全文获取类型
收费全文 | 2696篇 |
免费 | 155篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 97篇 |
妇产科学 | 61篇 |
基础医学 | 377篇 |
口腔科学 | 94篇 |
临床医学 | 283篇 |
内科学 | 625篇 |
皮肤病学 | 68篇 |
神经病学 | 152篇 |
特种医学 | 313篇 |
外科学 | 309篇 |
综合类 | 31篇 |
预防医学 | 158篇 |
眼科学 | 46篇 |
药学 | 205篇 |
中国医学 | 12篇 |
肿瘤学 | 94篇 |
出版年
2022年 | 17篇 |
2021年 | 44篇 |
2020年 | 25篇 |
2019年 | 38篇 |
2018年 | 59篇 |
2017年 | 29篇 |
2016年 | 34篇 |
2015年 | 53篇 |
2014年 | 54篇 |
2013年 | 77篇 |
2012年 | 100篇 |
2011年 | 89篇 |
2010年 | 78篇 |
2009年 | 86篇 |
2008年 | 94篇 |
2007年 | 160篇 |
2006年 | 91篇 |
2005年 | 90篇 |
2004年 | 74篇 |
2003年 | 81篇 |
2002年 | 77篇 |
2001年 | 70篇 |
2000年 | 96篇 |
1999年 | 89篇 |
1998年 | 99篇 |
1997年 | 96篇 |
1996年 | 63篇 |
1995年 | 76篇 |
1994年 | 53篇 |
1993年 | 45篇 |
1992年 | 43篇 |
1991年 | 58篇 |
1990年 | 45篇 |
1989年 | 64篇 |
1988年 | 70篇 |
1987年 | 55篇 |
1986年 | 58篇 |
1985年 | 66篇 |
1984年 | 33篇 |
1983年 | 24篇 |
1982年 | 36篇 |
1981年 | 22篇 |
1980年 | 31篇 |
1979年 | 19篇 |
1978年 | 17篇 |
1977年 | 19篇 |
1976年 | 19篇 |
1975年 | 14篇 |
1972年 | 12篇 |
1971年 | 12篇 |
排序方式: 共有2936条查询结果,搜索用时 281 毫秒
1.
Transplacental IgG Subclass Concentrations in Pregnancies at Risk of Haemolytic Disease of the Newborn 总被引:5,自引:0,他引:5
A. Lubenko Marcela Contreras C.H. Rodeck U. Nicolini Julia Savage and H. Chana 《Vox sanguinis》1994,67(3):291-298
The relationship of haemolytic disease of the newborn (HDN) to the transplacental passage of the four IgG subclasses was assessed at varous gestational ages by comparing the maternal and fetal IgG subclass concentrations in 34 pregnancies at risk of HDN with those in 30 pregnancies not at risk. Higher maternal and fetal IgG1 levels were attained in pregnancies at risk of HDN than in pregnancies not at risk. In contrast, a slight decrease in maternal IgG2 and IgG4 levels occurred in pregnancies at risk of HDN, as compared with a slight rise in maternal IgG2 and IgG4 levels in pregnancies not at risk of HDN. Changes in fetal IgG2 and 4 concentrations in either type of pregnancy were very similar, showing only slight increases between the 19th and 34th week of gestation. A slight decrease in maternal IgG3 occurred in both types of pregnancy. In contrast, higher and fairly steady levels of fetal IgG3 were observed in fetuses not at risk of HDN throughout gestation, when compared with those in 'at risk' pregnancies. However, the statistical reliability of these results is not clear since only small numbers of samples were tested and because wide variations in IgG concentrations were observed. The IgG subclass concentrations in 50 paired maternal and cord blood samples were also measured and revealed that IgG1 levels were substantially higher in cord rather than maternal blood; cord and maternal IgG2, 3 and 4 levels, on the other hand, were fairly similar. 相似文献
2.
Coronary artery bypass grafts: visualization with MR imaging 总被引:1,自引:0,他引:1
3.
4.
D. Chemla P. Démolis M. Thyrault D. Annane Y. Lecarpentier and JF Giudicelli 《Fundamental & clinical pharmacology》1996,10(4):393-399
Summary— The influence of local resistance and cardiac performance on peripheral blood acceleration was investigated in 14 healthy male volunteers. Steady and pulsatile flow was studied in the brachial and in the common carotid arteries, ie, two territories that exhibit marked differences in resistive characteristics. Instantaneous blood velocity (V), mean blood velocity (Vm ) and artery diameter (D) were evaluated at rest by an ultrasonic range-gated pulsed Doppler flowmeter using a double transducer probe, thus allowing the calculation of mean blood flow (Q). Mean local resistance (R) was obtained by dividing the mean arterial pressure by Q. The peak value of the local acceleration of the blood was obtained by computer-assisted calculation of the first derivative of instantaneous blood velocity (Gmax = +dV/dtmax ). Peak aortic blood acceleration (GAo) was simultaneously measured from the suprasternal notch using a pulsed Doppler velocity meter. In the brachial and the common carotid arteries, Gmax was of a similar magnitude (551 ±30 and 555 ± 44 cm/s2 , respectively) despite major differences in the respective D, Vm , Q and R values. In neither artery was there a relationship between Gmax and either resting Q or R. At the brachial artery level, Gmax was positively related to GAo ( r = 0.79, P = 0.0008). At the common carotid artery level, there was a weak, although non significant relationship between Gmax and GAo ( P = 0.08). Our results indicate that the local acceleration of peripheral blood flow in the brachial artery is related rather to upstream central impulse than to downstream hemodynamics, and suggest some regional differences in the hemodynamic determinants of the local acceleration of peripheral blood flow. 相似文献
5.
In a prospective, randomized, double-blind study, 49 patients underwent lumbar myelography using iotrol (24 patients) or metrizamide (25 patients). The diagnostic imaging adequacy of iotrol was comparable with that of metrizamide. After iotrol myelography, adverse reactions were fewer, less severe, and of shorter duration than were those following metrizamide myelography. Thirteen of 24 patients (54%) receiving iotrol reported some adverse reactions compared with 24 of 25 patients (96%) receiving metrizamide. Five moderate and one severe adverse reaction occurred in the group receiving iotrol. Fourteen moderate and eight severe adverse reactions occurred in the group receiving metrizamide. Thirty-eight patients underwent electroencephalography both before and after myelography (19 iotrol and 19 metrizamide). None of the EEGs obtained after iotrol myelography changed from baseline, while seven of the EEGs obtained after metrizamide myelography showed changes from baseline. Iotrol was judged superior to metrizamide as a contrast medium in this patient population. 相似文献
6.
7.
Chronic exposure of humans to benzene (BZ), a myelotoxin, causes aplastic anemia and acute leukemia. The stromal macrophage that produces interleukin-1 (IL-1), a cytokine essential for hematopoiesis, is a target of BZ's toxicity. Monocyte dysfunction and decreased IL-1 production have been shown to be involved in aplastic anemia in humans. Hydroquinone (HQ), a toxic bone marrow (BM) metabolite of BZ, causes time- and concentration-dependent inhibition of processing of the 34-Kd pre-interleukin-1 alpha (IL-1 alpha) to the 17-Kd mature cytokine in murine P388D1 macrophages and BM stromal macrophages, as measured by Western immunoblots of cell lysate proteins using a polyclonal rabbit antimurine IL-1 alpha antibody. HQ over a 10-fold concentration range had no effect on the lipopolysaccharide (LPS)-induced production of pre- IL-1 alpha precursor or on cell viability or DNA and protein synthesis. Stromal macrophages obtained from the femoral BM of C57Bl/6 mice exposed to BZ (600 or 800 mg/kg body weight) for 2 days were incapable of processing the 34-Kd pre-IL-1 alpha to the mature 17-Kd cytokine when stimulated in culture with LPS. Stromal macrophages from mice coadministered BZ and indomethacin, a prostaglandin H synthase (PHS) inhibitor that has been shown to prevent BZ-induced myelotoxic and genotoxic effects in mice when coadministered with benzene were able to convert the pre-IL-1 alpha to mature cytokine. Administration of recombinant murine IL-1 alpha (rMuIL-1 alpha) to mice before a dose of BZ that causes severe depression of BM cellularity completely prevents BM depression, most probably by bypassing the inability of the stromal macrophage in BZ-treated animals to process pre-IL-1 alpha to the mature cytokine. 相似文献
8.
F Monroy-Guzmán L V Díaz-Archundia A Contreras Ramírez 《Applied radiation and isotopes》2003,59(1):27-34
Zirconium molybdate gels have shown to be viable alternatives for preparation of 99mTc generators using 99Mo produced by neutron activation. The aim of this work was to investigate the effect of the Zr:Mo molar ratio on the gel chemical structure and correlate it with the elution efficiency. A series of gels were prepared at Zr:Mo molar ratios from 0.5:1 to 2.3:1 and characterized by TGA, IR, XRD and UV. It was found that the variation of Zr:Mo ratio produces different polymolybdate arrangements on the octahedral units around to the zirconia which is mainly influenced by the water content. When the matrix molybdenum concentration was increased a lesser amount of water was found and the elution efficiencies were increased. However high elution efficiencies produce higher 99Mo breakthrough values. The gel formulation appears thus to be a compromise between the elution efficiency and the molybdenum breakthrough. The chemical-physical properties of these gels are presented and discussed. 相似文献
9.
F. Contreras J. L. Rodriguez-Peralto J. Palacios M. Patron R. Martin-Molinero 《Journal of cutaneous pathology》1987,14(4):238-241
We report the case of a 67-year-old man with a granular, cauliflower-pink lesion on the skin of the thigh. Histopathological study showed a typical verrucous carcinoma associated with a syringadenoma papilliferum. To our knowledge this association has not been previously reported. 相似文献
10.
Pernes JM; Vitoux JF; Brenoit P; Raynaud A; Parola JL; Roth JP; Angel CY; Fiessinger JN; Roncato M; Gaux JC 《Radiology》1986,158(2):481-485
Thirty-five patients hospitalized for recent angiographically documented arterial occlusion in the legs (27 femoropopliteal arteries and eight grafts) benefited from local fibrinolytic therapy delivered at the site of the occlusion with a 4- or 5-F catheter. This therapy combined a continuous urokinase (UK) infusion of 1,000 U/kg/hour and a lysyl plasminogen (LYS-PLG) infusion of 15 microkatals every 30 minutes. Angiographically confirmed lysis was obtained in 85% of the cases. Only 3% of the patients had major and 6% had minor groin hematomas. Only two patients had concentrations of fibrinogen as low as 100 mg/dl. Intravascular infusion of UK-LYS-PLG is as effective as streptokinase. Its excellent tolerance makes it a good alternative in the treatment of acute ischemia in the lower limbs. 相似文献