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Frequencies of alpha-1-antitrypsin (Pi) phenotypes were studied in 100 female and 100 male Swedish patients with classical rheumatoid arthritis and compared with the population frequencies. A significant increase of rare Pi types (MS, MZ, MF and SZ) was found among the patients. However, the increase concerned mainly Z heterozygotes and was more strongly pronounced in male patients. The M-subtypes showed no association with rheumatoid arthritis. Previous investigations of Pi types in rheumatoid arthritis have shown somewhat variable results. The results so far indicate, however, that an association between the Z allele and rheumatoid arthritis is likely to exist, while the evidence for a relationship between rheumatoid arthritis and other Pi alleles is considerably weaker. 相似文献
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The original article to which this Erratum refers was published in Pharmacoepidemiology and Drug Safety 11 (8): 647–650. 相似文献
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Å. B. Sævik K. Grønning I. Nermoen S. F. Valland T. E. Finnes M. Isaksson P. Dahlqvist R. Bergthorsdottir O. Ekwall J. Skov B. G. Nedrebø A.‐L. Hulting J. Wahlberg J. Svartberg C. Höybye I. H. Bleskestad A. P. Jørgensen O. Kämpe M. Øksnes E. S. Husebye 《Journal of internal medicine》2018,283(2):190-199
Background
Early detection of autoimmune Addison's disease (AAD ) is important as delay in diagnosis may result in a life‐threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well‐described, but methodical investigations are scarce.Objective
Perform a retrospective audit of patient records with the aim of identifying biochemical markers for early diagnosis of AAD .Material and Methods
A multicentre retrospective study including 272 patients diagnosed with AAD at hospitals in Norway and Sweden during 1978–2016. Scrutiny of medical records provided patient data and laboratory values.Results
Low sodium occurred in 207 of 247 (84%), but only one‐third had elevated potassium. Other common nonendocrine tests were largely normal. TSH was elevated in 79 of 153 patients, and hypoglycaemia was found in 10%. Thirty‐three per cent were diagnosed subsequent to adrenal crisis, in whom electrolyte disturbances were significantly more pronounced (P < 0.001). Serum cortisol was consistently decreased (median 62 nmol L?1 [1–668]) and significantly lower in individuals with adrenal crisis (38 nmol L?1 [2–442]) than in those without (81 nmol L?1 [1–668], P < 0.001).Conclusion
The most consistent biochemical finding of untreated AAD was low sodium independent of the degree of glucocorticoid deficiency. Half of the patients had elevated TSH levels. Only a minority presented with marked hyperkalaemia or other nonhormonal abnormalities. Thus, unexplained low sodium and/or elevated TSH should prompt consideration of an undiagnosed AAD , and on clinical suspicion bring about assay of cortisol and ACTH . Presence of 21‐hydroxylase autoantibodies confirms autoimmune aetiology. Anticipating additional abnormalities in routine blood tests may delay diagnosis.10.
Jenny Alenius Dahlqvist Marcus Karlsson Urban Wiklund Rolf Hörnsten Annika Rydberg 《Journal of electrocardiology》2014