全文获取类型
收费全文 | 3172篇 |
免费 | 168篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 176篇 |
妇产科学 | 131篇 |
基础医学 | 259篇 |
口腔科学 | 139篇 |
临床医学 | 243篇 |
内科学 | 694篇 |
皮肤病学 | 27篇 |
神经病学 | 174篇 |
特种医学 | 145篇 |
外科学 | 736篇 |
综合类 | 39篇 |
预防医学 | 123篇 |
眼科学 | 42篇 |
药学 | 123篇 |
中国医学 | 12篇 |
肿瘤学 | 244篇 |
出版年
2023年 | 38篇 |
2022年 | 22篇 |
2021年 | 70篇 |
2020年 | 45篇 |
2019年 | 55篇 |
2018年 | 84篇 |
2017年 | 83篇 |
2016年 | 63篇 |
2015年 | 102篇 |
2014年 | 115篇 |
2013年 | 158篇 |
2012年 | 250篇 |
2011年 | 230篇 |
2010年 | 117篇 |
2009年 | 105篇 |
2008年 | 172篇 |
2007年 | 206篇 |
2006年 | 172篇 |
2005年 | 186篇 |
2004年 | 185篇 |
2003年 | 211篇 |
2002年 | 201篇 |
2001年 | 80篇 |
2000年 | 94篇 |
1999年 | 62篇 |
1998年 | 23篇 |
1997年 | 26篇 |
1996年 | 18篇 |
1995年 | 17篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 12篇 |
1988年 | 5篇 |
1987年 | 6篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1982年 | 5篇 |
1981年 | 7篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1971年 | 3篇 |
1966年 | 5篇 |
1964年 | 3篇 |
排序方式: 共有3349条查询结果,搜索用时 453 毫秒
1.
Emile Gogineni Zaker Rana Michael Wotman Jessie Karten Adam Riegel Mihaela Marrero Luis Maduro Dev Kamdar Douglas Frank Doru Paul Nagashree Seetharamu Maged Ghaly 《Journal of Geriatric Oncology》2021,12(1):122-127
PurposeManagement of head and neck cancers (HNC) in older adults is a common but challenging clinical scenario. We assess the impact of Stereotactic Body Radiation Therapy (SBRT) on survival utilizing the Geriatric-8 (G8) questionnaire.Materials and methods171 HNC patients, deemed medically unfit for definitive treatment, were treated with SBRT ± systemic therapy. G8 questionnaires were collected at baseline, at 4–6 weeks, and at 2–3 months post-treatment. Patients were stratified according to their baseline G8 score: <11 as ‘vulnerable’, 11–14 as ‘intermediate’, and >14 as ‘fit’. Overall survival (OS) was assessed through univariate Kaplan Meier analysis. Repeated measures ANOVA was used to determine if baseline characteristics affected G8 score changes.ResultsMedian follow-up was seventeen months. 60% of patients presented with recurrent HNC, 30% with untreated HNC primaries, and 10% with metastatic non-HNC primaries. Median age was 75 years. Median Charlson Comorbidity Index score was 2. 51% of patients were ‘vulnerable’, 37% were ‘intermediate’, and 12% were ‘fit' at baseline, with median survival of 13.2, 24.3, and 41.0 months, respectively (p = .004). Patients who saw a decrease in their follow-up G8 score (n = 69) had significantly lower survival than patients who had stable or increased follow-up G8 scores (n = 102), with median survival of 8.6 vs 36.0 months (p < .001).ConclusionThe G8 questionnaire may be a useful tool in upfront treatment decision-making to predict prognosis and prevent older patients from receiving inappropriate anti-cancer treatment. Decline in follow-up G8 scores may also predict worse survival and aid in goals of care following treatment. 相似文献
2.
3.
T. Aköz B. Erdoğan M. Görgü M. R. Kapucu O. Girgin 《European journal of plastic surgery》1998,21(6):308-310
Camptodactyly is a flexion deformity of the proximal interphalangeal joint. Because of unsatisfactory results, treatment is
not recommended for mild deformities, and in severe deformities surgery has been disappointing. A specially designed external
fixator providing gradual distraction was used in a severe case. With this mildly aggressive method, an acceptable result
was obtained.
Received: 5 June 1997/Accepted: 2 February 1998 相似文献
4.
Cemal Şenyuva Akın Yücel Yagmur Aydın Ihsan Okur Zeki Güzel 《Aesthetic plastic surgery》1997,21(4):233-239
Extracorporeal septoplasty is a radical solution for the severely deviated nose. The major problems associated with this
procedure are fixation of the septal cartilage graft and dorsal irregularities. Extracorporeal septoplasty was performed in
combination with open rhinoplasty in 17 patients with severe nasal deformities. In this technique septum was totally removed
through the columellar incision of open rhinoplasty, corrected outside, and replaced as a free ``L' shaped cartilage graft.
The cartilage graft was fixated to the upper lateral cartilages to restore the natural relations of the anatomical structures.
Additional rhinoplastic manipulations were also performed. The follow-up period was up to 18 months. The overall result was
successful in all patients. Nasal deviation did not recur and secondary revisions were not needed for any patient during follow-up. 相似文献
5.
6.
H H Vincent E Ak?ahuseyin M C Vos F J van Ittersum W A van Duyl M A Schalekamp 《Nephrology, dialysis, transplantation》1990,5(12):1031-1037
In continuous arteriovenous haemofiltration (CAVH) or haemodiafiltration (CAVHD), it is important to obtain an adequate blood flow through the haemofilter to minimise the risk of excessive haemoconcentration and clotting. In this study we determined the resistance to blood flow of the extracorporeal device as well as the hydraulic permeability of the filter membrane is intensive care patients treated with CAVHD. Data were obtained for CAVH catheters and Scribner shunts and for a polyacrylonitrile (AN-69) plate filter, an AN-69 capillary filter and a polysulphone (PS) capillary filter. In accordance with recent literature we also predicted the resistance to flow by using Poiseuille's law and a formula for the estimation of blood viscosity. Although with all three filters an adequate blood flow was usually obtained, the resistance to blood flow was 2-3 times greater than the predicted value. With continued use of the filter, resistance to blood flow remained largely unchanged. When, in the laboratory, the AN-69 capillary filter was perfused with saline and with a viscous sucrose solution, the resistance to flow was only 1.4 time the predicted value, a difference that might result from small deviations of the capillary diameter. When perfused with blood, the resistance was 2.6 times greater than the predicted value. This was largely explained by gross underestimation of blood viscosity in these patients. By combining laboratory data on filter resistance during saline perfusion and a more accurate estimation of blood viscosity, a reasonably accurate prediction of blood flow rate would be feasible. In the clinic the hydraulic permeability of the filters decreased with time.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
7.
8.
Correlation of P-selectin and lipoprotein(a), and other lipid parameters in preeclampsia 总被引:1,自引:0,他引:1
Preeclampsia is a pregnancy specific disorder and is thought to be associated with generalized endothelial dysfunction. P-selectin,
an adhesion molecule, mediates the interaction of monocytes, platelets, and endothelial cells. Increased P-selectin levels
and altered lipid and lipoprotein metabolism were reported in preeclampsia and during pregnancy. In order to investigate
the relationship between serum P-selectin and lipoprotein(a), and other lipid parameters, 28 preeclampsia [13 severe (group
I) and 15 mild preeclampsia (group II), 15 healthy pregnant (group III) and 20 non-pregnant (group IV)] women were investigated.
Serum P-selectin, lipoprotein(a), total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured
and low-density lipoprotein cholesterol was derived. Serum P-selectin concentrations were consistently and significantly higher
in the severe preeclampsia group than in the mild preeclampsia, healthy pregnancy, and non-pregnant control groups (P<0.0001, for all). The mild preeclampsia group also had increased serum P-selectin concentrations compared with the healthy
pregnancy group and non-pregnant controls (P<0.05 and P<0.0001, respectively). Serum P-selectin and lipoprotein(a) levels revealed a significant and linear increase with the severity
of preeclampsia. There were also significant (in groups I and II) and borderline (in groups III and IV) correlations between
P-selectin and total cholesterol. The present study suggests that P-selectin may be an additional risk marker for preeclampsia,
and may be useful in distinguishing women with mild and severe preeclampsia and normal pregnancy.
Received: 9 November 2001 / Accepted: 6 February 2002 相似文献
9.
H. Böhles O. J. Beifuss U. Brandl J. Pichl Z. Akçetin L. Demling 《Journal of molecular medicine (Berlin, Germany)》1988,66(3):87-91
Summary An increased frequency of kidney stone formation is reported in patients with inflammatory bowel disease. In order to investigate its pathogenesis, the concentrations of factors known to enhance calcium oxalate stone formation (oxalate, calcium, uric acid) as well as of inhibitory factors for nephrolithiasis (magnesium, citrate) were determined in the urine of 86 patients with Crohn's disease and compared with those of 53 metabolically healthy controls. Six patients with Crohn's disease already had experienced calcium oxalate nephrolithiasis. Patients with Crohn's disease had significantly higher urinary oxalate and lower magnesium and citrate concentrations. Among all patients magnesium and citrate were significantly lower in those with a positive history of kidney stones. Our results demonstrate that the increased propensity for renal stone formation in patients with Crohn's disease is a result not only of increased urinary oxalate, but also of decreased urinary magnesium and citrate concentrations.Abbreviations CDAI
Crohn's disease activity index
Dedicated to Professor Dr. N. Zöllner on the occasion of his 65th birthday 相似文献
10.