全文获取类型
收费全文 | 1417篇 |
免费 | 102篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 35篇 |
妇产科学 | 15篇 |
基础医学 | 138篇 |
口腔科学 | 45篇 |
临床医学 | 183篇 |
内科学 | 176篇 |
皮肤病学 | 20篇 |
神经病学 | 38篇 |
特种医学 | 184篇 |
外科学 | 126篇 |
综合类 | 40篇 |
一般理论 | 1篇 |
预防医学 | 103篇 |
眼科学 | 17篇 |
药学 | 127篇 |
中国医学 | 5篇 |
肿瘤学 | 276篇 |
出版年
2022年 | 4篇 |
2021年 | 16篇 |
2020年 | 6篇 |
2019年 | 15篇 |
2018年 | 22篇 |
2017年 | 21篇 |
2016年 | 14篇 |
2015年 | 24篇 |
2014年 | 31篇 |
2013年 | 51篇 |
2012年 | 61篇 |
2011年 | 63篇 |
2010年 | 49篇 |
2009年 | 62篇 |
2008年 | 50篇 |
2007年 | 59篇 |
2006年 | 62篇 |
2005年 | 106篇 |
2004年 | 83篇 |
2003年 | 40篇 |
2002年 | 40篇 |
2001年 | 62篇 |
2000年 | 53篇 |
1999年 | 39篇 |
1998年 | 28篇 |
1997年 | 46篇 |
1996年 | 26篇 |
1995年 | 30篇 |
1994年 | 27篇 |
1993年 | 12篇 |
1992年 | 24篇 |
1991年 | 18篇 |
1990年 | 25篇 |
1989年 | 22篇 |
1988年 | 20篇 |
1987年 | 25篇 |
1986年 | 23篇 |
1985年 | 20篇 |
1984年 | 17篇 |
1983年 | 18篇 |
1982年 | 17篇 |
1981年 | 19篇 |
1980年 | 17篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1975年 | 9篇 |
1974年 | 3篇 |
1960年 | 2篇 |
排序方式: 共有1532条查询结果,搜索用时 15 毫秒
1.
Microporous, poly(epsilon-caprolactone) (PCL) matrices were loaded with progesterone by precipitation casting using co-solutions of PCL and progesterone in acetone. Progesterone loadings up to 32% w/w were readily achieved by increasing the drug content of the starting PCL solution. The kinetics of steroid release in PBS at 37 degrees C over 10 days could be described effectively by a diffusional release model although the Korsmeyer-Peppas model indicated the involvement of multiple release phenomena. The diffusion rate constant (D) increased from 8 to 24 microg/mg matrix/day0.5 as the drug loading increased from 3.6 to 12.4% w/w. A total cumulative release of 75%-95% indicates the high efficiency of steroid delivery. Increasing the matrix density from 0.22 to 0.39 g/cm3, by increasing the starting PCL solution concentration, was less effective in changing drug release kinetics. Retention of anti-proliferative activity of released steroid was confirmed using cultures of breast cancer epithelial (MCF-7) cells. Progesterone released from PCL matrices into PBS at 37 degrees C over 14 days retarded the growth of MCF-7 cells by a factor of at least 3.5 compared with progesterone-free controls. These findings recommend further investigation of precipitation-cast PCL matrices for delivery of bioactive molecules such as anti-proliferative agents from implanted, inserted or topical devices. 相似文献
2.
3.
4.
Acute and chronic pharmacokinetics of asymmetrical doses of slow release choline theophyllinate in asthma.
下载免费PDF全文
![点击此处可从《British journal of clinical pharmacology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
S G Hibberd C Alveyn E J Coombes S T Holgate 《British journal of clinical pharmacology》1986,22(3):337-341
The day and night pharmacokinetics of assymetrical doses of slow release choline theophyllinate (Sabidal SR 270) were compared at day 1 and at day 4 of treatment when steady state had been achieved. Ten patients with chronic asthma were given oral choline theophyllinate 424 mg at 09.00 h and 848 mg at 21.00 h for 4 days. At regular intervals during day 1 and day 4 of treatment theophylline concentrations were measured in plasma and dried blood spots by fluorimmunoassay. Theophylline concentrations measured from dried blood spots were slightly lower than those in plasma, the difference remaining constant at all time points during day 1 and day 4 of treatment. On day 1 the mean peak plasma theophylline concentration was 5.4 +/- 1.0 (+/- s.e. mean) micrograms ml-1 4 h after the morning dose and 11.2 +/- 1.6 micrograms ml-1 4 h after the evening dose which were significantly (P less than 0.01) different. Similarly the areas under the plasma theophylline concentration-time curves at night were significantly (P less than 0.001) greater than those observed during the day. During day 4 mean peak plasma concentrations of theophylline after the morning and larger evening dose were 13.2 +/- 1.3 and 12.1 +/- 1.4 micrograms ml-1 respectively, which were not significantly different. No significant difference was observed between the areas under the plasma theophylline concentration-time curves during the day and at night. However the post-dose time to peak was significantly delayed at night (6 h) compared to the morning (2 h, P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
6.
7.
M A al-Jubouri E J Coombes R M Young N P McLaughlin 《Journal of clinical pathology》1994,47(9):850-851
A young woman presented with progressive yellowing of her skin over a period of six months. Liver function tests were requested by her general practitioner and the results prompted the Chemical Pathology Department to instigate further tests to reach the final diagnosis. Hypercarotenaemia had caused her yellow skin, and various other biochemical abnormalities pointed towards primary hypothyroidism as an underlying cause. Thyroxine replacement treatment successfully corrected all the biochemical abnormalities including hypercarotenaemia. As far as is known, yellow skin as a sole presenting feature of hypothyroidism is extremely rare. 相似文献
8.
AG Nettetal 《MedR Medizinrecht》2007,25(11):664-666
Abstrakt 1. Nimmt ein Patient einen ihm von seinem (Zahn-)Arzt einger?umten Exklusiv-Termin nicht wahr, obwohl er auf dessen Eigenschaft
ausdrücklich hingewiesen wurde, so hat er dem (Zahn-)Arzt den Behandlungsausfall abzüglich eines angemessenen Eigenanteils
des (Zahn-)Arztes zu ersetzen.
2. Die Ersatzpflicht tritt auch dann ein, wenn der Patient den Termin nicht in der in dem Behandlungsvertrag vorgesehenen
Frist absagt. Eine hierfür seitens des (Zahn-)Arztes bestimmte Frist von zwei Tagen vor Behandlungsbeginn stellt sich für
den Patienten grunds?tzlich auch nicht als unangemessene Benachteiligung i.S. des § 307 BGB dar.
3. Ein Anspruch des Arztes entf?llt auch bei nur mündlicher Vereinbarung nicht unter dem Gesichtspunkt des § 4 Abs. 5b BMV-Z,
denn diese Vorschrift ist teleologisch dahin zu reduzieren, dass nur zahn?rztliche Honoraransprüche aus erfolgten Behandlungen
schriftlich vereinbart werden müssen. Soweit es jedoch um einen vertraglichen Anspruch wegen einer Leistungsst?rung geht,
vermag das Schriftformerfordernis des § 4 Abs. 5b BMV-Z grunds?tzlich nicht einzugreifen. (Leits?tze des Bearbeiters) 相似文献
9.
10.
Early during rat thymus ontogeny, an important proportion of thymocytes
expresses IL-2R and contains IL-2 mRNA. To investigate the role of the
IL-2-IL-2R complex in rat T cell maturation, we supplied either recombinant
rat IL-2 or blocking anti-CD25 mAb to rat fetal thymus organ cultures
(FTOC) under several experimental conditions. The IL-2 treatment initially
stimulated the growth of thymocytes and, as a result, induced T cell
differentiation, but the continuous addition of IL-2 to rat FTOC, as well
as the anti-CD25 administration, resulted in cell number decrease and
inhibition of thymocyte maturation. These results indicate that immature
rat thymocytes bear functional high- affinity IL-2R and that IL-2 promotes
T cell differentiation as a consequence of its capacity to stimulate cell
proliferation. Modifications in TCR alpha beta repertoire and increased
numbers of NKR- P1+ cells, largely NK cells, were also observed in
IL-2-treated FTOC. Furthermore, IL-2-responsiveness of different thymocyte
subsets changed throughout thymic ontogeny. Immature CD4-CD8-cells
responded to IL-2 in two stages, early in thymus development and around
birth, in correlation with the maturation of two distinct waves of thymic
cell progenitors. Mature CD8+ thymocytes maximally responded to IL-2 around
birth, supporting a role for IL-2 in the increased proliferation of mature
thymocytes observed in vivo in the perinatal period. Taken together, these
findings support a role for IL-2 in rat T cell development.
相似文献