全文获取类型
收费全文 | 2807篇 |
免费 | 94篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 56篇 |
妇产科学 | 43篇 |
基础医学 | 373篇 |
口腔科学 | 368篇 |
临床医学 | 282篇 |
内科学 | 437篇 |
皮肤病学 | 66篇 |
神经病学 | 116篇 |
特种医学 | 16篇 |
外科学 | 244篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 543篇 |
眼科学 | 21篇 |
药学 | 172篇 |
中国医学 | 31篇 |
肿瘤学 | 74篇 |
出版年
2024年 | 2篇 |
2023年 | 25篇 |
2022年 | 47篇 |
2021年 | 77篇 |
2020年 | 53篇 |
2019年 | 72篇 |
2018年 | 110篇 |
2017年 | 74篇 |
2016年 | 83篇 |
2015年 | 114篇 |
2014年 | 157篇 |
2013年 | 151篇 |
2012年 | 242篇 |
2011年 | 311篇 |
2010年 | 171篇 |
2009年 | 109篇 |
2008年 | 214篇 |
2007年 | 198篇 |
2006年 | 170篇 |
2005年 | 157篇 |
2004年 | 127篇 |
2003年 | 115篇 |
2002年 | 102篇 |
2001年 | 7篇 |
2000年 | 1篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
排序方式: 共有2913条查询结果,搜索用时 15 毫秒
1.
2.
Ana Cecília Montes Gil Raquel Lorenzetti Gun Bergsten Mendes André Moreno Morcillo Adyléia Aparecida Dalbo Contrera Toro Marcos Tadeu Nolasco da Silva Maria Marluce dos Santos Vilela 《Revista paulista de medicina》2007,125(4):205-209
CONTEXT AND OBJECTIVE: Adverse drug reactions are a significant problem in patients on antiretroviral therapy (ART). We determined liver enzyme elevation frequencies in HIV-infected children and adolescents receiving ART, and their association with risk factors. DESIGN AND SETTING: Cross-sectional study, at the Pediatrics Immunodeficiency Division, University Hospital, Universidade Estadual de Campinas. METHODS: Medical records of 152 children and adolescents (54.6% male; median age 7.48 years) were analyzed, with a mean of 2.6 liver enzyme determinations per patient. Clinically, patients were classified in categories N (6), A (29), B (78) and C (39). Serum levels of aspartate aminotransferase and alanine aminotransferase were evaluated. Hepatotoxicity was scored as grade 1 (1.1-4.9 times upper limit of normality, ULN), grade 2 (5.0-9.9 times ULN), grade 3 (10.0-15.0 times ULN) and grade 4 (> 15.0 times ULN). To assess hepatotoxicity risk factors, odds ratios (OR) and adjusted odds ratios (aOR) for age, gender, TCD4+ cell count, viral load and medication usage were calculated. RESULTS: We observed grade 1 hepatotoxicity in 19.7 % (30/152) patients. No cases of grade 2, 3 or 4 were detected. There was a significant association between hepatotoxicity and use of sulfonamides (OR, 3.61; 95% confidence interval (CI), 1.50-8.70; aOR, 3.58; 95% CI, 1.44-8.85) and antituberculous agents (OR, 9.23; 95% CI, 1.60-53.08; aOR, 9.05; 95% CI, 1.48-55.25). No toxicity was associated with ART. CONCLUSIONS: One fifth of patients experienced mild hepatotoxicity, attributed to antituberculous agents and sulfonamides. Our results suggest that ART was well tolerated. 相似文献
3.
de Andrade AL Pimenta FC Laval CA de Andrade JG Guerra ML Brandileone MC 《Journal of clinical microbiology》2004,42(5):2345-2346
We present a case of invasive pneumococcal infection in a healthy 10-month-old infant from whom Streptococcus pneumoniae serotype 23F was isolated from the blood and serotype 23B was isolated from the cerebrospinal fluid. Both serotypes were penicillin nonsusceptible. Pulsed-field gel electrophoresis analysis demonstrated that the two serotypes had distinct DNA patterns, indicating that infection did not occur as a result of capsular transformation but as a result of a mixed infection with two distinct pneumococcal serotypes. 相似文献
4.
Genetic relationship between Streptococcus pneumoniae isolates from nasopharyngeal and cerebrospinal fluid of two infants with Pneumococcal Meningitis 下载免费PDF全文
de Andrade AL Pimenta FC Brandileone MC Laval CA Guerra ML de Andrade JG Di Fabio JL 《Journal of clinical microbiology》2003,41(8):3970-3972
The molecular epidemiology of Streptococcus pneumoniae isolates from carriage and cerebrospinal fluid (CSF) concurrently recovered from the same individual has not yet been reported. By using pulsed-field gel electrophoresis, we demonstrated the genetic linkage among strains from CSF and nasopharynges of two children with pneumococcal meningitis. 相似文献
5.
Rocha-Rodrigues DB Paschoini G Pereira SA dos Reis MA Teixeira Vde P Rodrigues Júnior V 《Clinical and diagnostic laboratory immunology》2003,10(5):741-743
Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response. 相似文献
6.
Oliveira CJ Carvalho LF Fernandes SA Tavechio AT Menezes CC Domingues FJ 《Microbial drug resistance (Larchmont, N.Y.)》2002,8(4):407-411
The aim of this study was to determine the antimicrobial resistance patterns of Salmonella strains isolated from slaughter-age pigs and environmental samples collected at modern swine raising facilities in Brazil. Seventeen isolates of six serotypes of Salmonella enterica subsp. enterica were isolated out of 1,026 collected samples: Salmonella Typhimurium (1), Salmonella Agona (5), Salmonella Sandiego (5), Salmonella Rissen (1), Salmonella Senftenberg (4), and Salmonella Javiana (1). Resistance patterns were determined to extended-spectrum penicillin (ampicillin), broad-spectrum cephalosporins (cefotaxime and ceftriaxone), aminoglycosides (streptomycin, neomycin, gentamicin, amikacin, and tobramycin), narrow-spectrum quinolone (nalidixic acid), broad-spectrum quinolone (ciprofloxacin and norfloxacin), tetracycline, trimethoprim, and chloramphenicol. Antimicrobial resistance patterns varied among serotypes, but isolates from a single serotype consistently showed the same resistance profile. All isolates were resistant to tetracycline, streptomycin, and nalidixic acid. One isolate, Salmonella Rissen, was also resistant to cefotaxime and tobramycin. All serotypes were susceptible to ceftriaxone, norfloxacin, ciprofloxacin, ampicillin, gentamicin, and chloramphenicol. The high resistance to tetracycline and streptomycin may be linked to their common use as therapeutic drugs on the tested farms. No relation was seen between nalidixic acid and fluoroquinolone resistance. 相似文献
7.
8.
Barroso Rosmeire Aparecida Navarro Ricardo Tim Carla Roberta de Paula Ramos Lucas de Oliveira Luciane Dias Araki Ângela Toshie Fernandes Karina Gonzales Camara Macedo Daniela Assis Lívia 《Lasers in medical science》2021,36(6):1235-1240
Lasers in Medical Science - Acne vulgaris is the most recurring skin condition in the world, causing great harm to the physical and psychological well-being of many patients. Antimicrobial... 相似文献
9.
Stamborowski Sadi Fernando de Oliveira Spinelli Bruna Moreira Lima Fernanda Pupio Silva Costa Davidson Ribeiro de Silveira Souza Gabriela Aparecida Lima Mario Oliveira Lopes Martins Rodrigo Alvaro Brandão 《Lasers in medical science》2021,36(8):1741-1749
Lasers in Medical Science - Physical activity raises body temperature. However, the literature does not contain studies about whether the employment of hotobiomodulation (PMB) could significantly... 相似文献
10.
Reduction of cell proliferative activities of gastric stump adenomatous hyperplasias after bile reflux diversion in rats 总被引:4,自引:1,他引:3
Imai Toshio; Kobayasi Shoiti; Rodrigues Maria Aparecida Marchesan; Camargo Joao Lauro Viana de; Ogawa Kumiko; Iwata Hitoshi; Tatematsu Masae 《Carcinogenesis》1993,14(9):1765-1769
Previously we reported the majority of lesions induced by bilereflux, in the absence of chemical carcinogens, in the rat remnantstomach to consist primarily of gastric type and secondarilyof intestinal type cells, and that they are reversible afterdiversion of bile reflux. The present study was designed toevaluate changes in proliferative activities in cells of eachtype under these conditions. The frequency of adenomatous hyperplasia(AH) induced in the gastric stump mucosa by duodenal contentreflux after Billroth II partial gastrectomy (BII) increaseduntil the 54th week of the experiment. Roux-en-Y (RY) surgicalprocedure which prevents duodenal reflux performed at the 24thor 36th week after BII led to a decrease in AH. Cell contentof the lesions was analyzed using routine H&E staining,immunohistochemical staining for pepsinogen isoenzyme 1 andhistochemical procedures for mucins (paradoxical concanavalinA, galactose oxidase Schiff and sialidase galactose oxidaseSchiff reactions) and proliferation in each compartment evaluatedby an immunohistochemical method using bromodeoxyuridine (BrdU)and a monoclonal antibody against BrdU. At the 54th week thenumber of BrdU-labeled cells per normal pyloric column was significantly(P < 0.05) increased to 10.63/pit after the BII operation,while it diminished to 5.23/pit after RY diversion, this beingthe same level as with the RY procedure alone. AH maintaineda high rate of BrdU incorporation at 12.7% after BII operation,which was also significantly reduced (P < 0.01) to 7.0% bythe RY surgery. The intestinal type cell showed highest (22.2%),the surface mucous type cell showed the next (16.5%) and thepyloric gland type cell showed lowest (5.2%) BrdU labeling indicesafter BII operation. All the cell types in AH showed similarproportional decreases in BrdU incorporation after RY diversion.Thus surgical intervention reverses the cell proliferation causedby bile reflux in the gastric stump. 相似文献