全文获取类型
收费全文 | 2654篇 |
免费 | 211篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 137篇 |
妇产科学 | 52篇 |
基础医学 | 379篇 |
口腔科学 | 116篇 |
临床医学 | 307篇 |
内科学 | 415篇 |
皮肤病学 | 89篇 |
神经病学 | 155篇 |
特种医学 | 256篇 |
外科学 | 228篇 |
综合类 | 39篇 |
一般理论 | 2篇 |
预防医学 | 340篇 |
眼科学 | 25篇 |
药学 | 124篇 |
1篇 | |
中国医学 | 7篇 |
肿瘤学 | 204篇 |
出版年
2023年 | 16篇 |
2022年 | 21篇 |
2021年 | 60篇 |
2020年 | 44篇 |
2019年 | 56篇 |
2018年 | 77篇 |
2017年 | 54篇 |
2016年 | 62篇 |
2015年 | 84篇 |
2014年 | 81篇 |
2013年 | 141篇 |
2012年 | 160篇 |
2011年 | 137篇 |
2010年 | 143篇 |
2009年 | 98篇 |
2008年 | 128篇 |
2007年 | 144篇 |
2006年 | 112篇 |
2005年 | 128篇 |
2004年 | 117篇 |
2003年 | 104篇 |
2002年 | 91篇 |
2001年 | 25篇 |
2000年 | 13篇 |
1999年 | 34篇 |
1998年 | 90篇 |
1997年 | 95篇 |
1996年 | 70篇 |
1995年 | 61篇 |
1994年 | 46篇 |
1993年 | 48篇 |
1992年 | 15篇 |
1991年 | 33篇 |
1990年 | 17篇 |
1989年 | 44篇 |
1988年 | 38篇 |
1987年 | 26篇 |
1986年 | 21篇 |
1985年 | 22篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 15篇 |
1981年 | 19篇 |
1980年 | 16篇 |
1979年 | 4篇 |
1978年 | 13篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1954年 | 1篇 |
排序方式: 共有2888条查询结果,搜索用时 15 毫秒
1.
Barouyr Baroudjian Dimitri Arangalage Stefania Cuzzubbo Baptiste Hervier Celeste Lebbé Gwenael Lorillon 《Expert review of anticancer therapy》2019,19(3):209-222
Introduction: Immune checkpoint inhibitors (ICI) are now a standard of care in the treatment of many cancers leading to durable responses in patients with metastatic disease. These agents are generally well tolerated but may lead to the occurrence of immune-related adverse events (irAEs). As any organ may be affected, clinicians should be aware of the broad range of clinical manifestations and symptoms and keep in mind that toxicities may occur late, at any point along a patient’s treatment course. Although the most common irAEs are rarely severe, some of them may be associated with great morbidity and even become life-threatening. The rate of occurrence, type and severity of irAEs may vary with the type of ICI; thus, grade 3 and 4 irAEs are reported in more than 55% of patients treated with the combination of ipilimumab 3 mg/kg and nivolumab 1 mg/kg.
Area covered: This review presents the management of irAEs resulting from checkpoint blockade, with a focus on rare irAEs.
Expert commentary: With the development of immuno-oncology and the expanding role of ICI, physicians have learnt to diagnose and treat most of the irAEs that can occur. This review provides an overview of current guidelines, previously published studies and our multidisciplinary team based practices. 相似文献
2.
Yannick Marchand Celeste D Lefebvre John F Connolly 《International journal of psychophysiology》2006,62(2):280-289
Event-related brain potentials (ERPs) were recorded during a computerized and modified version of the Digit Span Backwards (DB) task from the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III). The modified DB version (ERP-DB task) was divided into two sections of 2, 4, 6 and 8 digits in length (Group 1) and 3, 5 and 7 digits in length (Group 2). Each trial had a study phase and a test phase. For the study phase, a series of digits was presented sequentially and aurally to 20 participants (10 for each group). For the test phase, a second series of digits was also presented sequentially and aurally that either corresponded to the reverse order of the digits in the study phase (correct condition) or had one digit in the sequence replaced by an incorrect digit (incorrect condition). The traditional DB task of the WAIS-III was also administered for comparison purposes. A prolonged positive slow wave (PSW) peaking between 450 and 750 ms was elicited to incorrect condition trials. For each participant, a derived measure was calculated from the ERP differentiation between correct and incorrect conditions. The derived measure was defined as the mean of the t-values obtained from the correct and incorrect waveform comparison, within the temporal interval that encompassed this component. The strongest statistical correlations between the derived measure and the traditional DB test scores were found at the Pz site (Group 1: r=0.79; Group 2: r=0.59). This statistical approach shows that it is possible to adequately relate an individual's performance on a traditional measure of working memory and ERP patterns. Overall, we believe that this kind of ERP approach holds promise as a technique for assessing quantitatively non-communicative patients. 相似文献
3.
4.
5.
6.
Pyomyositis: characteristics at CT and MR imaging 总被引:9,自引:0,他引:9
7.
AJ Larner MRCP 《International journal of clinical practice》1994,48(5):272-274
SUMMARY A case is reported of pseudohyperphosphataemia in association with a monoclonal gammopathy of undetermined significance. 相似文献
8.
Immunocytochemical and histochemical studies in the tiger salamander and bullfrog demonstrated the presence of luteinizing hormone-releasing hormone-like immunoreactive (LHRH-ir) material and acetylcholinesterase (AChE) in the terminal nerve (TN). Immunoreactive perikarya and processes were found within the olfactory, vomeronasal and trigeminal nerves and in the nasal epithelium. Central TN projections consisted of fibers terminating in the olfactory bulb and bundles that projected to another group of LHRH-ir perikarya in the preoptic region. Up to 4 weeks following hypophysectomy, the labeling intensity and number of TN-immunoreactive neurons were not altered. Acetylcholinesterase histochemistry in the salamander revealed two distinct groups of neurons associated with the TN: a lightly labeled group of fusiform perikarya was located in the olfactory nerve proper and a more heavily labeled group of larger oval perikarya was found within AChE-positive trigeminal fascicles in the ventral mucosa. This study has demonstrated that the amphibian TN follows olfactory, vomeronasal and trigeminal nerves to reach peripheral targets in the nasal mucosa. The projection of TN fibers to discrete olfactory bulb glomeruli, especially evident in the bullfrog, suggests that the TN functions in odor processing. The TN projection to the preoptic region in both of these amphibians implicates the TN in reproductive processes. 相似文献
9.
10.
D De AJ Kanwar S Handa 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):853-859
BACKGROUND: Diagnosis of atopic dermatitis (AD) depends on clinical features because no definitive diagnostic test exists. Criteria proposed by Hanifin and Rajka (Acta Derm Venereol (Stockh) 1980; Suppl 92: 44-47) were acceptable for hospital-based studies but were found not to be suitable for field studies. A UK working party formulated clinical diagnostic criteria that could be used in both hospital and epidemiological settings. Validation studies of the criteria showed widely variable results, probably due to different clinical settings and ethnicity. AIM AND OBJECTIVE: This study was undertaken to validate Hanifin and Rajka's criteria and to assess the comparative efficacy of their criteria and the UK working party's diagnostic criteria in the diagnosis of AD in a hospital setting in North India. SUBJECTS AND METHODS: This study serially included 101 patients with AD and 48 controls of paediatric age group. The study period was from July 2003 to December 2004. RESULTS: Hanifin and Rajka's criteria (sensitivity 96%, specificity 93.75%, positive predictive value 97% (PPV) and negative predictive value (NPV) 91.84%) had a statistical advantage over the UK working party's diagnostic criteria (sensitivity 86%, specificity 95.83%, PPV 97.75% and NPV 76.67%), with a P-value < 0.005. 相似文献