全文获取类型
收费全文 | 2449篇 |
免费 | 152篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 83篇 |
妇产科学 | 69篇 |
基础医学 | 359篇 |
口腔科学 | 44篇 |
临床医学 | 217篇 |
内科学 | 539篇 |
皮肤病学 | 33篇 |
神经病学 | 236篇 |
特种医学 | 35篇 |
外科学 | 198篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 207篇 |
眼科学 | 68篇 |
药学 | 293篇 |
中国医学 | 12篇 |
肿瘤学 | 206篇 |
出版年
2024年 | 5篇 |
2023年 | 19篇 |
2022年 | 34篇 |
2021年 | 92篇 |
2020年 | 54篇 |
2019年 | 95篇 |
2018年 | 92篇 |
2017年 | 55篇 |
2016年 | 71篇 |
2015年 | 79篇 |
2014年 | 110篇 |
2013年 | 130篇 |
2012年 | 200篇 |
2011年 | 167篇 |
2010年 | 108篇 |
2009年 | 95篇 |
2008年 | 169篇 |
2007年 | 145篇 |
2006年 | 142篇 |
2005年 | 131篇 |
2004年 | 127篇 |
2003年 | 105篇 |
2002年 | 95篇 |
2001年 | 28篇 |
2000年 | 27篇 |
1999年 | 28篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 10篇 |
1995年 | 14篇 |
1994年 | 6篇 |
1993年 | 14篇 |
1992年 | 22篇 |
1991年 | 18篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 5篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1982年 | 6篇 |
1980年 | 5篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1968年 | 3篇 |
1924年 | 4篇 |
排序方式: 共有2610条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Angelo M. Carella Sandro Nati Paolo Carlier Daniela Pierluigi Domenico Giordano Angela Congiu Gino Santini Daniele Scarpati Salvina Barra Renzo Corvo Vito Vitale Maria R. Raffo Raffaella Cerri Marco Risso Mauro Spriano Renato Vimercati Ester Pungolino Andrea Bacigalupo Eugenio Damasio 《Leukemia & lymphoma》1991,5(1):43-47
Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT.
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
5.
Lp(a) lipoprotein in cerebrovascular disease and dementia 总被引:1,自引:0,他引:1
Lp(a) lipoprotein has been considered an independent risk factor in the development of coronary heart disease (CHD). We examined the role of Lp(a) in patients with cerebrovascular disease (CVD) and those with dementia. The Lp(a) concentration in patients with CHD, those with cerebral infarction due to a large artery occlusion and those with vascular dementia (VD) was significantly higher than that of age-matched control subjects. However, the Lp(a) concentration was not high in cerebral infarction due to a small artery occlusion, intracerebral hemorrhage and dementia of the Alzheimer type (DAT). The present results suggest that Lp(a) should cause VD as well as CVD, and that Lp(a) should be one of the indicators that distinguish VD from DAT. 相似文献
6.
7.
Debora Steiner Tomer Avidor-Reiss Ester Schallmach Daniella Saya Zvi Vogel 《Journal of molecular neuroscience : MN》1996,27(2):195-203
It was shown previously that chronic exposure to opiate agonists increases adenylyl cyclase (AC) activity, a phenomenon termed
AC superactivation (or supersensitization). More recently, we showed that acute Gi/o-coupled receptor activation inhibits the activity of several AC isozymes, including Ca2+/calmodulin-stimulated AC-I and -VIII, whereas chronic receptor activation induces their superactivation. Here, we report
that both acute μ-opioid receptor-induced inhibition and chronic induced superactivation of AC-I and -VIII are pertussis toxin
sensitive. In addition, we show that proteins that interfere with the activity of {ie195-2} subunits ({ie195-3} scavengers)
strongly attenuate the acute inhibition of AC-I and -VIII and the superactivation of AC-I, and abolish the superactivation
of AC-VIII. Based on these results, we suggest that {ie195-4} is involved in the acute inhibition and chronic agonist-induced
superactivation of AC types I and VIII. 相似文献
8.
A M Yamamoto C Mura M G Morales O Bernard R Krishnamoorthy F Alvarez 《Clinical and experimental immunology》1992,87(2):251-255
Cytochrome P450 IID6 is an autoantigen recognized by the sera of children affected with a subtype of autoimmune hepatitis. It was hypothesized that a mutation in the CYP2D6 gene could explain the autoimmune response in these patients. To examine this question, genomic DNA from peripheral lymphocytes (n = 9) and liver (n = 1) of 10 patients with anti-LKM-1 antibody was analysed by Southern blot for genetic association studies between a particular CYP2D6 haplotype and autoimmune hepatitis. In addition, a region of CYP2D6, from the same genomic DNA, was amplified by polymerase chain reaction (PCR) and digested by BstNI, in a search for the most prevalent 29B mutation, described in subjects who do not express the P450 IID6. Total RNA and proteins, prepared from the liver of an anti-LKM-1+ patient, were analysed by Northern and Western (immunoblot) blots respectively. Our results do not reveal any major structural change in the DNA of this patient at the CYP2D6 locus that could explain their autoimmune response. Corroborating this observation, no changes were noted either in P450 IID6 mRNA size or in the corresponding protein. However, these data do not exclude the possibility of subtle changes in the protein due to point mutations in critical regions that might trigger an autoimmune response. 相似文献
9.
Helen He Ester Del Duca Aisleen Diaz Hyun Je Kim Jesús Gay-Mimbrera Ning Zhang Jianni Wu Jessica Beaziz Yeriel Estrada James G. Krueger Ana B. Pavel Juan Ruano Emma Guttman-Yassky 《The Journal of allergy and clinical immunology》2021,147(4):1369-1380
- Download : Download high-res image (227KB)
- Download : Download full-size image
10.
Donnadieu E Jouvin MH Rana S Moffatt MF Mockford EH Cookson WO Kinet JP 《Immunity》2003,18(5):665-674
Allergic reactions are triggered via crosslinking of the high-affinity receptor for immunoglobulin E, F(c)epsilonRI. In humans, F(c)epsilonRI is expressed as a tetramer (alphabetagamma(2)) and a trimer (alphagamma(2)). The beta subunit is an amplifier of F(c)epsilonRI surface expression and signaling. Here, we show that as a consequence of alternative splicing, the F(c)epsilonRIbeta gene encodes two proteins with opposing and competing functions. One isoform is the full-length classical beta, the other a novel truncated form, beta(T). In contrast to beta, beta(T) prevents F(c)epsilonRI surface expression by inhibiting alpha chain maturation. Moreover, beta(T) competes with beta to control F(c)epsilonRI surface expression in vitro. We propose that the relative abundance of the products of the beta gene may control the level of F(c)epsilonRI surface expression and thereby influence susceptibility to allergic diseases. 相似文献