全文获取类型
收费全文 | 15821篇 |
免费 | 1185篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 97篇 |
儿科学 | 475篇 |
妇产科学 | 271篇 |
基础医学 | 2776篇 |
口腔科学 | 167篇 |
临床医学 | 1655篇 |
内科学 | 3224篇 |
皮肤病学 | 280篇 |
神经病学 | 1517篇 |
特种医学 | 523篇 |
外国民族医学 | 1篇 |
外科学 | 2207篇 |
综合类 | 189篇 |
一般理论 | 3篇 |
预防医学 | 1347篇 |
眼科学 | 254篇 |
药学 | 957篇 |
中国医学 | 50篇 |
肿瘤学 | 1080篇 |
出版年
2023年 | 55篇 |
2022年 | 126篇 |
2021年 | 228篇 |
2020年 | 184篇 |
2019年 | 287篇 |
2018年 | 302篇 |
2017年 | 243篇 |
2016年 | 270篇 |
2015年 | 344篇 |
2014年 | 415篇 |
2013年 | 618篇 |
2012年 | 925篇 |
2011年 | 991篇 |
2010年 | 593篇 |
2009年 | 570篇 |
2008年 | 955篇 |
2007年 | 971篇 |
2006年 | 1023篇 |
2005年 | 1039篇 |
2004年 | 1020篇 |
2003年 | 1083篇 |
2002年 | 1048篇 |
2001年 | 224篇 |
2000年 | 179篇 |
1999年 | 193篇 |
1998年 | 274篇 |
1997年 | 219篇 |
1996年 | 180篇 |
1995年 | 171篇 |
1994年 | 154篇 |
1993年 | 128篇 |
1992年 | 106篇 |
1991年 | 111篇 |
1990年 | 109篇 |
1989年 | 92篇 |
1988年 | 96篇 |
1987年 | 85篇 |
1986年 | 101篇 |
1985年 | 101篇 |
1984年 | 93篇 |
1983年 | 98篇 |
1982年 | 93篇 |
1981年 | 87篇 |
1980年 | 88篇 |
1979年 | 63篇 |
1978年 | 65篇 |
1977年 | 55篇 |
1976年 | 58篇 |
1975年 | 44篇 |
1974年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Cromb Amandine Le Loarer Franois Sitbon Maxime Italiano Antoine Stoeckle Eberhard Buy Xavier Kind Michle 《European radiology》2020,30(5):2413-2424
European Radiology - The strongest adverse prognostic factor in myxoid/round cell liposarcomas (MRC-LPS) is the presence of a round cell component above 5% within the tumor bulk. Its identification... 相似文献
2.
3.
4.
5.
6.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
7.
8.
9.
Characterization of gp 50, a major glycoprotein present in rat brain synaptic membranes, with a monoclonal antibody 总被引:4,自引:0,他引:4
Philip W. Beesley Toni Paladino Claude Gravel Richard A. Hawkes James W. Gurd 《Brain research》1987,408(1-2):65-78
Several cell lines secreting monoclonal antibodies (Mabs) against a major forebrain synaptic membrane (SM) glycoprotein, gp 50, have been raised. Western blots show that the Mabs react with a polypeptide doublet of Mrs 49 and 45 kDa. These polypeptides exist solely in a concanavalin A (Con A) binding form. Removal of the Con A receptors by digestion with endo-beta-N-acetylglucosaminidase H (endo H) lowers the Mrs of the glycoprotein doublet to 36.5 and 34 kDa. Western blots of 2D polyacrylamide gels indicate that gp 50 exists in several isoforms. Solid phase radioimmunoassay (RIA) and Western blots of brain subcellular fractions show the antigenic material to be concentrated in the SM fraction, but to be present in much lower amounts in synaptic junctions and postsynaptic densities. Gp 50 appears to be brain specific. Regional distribution studies show that it is present in all brain regions but is two-fold concentrated in cerebellum, brainstem and midbrain compared to forebrain. Immunocytochemical studies of several brain regions show that gp 50-like immunoreactivity is neuron specific and is concentrated in selected neuronal species, particularly granule cells. In both cerebellar and hippocampal granule cells gp 50-like immunoreactivity is localized in the perikarya and primary dendrites. Though immunocytochemistry did not show staining of synaptic regions this may be due to masking of the reactive epitope. The results are discussed in terms of the molecular properties of gp 50 and its subcellular localization in brain tissue. 相似文献
10.