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排序方式: 共有251条查询结果,搜索用时 25 毫秒
1.
New evidence from magnetic resonance imaging of brain changes after climbs at extreme altitude 总被引:1,自引:0,他引:1
Eduardo Garrido Ramón Segura Antoni Capdevila Jordi Aldomá Ferrán A. Rodríguez Casimiro Javierre Josep Ll. Ventura 《European journal of applied physiology》1995,70(6):477-481
The aim of the present study was to look for anatomical changes in climbers' brains, using magnetic resonance imaging (MRI), after extremely high-altitude climbs and to relate them to possible associated risk factors. Clinical history, neurological examinations and MRI were carried out on a group of nine climbers before and after climbing to over 7500 m without the use of supplementary oxygen. None of the subjects showed any neurological dysfunctions. In five climbers MRI abnormalities (high signal areas, cortical atrophy) were observed before the expedition. After the descent, two of them showed new high intensity signal areas recorded by MRI. Both subjects suffered severe neurological symptoms during the climb. The present study suggested that the brain changes observed by MRI could be related to the severity of clinical events at high altitude. However, we do not know the exact meaning of such MRI findings or the reason for their location, predominantly in posterior regions of the brain. The new evidence that a high percentage of climbers show MRI brain abnormalities, and especially the appearance of changes after the ascent, reinforces the possibility of a potential neurological risk in high-altitude climbing. 相似文献
2.
This paper analyzes the high relevance of material selection for the sustainable development of an LED weatherproof light fitting. The research reveals how this choice modifies current and future end of life scenarios and can reduce the overall environmental impact. This life cycle assessment has been carried out with Ecotool, a software program especially developed for designers to assess the environmental performance of their designs at the same time that they are working on them. Results show that special attention can be put on the recycling and reusing of the product from the initial stages of development. 相似文献
3.
Paulo Sérgio da Silva Márcio Portugal Trindade Cartacho Casimiro Cardoso de Castro Marcello Fonseca Salgado Filho Ant?nio Carlos Aguiar Brand?o 《Brazilian Journal Of Cardiovascular Surgery》2015,30(4):449-458
Objective
To evaluate the influence of pulmonary hypertension in the ultra-fast-track anesthesia technique in adult cardiac surgery.Methods
A retrospective study. They were included 40 patients divided into two groups: GI (without pulmonary hypertension) and GII (with pulmonary hypertension). Based on data obtained by transthoracic echocardiography. We considered as the absence of pulmonary hypertension: a pulmonary artery systolic pressure (sPAP) <36 mmHg, with tricuspid regurgitation velocity <2.8 m/s and no additional echocardiographic signs of PH, and PH as presence: a sPAP >40 mmHg associated with additional echocardiographic signs of PH. It was established as influence of pulmonary hypertension: the impossibility of extubation in the operating room, the increase in the time interval for extubation and reintubation the first 24 hours postoperatively. Univariate and multivariate analyzes were performed when necessary. Considered significant a P value <0.05.Results
The GI was composed of 21 patients and GII for 19. All patients (100%) were extubated in the operating room in a medium time interval of 17.58±8.06 min with a median of 18 min in GII and 17 min in GI. PH did not increase the time interval for extubation (P=0.397). It required reintubation of 2 patients in GII (5% of the total), without statistically significant as compared to GI (P=0.488).Conclusion
In this study, pulmonary hypertension did not influence on ultra-fast-track anesthesia in adult cardiac surgery. 相似文献4.
Micaela Piccoli Ferdinando Agresta Vincenzo Trapani Casimiro Nigro Vito Pende Fabio Cesare Campanile Nereo Vettoretto Enrico Belluco Paolo Pietro Bianchi Davide Cavaliere Giuseppe Ferulano Filippo La Torre Marco Maria Lirici Roberto Rea Gianni Ricco Elena Orsenigo Simona Barlera Emanuele Lettieri Giovanni Maria Romano 《International journal of colorectal disease》2014,29(8):1029-1029
5.
6.
Gabriele Di Sante Timothy G. Pestell Mathew C. Casimiro Sara Bisetto Michael J. Powell Michael P. Lisanti Carlos Cordon-Cardo Mireia Castillo-Martin Dennis M. Bonal Valentina Debattisti Ke Chen Liping Wang Xiaohong He Michael W. McBurney Richard G. Pestell 《The American journal of pathology》2015,185(1):266-279
7.
8.
Knollmann BC Casimiro MC Katchman AN Sirenko SG Schober T Rong Q Pfeifer K Ebert SN 《The Journal of pharmacology and experimental therapeutics》2004,310(1):311-318
To determine whether the neonatal mouse can serve as a useful model for studying the molecular pharmacological basis of Long QT Syndrome Type 1 (LQT1), which has been linked to mutations in the human KCNQ1 gene, we measured QT intervals from electrocardiogram (ECG) recordings of wild-type (WT) and Kcnq1 knockout (KO) neonates before and after injection with the beta-adrenergic receptor agonist, isoproterenol (0.17 mg/kg, i.p.). Modest but significant increases in JT, QT, and rate-corrected QT (QTc) intervals were found in KO neonates relative to WT siblings during baseline ECG assessments (QTc = 57 +/- 3 ms, n = 22 versus 49 +/- 2 ms, n = 28, respectively, p < 0.05). Moreover, JT, QT, and QTc intervals significantly increased following isoproterenol challenge in the KO (p < 0.01) but not the WT group (p = 0.57). Furthermore, whole-cell patch-clamp recordings show that the slow delayed rectifier K+ current (IKs) was absent in KO but present in WT myocytes, where it was strongly enhanced by isoproterenol. This finding was confirmed by showing that the selective IKs inhibitor, L-735,821, blocked IKs and prolonged action potential duration in WT but not KO hearts. These data demonstrate that disruption of the Kcnq1 gene leads to loss of IKs, resulting in a long QT phenotype that is exacerbated by beta-adrenergic stimulation. This phenotype closely reflects that observed in human LQT1 patients, suggesting that the neonatal mouse serves as a valid model for this condition. This idea is further supported by new RNA data showing that there is a high degree of homology (>88% amino acid identity) between the predominant human and mouse cardiac Kcnq1 isoforms. 相似文献
9.
Evans RK Zhu DM Casimiro DR Nawrocki DK Mach H Troutman RD Tang A Wu S Chin S Ahn C Isopi LA Williams DM Xu Z Shiver JW Volkin DB 《Journal of pharmaceutical sciences》2004,93(7):1924-1939
We describe the physiochemical characterization and immunological evaluation of plasmid DNA vaccine formulations containing a nonionic triblock copolymer adjuvant (CRL1005) in the presence and absence of a cationic surfactant, benzalkonium chloride (BAK). CRL1005 forms particles of 1-10 microns upon warming above its phase-transition temperature (approximately 6-8 degrees C) and the physical properties of the particles are altered by BAK. DNA/CRL1005 vaccines formulated with and without BAK were evaluated in rhesus macaques to determine the effect of CRL1005 and BAK on the ability of plasmid DNA to induce a cellular immune response. Immunogenicity results indicate that the addition of CRL1005 to human immunodeficiency virus-1 gag plasmid DNA formulated in phosphate-buffered saline leads to an enhancement in the gag-specific cellular immune response. Moreover, the addition of BAK to human immunodeficiency virus-1 gag plasmid DNA/CRL1005 formulations produces an additional enhancement in gag-specific cellular immunity. In vitro characterization studies of DNA/CRL1005 formulations indicate no detectable binding of DNA to CRL1005 particles in the absence of BAK, suggesting that the enhancement of cellular immunity induced by DNA/CRL1005 formulations is not due to enhanced DNA delivery. In the presence of BAK, however, results indicate that BAK binds to CRL1005 particles, producing cationic microparticles that bind DNA through electrostatic interactions. If BAK is present at the phase-transition temperature, it reduces the particle size from approximately 2 microns to approximately 300 nm, presumably by binding to hydrophobic surfaces during particle formation. Zeta potential measurements indicate that the surface charge of CRL1005-BAK particles changes from positive to negative upon DNA binding, and DNA bound to the surface of CRL1005-BAK particles was visualized by fluorescence microscopy. These results indicate that the addition of BAK to DNA/CRL1005 formulations leads to the formation of approximately 300 nm CRL1005-BAK-DNA particles that enhance the cellular immune response in rhesus monkeys. 相似文献
10.
Heritability of explosive power and anaerobic capacity in humans 总被引:2,自引:0,他引:2
Calvo M Rodas G Vallejo M Estruch A Arcas A Javierre C Viscor G Ventura JL 《European journal of applied physiology》2002,86(3):218-225
There is a disparity in the information about the heritability of the response of muscle anaerobic metabolism to exercise
and the use of explosive power, as well as a lack of information concerning the genetic determinants of this form of work,
as measured using different specific physical tests. We applied a battery of some of the commonly employed procedures (Ergojump,
Wingate, maximal accumulated oxygen deficit, excess post-exercise oxygen consumption, and Δ lactate concentration) to a group
of 32 Caucasian male twins, 8 monozygotic and 8 dizygotic pairs, who had similar environmental backgrounds. Results were studied
using a heritability index (HI). Zygosity was determined using the identity of erythrocyte antigens, protein and enzyme polymorphism
and human leucocyte antigen serologic types between co-twins. Significant HI values (P<0.05) were found in the following tests: maximal 5 s power (HI=0.74) and total power in a 30 s interval (HI=0.84) in the
Wingate test, maximal lactate concentration (HI=0.82) and Δ lactate concentration (HI=0.84) in the maximal progressive test,
as well as in the 2nd (HI=0.93) and in the 3rd min (HI=0.92) of recovery after the deficit test. In this study, the most relevant
findings were: firstly, significant HI values for many of the variables studied; secondly, the HI values of the parameters
used to evaluate explosive power were higher than those of lactic acid capacity and thirdly, the HI of certain variables from
different tests measuring, in theory, similar qualities, were different.
Electronic Publication 相似文献