner (Siemens Somatom Balance). The EPIs were reviewed independently by 6 operators to determine which diameter marker could be best visualized. The optimal marker technique was determined by comparing the investigators' observed marker co-ordinates with the known locations within the phantom. The visibility of all markers on anterior-posterior EPIs was 100%. On the lateral EPI, of a possible 180 visualizations of 1.2-, 1.0-, and 0.8-mm diameter markers, 176 (97.8%), 151 (83.9%), and 132 (73.3%), respectively, were successful. On EPI, the average deviation of fiducial markers from the known position was less than 0.5 mm in any direction. On CT, the largest deviation (2.17 mm) of markers from the known coordinate position was in the superior-inferior direction, reflecting the 3.0-mm slice thickness used. EPI accurately located internal markers in all dimensions. The availability of “gold standard” CT imagery at the treatment unit does not improve how accurately the position of markers in a phantom can be defined compared with EPI. However, CT imagery does provide important soft tissue information, the benefits of which are being investigated further.     

Dosimetric Verification of Intensity Modulated Radiation Therapy of 172 Patients Treated for Various Disease Sites: Comparison of EBT Film Dosimetry, Ion Chamber Measurements, and Independent MU Calculations

Three independent dose verification methods for intensity modulated radiation therapy (IMRT) were evaluated. Planar IMRT dose distributions were delivered to EBT film and scanned with the Epson Expression 1680 flatbed scanner. The measured dose distributions were then compared to those calculated with a Pinnacle treatment planning system. The IMRT treatments consisted of 7 to 9 6-MV beams for different treatment sites. The films were analyzed using FilmQA (3cognition LLC, Great Neck, NY) software. Comparisons between measured and calculated dose distributions are reported as dose difference (DD) (pixels within ± 5%), distance to agreement (DTA) (3 mm), as well as gamma values (γ) (dose = ± 3%, distance = 2 mm). Point dose measurements with an ion chamber at isocenter were compared to dose calculated at that point. An independent monitor units (MUs) calculation program was also used for verification. For the film dose distributions, DD values varied from 92% to 97%, with head-and-neck and lung treatments showing lower values. Gamma varied from 93% to 98%, and DTA was well above 99%. The isocenter dose measurements deviated from 0.008 to 0.028 from the calculated dose. The larger deviations were attributed to high-dose gradients at the isocenter. RadCalc MU calculations gave differences from 0.027 to 0.079. The larger differences observed were for beams crossing large areas of heterogeneous tissue and were attributed to the limitations of the simple path-length correction method employed in RadCalc. In conclusion, the 3 independent verification methods for each IMRT patient at our institution demonstrated very good agreement between measurements and calculations and gave us the confidence that our IMRT treatments are delivered accurately.     

High rates of tumor growth and disease progression detected on serial pretreatment fluorodeoxyglucose‐positron emission tomography/computed tomography scans in radical radiotherapy candidates with nonsmall cell lung cancer

BACKGROUND:

The authors studied growth and progression of untreated nonsmall cell lung cancer (NSCLC) by comparing diagnostic and radiotherapy (RT) planning fluorodeoxyglucose (FDG)‐positron emission tomography (PET)/computed tomography (CT) scans before proposed radical chemo‐RT.

METHODS:

Patients enrolled on a prospective clinical trial were eligible for this analysis if they underwent 2 pretreatment whole body FDG‐PET/CT scans, >7 days apart. Scan 1 was performed for diagnosis/disease staging and scan 2 for RT planning. Interscan comparisons included disease stage, metabolic characteristics, tumor doubling times, and change in treatment intent.

RESULTS:

Eighty‐two patients underwent planning PET/CT scans between October 2004 and February 2007. Of these, 28 patients (61% stage III, 18% stage II) had undergone prior staging PET/CT scans. The median interscan period was 24 days (range, 8‐176 days). Interscan disease progression (TNM stage) was detected in 11 (39%) patients. The probability of upstaging within 24 days was calculated to be 32% (95% confidence interval [CI], 18%‐49%). Treatment intent changed from curative to palliative in 8 (29%) cases, in 7 because of PET. For 17 patients who underwent serial PET/CT scans under standardized conditions, there was a mean relative interscan increase of 19% in tumor maximum standardized uptake value (SUV) (P = .022), 16% in average SUV (P = .004), and 116% in percentage injected dose (P = .002). Estimated doubling time of FDG avid tumor was 66 days (95% CI, 51‐95 days).

CONCLUSIONS:

Rapid tumor progression was detected in patients with untreated, predominantly stage III, NSCLC on serial FDG‐PET/CT imaging, highlighting the need for prompt diagnosis, staging, and initiation of therapy in patients who are candidates for potentially curative therapy. Cancer 2010. © 2010 American Cancer Society.     

Study on surface dose generated in prostate intensity-modulated radiation therapy treatment

The surface doses of 6- and 15-MV prostate intensity-modulated radiation therapy (IMRT) irradiations were measured and compared to those from a 15-MV prostate 4-beam box (FBB). IMRT plans (step-and-shoot technique) using 5, 7, and 9 beams with 6- and 15-MV photon beams were generated from a Pinnacle treatment planning system (version 6) using computed tomography (CT) scans from a Rando Phantom (ICRU Report 48). Metal oxide semiconductor field effect transistor detectors were used and placed on a transverse contour line along the Phantom surface at the central beam axis in the measurement. Our objectives were to investigate: (1) the contribution of the dynamic multileaf collimator (MLC) to the surface dose during the IMRT irradiation; (2) the effects of photon beam energy and number of beams used in the IMRT plan on the surface dose. The results showed that with the same number of beams used in the IMRT plan, the 6-MV irradiation gave more surface dose than that of 15 MV to the phantom. However, when the number of beams in the plan was increased, the surface dose difference between the above 2 photon energies became less. The average surface dose of the 15-MV IMRT irradiation increased with the number of beams in the plan, from 0.86% to 1.19%. Conversely, for 6 MV, the surface dose decreased from 1.33% to 1.24% as the beam number increased from 7 to 9. Comparing the 15-MV FBB and 6-MV IMRT plans with 2 Gy/fraction, the IMRT irradiations gave generally more surface dose, from 15% to 30%, depending on the number of beams in the plan. It was found that the increase in surface dose for the IMRT technique compared to the FBB plan was predominantly due to the number of beams and the calculated monitor units required to deliver the same dose at the isocenter in the plans. The head variation due to the dynamic MLC movement changing the surface dose distribution on the patient was reflected by the IMRT dose-intensity map. Although prostate IMRT in this study had an average higher surface dose than that of FBB, the more even distribution of relatively lower surface dose in IMRT field could avoid the big dose peaks at the surface positions directly under the FBB fields. Such an even and low surface dose distribution surrounding the patient in IMRT is believed to give less skin complication than that of FBB with the same prescribed dose.     

Comparison of attenuation, dual-energy-window, and model-based scatter correction of low-count SPECT to 82Rb PET/CT quantified myocardial perfusion scores

Background

New reconstruction algorithms allow reduction in acquisition times or the amount of injected radioactivity. We examined the impact of different corrections on low-count clinical SPECT myocardial perfusion images (MPI) and compared to ⁸²Rb PET/CT. We compared no corrections (NC) to attenuation correction (AC) with and without scatter correction by either a dual-energy-window (AC-DEW) or model-based (AC-ESSE) approach. All reconstructions included resolution recovery.

Methods

56 Patients were imaged using a standard rest/stress Tc-99m-tetrofosmin MPI SPECT/CT protocol with an additional half-time acquisition. A ⁸²Rb-rest/stress PET/CT MPI was acquired within 4 weeks. Reconstruction methods were compared using summed rest/stress/difference scores from an objective algorithm (SRS/SSS/SDS).

Results

The SRS and SSS for NC were significantly (P < .01) higher than for AC, but well correlated (r ≥ 0.87). The correlation in SRS/SSS among AC, AC-DEW, and AC-ESSE was excellent (r ≥ 0.98). AC-ESSE and AC-DEW had higher SRS (P ≤ .05) than AC, but the SDS values were not significantly different. Concordance with PET normal/abnormal classification was 76% for NC and ≥85% for the AC methods.

Conclusion

AC significantly improves the accuracy of low-count myocardial perfusion SPECT half-time imaging for the detection of disease compared to NC. Compared to PET, there was no significant difference among AC, AC-DEW, and AC-ESSE.     

Planar radionuclide angiography with a dedicated cardiac SPECT camera

Background

We compared a dedicated cardiac camera with a traditional system for left ventricular (LV) functional measurements using gated blood-pool imaging.

Methods

24-frame gated planar images were obtained from 48 patients in an LAO orientation for 6M counts/view on a standard gamma camera. Immediately thereafter, 24-frame ECG-gated data were obtained for 8 minutes on a dedicated cardiac SPECT camera. The gated SPECT image volumes were iteratively reconstructed and then transferred offline. In-house software was used to reproject the images into a 24-frame gated planar format. Both the original and the reprojected gated planar datasets were analyzed using semiautomated software to determine ejection fraction (EF), ventricular volume (end diastolic volume, EDV), peak ejection rate (PER), and peak filling rate (PFR).

Results

The difference in EF values averaged 0.4% ± 4.4%. The correlation in EF was r ≥ 0.94 (P < .01) with a linear regression slope of 0.98. Correlation of the EDV was r ≥ 0.86 (P < .01), but the volumes from the dedicated cardiac camera were smaller (linear regression slope was 0.6). Correlation of PFR and PER were r = 0.91 and r ≥ 0.83, respectively (P < .01 for both).

Conclusions

Reprojection of 24-frame gated blood-pool SPECT images is an effective means of obtaining LV functional measurements with a dedicated cardiac SPECT camera using standard 2D-planar analysis tools.     

Study on surface dose generated in prostate intensity-modulated radiation therapy treatment

The surface doses of 6- and 15-MV prostate intensity-modulated radiation therapy (IMRT) irradiations were measured and compared to those from a 15-MV prostate 4-beam box (FBB). IMRT plans (step-and-shoot technique) using 5, 7, and 9 beams with 6- and 15-MV photon beams were generated from a Pinnacle treatment planning system (version 6) using computed tomography (CT) scans from a Rando Phantom (ICRU Report 48). Metal oxide semiconductor field effect transistor detectors were used and placed on a transverse contour line along the Phantom surface at the central beam axis in the measurement. Our objectives were to investigate: (1) the contribution of the dynamic multileaf collimator (MLC) to the surface dose during the IMRT irradiation; (2) the effects of photon beam energy and number of beams used in the IMRT plan on the surface dose. The results showed that with the same number of beams used in the IMRT plan, the 6-MV irradiation gave more surface dose than that of 15 MV to the phantom. However, when the number of beams in the plan was increased, the surface dose difference between the above 2 photon energies became less. The average surface dose of the 15-MV IMRT irradiation increased with the number of beams in the plan, from 0.86% to 1.19%. Conversely, for 6 MV, the surface dose decreased from 1.33% to 1.24% as the beam number increased from 7 to 9. Comparing the 15-MV FBB and 6-MV IMRT plans with 2 Gy/fraction, the IMRT irradiations gave generally more surface dose, from 15% to 30%, depending on the number of beams in the plan. It was found that the increase in surface dose for the IMRT technique compared to the FBB plan was predominantly due to the number of beams and the calculated monitor units required to deliver the same dose at the isocenter in the plans. The head variation due to the dynamic MLC movement changing the surface dose distribution on the patient was reflected by the IMRT dose-intensity map. Although prostate IMRT in this study had an average higher surface dose than that of FBB, the more even distribution of relatively lower surface dose in IMRT field could avoid the big dose peaks at the surface positions directly under the FBB fields. Such an even and low surface dose distribution surrounding the patient in IMRT is believed to give less skin complication than that of FBB with the same prescribed dose.