全文获取类型
收费全文 | 1649篇 |
免费 | 74篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 62篇 |
妇产科学 | 121篇 |
基础医学 | 169篇 |
口腔科学 | 6篇 |
临床医学 | 145篇 |
内科学 | 344篇 |
皮肤病学 | 28篇 |
神经病学 | 111篇 |
特种医学 | 56篇 |
外科学 | 227篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 55篇 |
眼科学 | 29篇 |
药学 | 132篇 |
中国医学 | 9篇 |
肿瘤学 | 187篇 |
出版年
2023年 | 10篇 |
2022年 | 10篇 |
2021年 | 33篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 34篇 |
2017年 | 32篇 |
2016年 | 41篇 |
2015年 | 35篇 |
2014年 | 46篇 |
2013年 | 64篇 |
2012年 | 84篇 |
2011年 | 99篇 |
2010年 | 58篇 |
2009年 | 50篇 |
2008年 | 97篇 |
2007年 | 95篇 |
2006年 | 91篇 |
2005年 | 85篇 |
2004年 | 96篇 |
2003年 | 80篇 |
2002年 | 63篇 |
2001年 | 45篇 |
2000年 | 49篇 |
1999年 | 44篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 17篇 |
1995年 | 20篇 |
1994年 | 12篇 |
1993年 | 9篇 |
1992年 | 17篇 |
1991年 | 26篇 |
1990年 | 23篇 |
1989年 | 15篇 |
1988年 | 21篇 |
1987年 | 11篇 |
1986年 | 19篇 |
1985年 | 19篇 |
1984年 | 5篇 |
1983年 | 11篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 8篇 |
1979年 | 10篇 |
1978年 | 6篇 |
1974年 | 4篇 |
1970年 | 3篇 |
1910年 | 4篇 |
1908年 | 8篇 |
排序方式: 共有1728条查询结果,搜索用时 78 毫秒
1.
M Regallo S Scalambrino L Negri F Landoni C Mangioni 《Drugs under experimental and clinical research》1989,15(6-7):315-320
A prospective randomized study was carried out on a total of 686 patients who underwent vaginal or abdominal hysterectomy. Of these, 338 were given prophylactic cefotetan (2 g) and 348 piperacillin (2 g). Both drugs were administered as i.v. bolus 30 min before operation. Findings confirm the higher risk of infection with abdominal hysterectomy and the advantages of the long half-life cephalosporin, cefotetan. 相似文献
2.
E Erba S Pepe P Ubezio A Lorico L Morasca C Mangioni F Landoni M D'Incalci 《British journal of cancer》1986,54(6):925-932
The growth inhibitory effects, the reduction of [3H]-TdR incorporation and the perturbation of the cell cycle induced by the new agent mitozolomide on the M14 human melanoma cell line and on the SW626 human ovarian cancer cell line were compared to those produced by BCNU. Flow cytometry showed an interesting difference: at the high concentration mitozolomide induced an accumulation of cells in S middle and S late-G2-M phase of the cell cycle whereas BCNU caused only a block in S late-G2-M. Further studies were aimed at investigating the susceptibility of freshly isolated human ovarian cancer cells to pharmacologically reasonable mitozolomide concentrations. Only in one out of 16 primary cultures of human ovarian cancers was mitozolomide able to induce cell cycle perturbation, suggesting that ovarian carcinoma cells may not be sensitive to this drug. 相似文献
3.
Cholesterol atheromatous embolism: an increasingly recognized cause of acute renal failure 总被引:3,自引:1,他引:2
Scolari F.; Bracchi M.; Valzorio B.; Movilli E.; Costantino E.; Savoldi S.; Zorat S.; Bonardelli S.; Tardanico R.; Maiorca R. 《Nephrology, dialysis, transplantation》1996,11(8):1607-1612
BACKGROUND.: Cholesterol atheromatous embolism is a systemic disease resultingfrom cholesterol crystal embolization to many organs, includingthe kidney. Vascular surgery, vascular radiology investigationsand anticoagulation have been identified as inciting factors. METHODS.: Fifteen patients with extensive atherosclerosis, presentingwith simultaneous occurrence of acute renal failure and peripheralischaemic changes were diagnosed as having acute renal failuredue to cholesterol atheromatous embolism. RESULTS.: The patients, 12 men and three women, had an average age of65 years. In one patient, spontaneous occurrence of the diseasewas observed. An inciting factor was identified in 14 patients:aortography in 10, aortic surgery in two, and thrombolysis intwo. Clinical course of acute renal failure was quite variable.Four patients required dialysis; 11 were conservatively managed.All patients had concomitant skin lesions, including digitalmottling, cyanosis and gangrene of the toes, and livedo reticularisof the lower limb and abdomen. Eosinophilia was the most commonlaboratory abnormality. The diagnosis of cholesterol atheromatousembolism was confirmed by tissue examination in eight; in threeit was based on the finding of retinal cholesterol emboli; infourpatients it was made on clinical grounds. Seven patientsdied within 36 months. Death was most commonly from cardiaccauses. CONCLUSIONS.: Since the population at risk for cholesterol embolism is growingand the disease is iatrogenic in origin, we should expect todetect cholesterol embolism with greater frequency as causeof acute renal failure in the future. 相似文献
4.
P D Costantino E Russell D Reisch R A Breit C Hart 《The American journal of otology》1991,12(5):378-383
Aneurysm formation and rupture within the petrous internal carotid artery (ICA) is an extremely rare occurrence with approximately 10 such cases in the literature. Etiologies of petrous ICA aneurysms include atherosclerosis, closed head trauma, iatrogenic injury during mastoid surgery, chronic middle ear infections, and congenital causes. Therapeutic options include carotid artery ligation, aneurysm resection with or without reconstruction, and radiographically controlled vessel occlusion. The case of a patient who presented with otorrhagia, epistaxis, and transient focal neurologic signs due to a ruptured petrous ICA aneurysm is presented. The incidence, etiology, and anatomy of these aneurysms is reviewed, and the various tests for determining adequacy of collateral cerebral blood flow are described. Factors that affect the selection of surgical versus radiologic control of these lesions are also discussed. 相似文献
5.
Development and phase 1 clinical testing of a conjugate vaccine against meningococcus A and C. 总被引:12,自引:0,他引:12
A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with a carbohydrate content of 25-30%. The final vaccine that contained 11 micrograms of each oligosaccharide and 88 micrograms of CRM 197 was used to immunize mice and rabbits. After the preclinical studies which showed that the vaccine was safe and immunogenic in animal models, a pilot phase 1 clinical trial, blind versus placebo, was performed on adult volunteers. The difference between the incidence of adverse reactions associated with vaccine and placebo administration was not statistically significant. All the volunteers who received the vaccine had a significant increase in antibodies to group A and C meningococcal capsular polysaccharides after the first dose. 相似文献
6.
G Nawara D Portmann L Costantino J P Bébéar 《Revue de laryngologie - otologie - rhinologie》1992,113(1):21-25
The authors have taken an interest in isolated vertiginous symptoms observed from free diving patients. In order to achieve a current bibliographic synthesis, they resume, on basis of 6 cases, the basic principles of the physics theories and the etiopathogenic mechanisms. They try so to help in the understanding of the vestibular clinical signs observed in this successful sport. 相似文献
7.
di Gioia CR Ciallella C d'Amati G Parroni E Nardone AM Gallo P 《Archives of pathology & laboratory medicine》2003,127(9):e367-e370
An infant with normal facies and none of the extracardiac anomalies usually associated with Williams syndrome presented at birth with an echocardiographic pattern of supravalvular pulmonary stenosis and displastic pulmonary valve. A clinical reappraisal was planned at 3 months of age, but the girl died suddenly at home at 2 months of age. At autopsy, both ventricles were hypertrophic, and the valves showed mild dysplasia. The walls of the great arteries were thick, with a "washed leather" consistency, but there was no gross evidence of discrete stenosis. The histologic mosaic appearance of the media of the great arteries, due to elastosis and extreme disarray of the elastic lamellae, prompted a postmortem diagnosis of supravalvar aortic stenosis and suggested a diagnosis of Williams syndrome, which was subsequently confirmed by fluorescence in situ hybridization. Pediatricians and pathologists should be alerted that Williams syndrome in the newborn may present as an isolated supravalvular pulmonary stenosis, whereas supravalvular aortic stenosis becomes clinically significant only a few months later. 相似文献
8.
Cytotoxicity on tumour cells of human mononuclear phagocytes: defective tumoricidal capacity of alveolar macrophages.
下载免费PDF全文
![点击此处可从《Clinical and experimental immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
C Bordignon R Avallone G Peri N Polentarutti C Mangioni A Mantovani 《Clinical and experimental immunology》1980,41(2):336-342
Human cells of the monocyte-macrophage lineage were isolated by adherence from peripheral blood, peritoneal exudate, non-neoplastic ascites, benign ovarian cystic fluid and bronchoalveolar lavages. Cytolytic activity was measured as 3H-thymidine release from prelabelled mKSA TU5 tumour cells over 48-72 hr and cytostasis was evaluated in a 72-hr spectrophotometric assay. Mononuclear phagocytes from the various anatomical sites examined, except lung alveolar spaces, were significantly cytolytic and cytostatic on target cells. Unlike other cells of the monocyte-macrophage lineage, alveolar macrophages were not cytocidal, but significantly inhibited tumour cell proliferative capacity. Peripheral blood monocytes and peritoneal macrophages showed enhanced cytotoxicity in the presence of partially purified human fibroblast interferon or of lymphokine supernatants from mitogen-stimulated lymphocytes. In contrast, interferon did not affect the cytotoxic potential of alveolar macrophages, whereas lymphokines augmented their cytostatic activity and rendered them weakly cytolytic. 相似文献
9.
A Tarantino A Anelli A Costantino A De Vecchi G Monti L Massaro 《Clinical and experimental immunology》1978,32(1):77-85
In twenty-six patients affected by essential cryoglobulinaemia, 188 determinations of serum complement components (SCC) were made. A peculiar pattern was observed which was characterized by: (a) low levels of early components (Clq, Cls and C4), (b) normal levels of C3 and high concentrations of late components (C5, C9) and (c) CH50 values significantly lower than normal. No relationship could be observed between early SCC and C3 levels. Thirty-three crossed immunoelectrophoreses were performed in thirteen patient's blood samples. The C3c peaks were not different from normal. Follow-up data (156 serum samples from twenty-four patients) during a 6-40 month period showed a non-homogeneous SCC behaviour. However, no relationship was found between the complement concentrations and clinical score. These findings suggest that SCC abnormalities are related to a complement hyposynthesis, which could be caused by a reduced C2 production or by a negative feedback effect of active components or their fragments. 相似文献
10.
Poly(lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering 总被引:2,自引:0,他引:2
This study demonstrates the use of biodegradable poly(lactide-co-glycolide) (PLG) microspheres as a moldable scaffold for cartilage tissue engineering. Chondrocytes were delivered to a cylindrical mold with or without PLG microspheres and cultured in vitro for up to 8 weeks. Cartilagenous tissue formed using chondrocytes and microspheres maintained thickness, shape, and chondrocyte collagen type II phenotype, as indicated by type II collagen staining. The presence of microspheres further enhanced total tissue mass and the amount of glycosaminoglycan that accumulated. Evaluation of microsphere composition demonstrated effects of polymer molecular weight, end group chemistry, and buffer inclusion on tissue-engineered cartilage growth. Higher molecular weight PLG resulted in a larger mass of cartilage-like tissue formed and a higher content of proteoglycans. Cartilage-like tissue formed using microspheres made from low molecular weight and free carboxylic acid end groups did not display increases in tissue mass, yet a modest increased proteoglycan accumulation was detected. Microspheres comprised of PLG with methyl ester end groups yielded a steady increase in tissue mass, with no real increase in matrix accumulation. The microencapsulation of Mg(OH)(2) had negative effects on tissue mass and matrix accumulation. The data herein reflect the potential utility of a moldable PLG-chondrocyte system for tissue-engineering applications. 相似文献