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1.
Ali Z Tanaka T Iliya I Iinuma M Furusawa M Ito T Nakaya K Murata J Darnaedi D 《Journal of natural products》2003,66(4):558-560
Four new phenolic derivatives, gnetofurans A-C (1-3) and dihydropinosylvindiol (4), were isolated from a methanol-soluble extract of the stems of Gnetum klossii, together with nine known compounds [gnetifolin F (5), isorhapontigenin, gnetulin, gnetins E and C, latifolol, gnetol, (-)-epsilon-viniferin, and trans-resveratrol]. The structures of the new compounds were determined by spectral data analysis. 相似文献
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Claudia Christine Sidler-Maier Nicolas J. Dedy Emil H. Schemitsch Michael D. McKee 《HSS journal》2018,14(1):88-98
Background
Successful treatment of clavicle malunion represents a major challenge for orthopedic surgeons.Questions/Purposes
The aim of this study was to provide an overview of surgical options for the treatment of clavicle malunions regarding their technical details and clinical results.Methods
A comprehensive search of the literature was performed to retrieve articles and conference abstracts regarding the surgical treatment of clavicle malunions. A total of 1873 records were identified and 29 studies were included in the present review, with a total of 103 patients.Results
The majority of the patients (77/103) were treated with an osteotomy and subsequent open reduction internal fixation (ORIF). The next most frequent management choice was debridement, excision, or removal of excess callus or bone (n = 19), but other techniques like resection of the clavicle (n = 5) or nerve exploration and decompression (n = 2) were also reported. The preferred method of fixation was plate fixation (n = 53) followed by pin fixation (n = 6). The complication rate was low, reported in less than 6% of patients.Conclusion
All of the currently reported surgical techniques to manage symptomatic clavicle malunion have resulted in good clinical outcomes with a low complication rate. Considering biomechanical aspects, correction osteotomy followed by plate fixation seems to be the preferred method. Further studies are needed to compare the various surgical techniques and their specific outcomes in a prospective manner. Nevertheless, this review article can be used as an overview to help choose an optimal operative treatment for patients presenting with a clavicle malunion.4.
Clinical and structural results of partial supraspinatus tears treated by subacromial decompression without repair 总被引:1,自引:0,他引:1
Dennis Liem Semra Alci Nicolas Dedy Jörn Steinbeck Björn Marquardt Gunnar Möllenhoff 《Knee surgery, sports traumatology, arthroscopy》2008,16(10):967-972
Patients with primary impingement and articular sided partial tears of the supraspinatus are often treated by subacromial
decompression without repair, if the extent of the tear is estimated to be below 50% of tendon thickness. It has been questioned
whether repair of these cuff lesions is necessary, because these tears could progress to full thickness tears with deteriorating
clinical results. Our hypothesis was that subacromial decompression without repair of the supraspinatus tendon leads to significant
clinical improvement for patients with grade I and II articular sided tears without progression to a full thickness tear on
a regular basis. 46 consecutive patients (av. Age 59.2 years, range 33–76.6 years) were retrospectively reviewed after an
average follow up of 50.3 months (36–86 months). 26 patients (43.5%) had a grade I tear according to Ellman, which was left
alone, 20 patients suffered from a grade II tear, which was debrided. Clinical outcome was assessed with the ASES Score and
ultrasound evaluation was performed on all patients to detect possible progression to a full thickness tear. The average ASES
Score significantly improved from 37.4 to 86.6 points (p < 0.0001). The mean postoperative Constant Score was 87.6 points. Only three patients (6.5%) progressed to a full thickness
tear detectable on ultrasound examination. Only one of these patients had a poor result with an ASES Score of 35 points, the
other two were very satisfied and had an ASES score above 90 points. 8 patients showed no more signs of partial tearing on
ultrasound and these patients had an average ASES Score of 93.1 points. Overall clinical outcome was rated excellent in 35
cases (76.1%), good in 5 (10.9%), average in 2 (4.3%) and poor in 4 (8.7%). Our results indicate that good and excellent results
can be achieved mid- to long term by acromioplasty without repair of the rotator cuff in articular sided partial tears grade
I and II. These results reach almost 95% of the value of a healthy shoulder. A better result on ultrasound examination was
associated with a superior clinical outcome, while progression to a full thickness tear was rare. 相似文献
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Hoell S Butschek S Gosheger G Dedy N Dieckmann R Henrichs M Daniilidis K Hardes J 《The Journal of bone and joint surgery. British volume》2011,93(11):1545-1549
There has been a substantial increase in the number of hip and knee prostheses implanted in recent years, with a consequent increase in the number of revisions required. Total femur replacement (TFR) following destruction of the entire femur, usually after several previous revision operations, is a rare procedure but is the only way of avoiding amputation. Intramedullary femur replacement (IFR) with preservation of the femoral diaphysis is a modification of TFR. Between 1999 and 2010, 27 patients with non-oncological conditions underwent surgery in our department with either IFR (n = 15) or TFR (n = 12) and were included in this study retrospectively. The aim of the study was to assess the indications, complications and outcomes of IFR and TFR in revision cases. The mean follow-up period was 31.3 months (6 to 90). Complications developed in 37% of cases, 33% in the IFR group and 4% in the TFR group. Despite a trend towards a slightly better functional outcome compared with TFR, the indication for intramedullary femur replacement should be established on a very strict basis in view of the procedure's much higher complication rate. 相似文献
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Ming-Jyh Chern Dedy Zulhidayat Noor Ching-Biao Liao & Tzyy-Leng Horng 《Communications In Computational Physics》2015,18(4):1072-1094
A direct-forcing immersed boundary method (DFIB) with both virtual force
and heat source is developed here to solve Navier-Stokes and the associated energy
transport equations to study some thermal flow problems caused by a moving rigid
solid object within. The key point of this novel numerical method is that the solid object,
stationary or moving, is first treated as fluid governed by Navier-Stokes equations
for velocity and pressure, and by energy transport equation for temperature in every
time step. An additional virtual force term is then introduced on the right hand side
of momentum equations in the solid object region to make it act exactly as if it were
a solid rigid body immersed in the fluid. Likewise, an additional virtual heat source
term is applied to the right hand side of energy equation at the solid object region
to maintain the solid object at the prescribed temperature all the time. The current
method was validated by some benchmark forced and natural convection problems
such as a uniform flow past a heated circular cylinder, and a heated circular cylinder
inside a square enclosure. We further demonstrated this method by studying a mixed
convection problem involving a heated circular cylinder moving inside a square enclosure.
Our current method avoids the otherwise requested dynamic grid generation in
traditional method and shows great efficiency in the computation of thermal and flow
fields caused by fluid-structure interaction. 相似文献
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Juniastuti Dedy Wahyuddin Nihayatussa'adah Mochamad Amin Laura Navika Yamani Takako Utsumi Florentina Sustini Maria Inge Lusida 《Journal of medical virology》2019,91(6):1048-1055
Outbreaks of hepatitis A have occurred in some cities in Indonesia. In Surabaya, the capital city of East Java province, Indonesia, hepatitis A outbreaks have been reported since2013, with a marked increase in the number of cases in 2015. The aim of the present study was to analyze the genetic and serology of acute symptomatic cases (early infection) during a hepatitis A outbreak and asymptomatic cases after the outbreak in two junior high schools in Surabaya in 2015 to 2016. Students with acute symptomatic hepatitis A during the outbreak and other students who were asymptomatic 3 to 4 months after the outbreak were enrolled. Asymptomatic students had no symptoms from the outbreak until they were enrolled. Sera were collected to identify anti-hepatitis A virus (HAV) IgM (by enzyme-linked immunosorbent assay) and HAV genetic variations/genotypes (using polymerase chain reaction [PCR]-sequencing and phylogenetic analysis). A total of 33 (97.1%) out of 34 sera of students with acute symptoms were positive for anti-HAV IgM and 18% of them were positive by PCR, identified as HAV subgenotype IA. No prominent amino acid variations were observed from reported HAV sequences from Indonesia. Among 38 sera of asymptomatic students, most (55.3%) were positive for anti-HAV IgM, while none were positive by PCR. In conclusion, HAV-IA was the only subgenotype identified in acute symptomatic cases during the outbreak. The percentage of HAV-specific IgM-positive cases was very high among acute symptomatic students, but that was also high among asymptomatic students, which might contribute as the important source of infection during the outbreak. 相似文献
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Nicolas J. Dedy Martin Stangenberg Dennis Liem Christof Hurschler Beat Simmen Marc Riner Bjoern Marquardt Joern Steinbeck 《International orthopaedics》2011,35(4):549-554
The purpose of this study was to evaluate the effect of eccentric humeral components with different degrees of posterior offset on range of glenohumeral motion in reverse shoulder arthroplasty. Uncemented PROMOS® reverse shoulder prostheses were implanted in eight human cadaveric shoulder specimens. Passive range of motion was evaluated with a robot-assisted shoulder simulator. Three movements were tested: abduction, anterior elevation and external rotation. Each specimen was tested with a customary reverse humeral component and two eccentric components with 3 and 6 mm of posterior offset respectively. Mean abduction was 81° (standard deviation [SD] 12) for the customary reverse components, 81° (SD 13) for the 3 mm eccentric and 82° (SD 15) for 6-mm eccentric implants. Mean anterior elevation was 68° (SD 13) in the regular group and 66° (SD 14) and 63° (SD 14) for 3- and 6-mm eccentric groups. With all configurations, 90° of external rotation were achieved without requiring more than 2 N·m of applied rotational moment. Although there was no statistically significant difference between the conventional and the eccentric implants, anterior elevation was decreased by almost 20° in three of eight shoulders with the posterior offset configurations. This was due to a conflict between the proximal humerus and the anterior aspect of the acromion or the coracoid. Although eccentric humeral components can be useful in reverse shoulder arthroplasty to avoid anterior cortical defects in individuals with pronounced humeral head posterior offset, a potential conflict between proximal humerus and scapula may have an unfavourable effect on range of anterior elevation. However, this observation is only true for the uncemented PROMOS® reverse prosthesis. Other reverse shoulder designs with posterior offset components are yet to be tested. 相似文献