全文获取类型
收费全文 | 1716771篇 |
免费 | 129021篇 |
国内免费 | 5957篇 |
专业分类
耳鼻咽喉 | 21923篇 |
儿科学 | 55868篇 |
妇产科学 | 46440篇 |
基础医学 | 244539篇 |
口腔科学 | 49180篇 |
临床医学 | 154668篇 |
内科学 | 336899篇 |
皮肤病学 | 38873篇 |
神经病学 | 132401篇 |
特种医学 | 64806篇 |
外国民族医学 | 263篇 |
外科学 | 259790篇 |
综合类 | 43200篇 |
现状与发展 | 13篇 |
一般理论 | 535篇 |
预防医学 | 125550篇 |
眼科学 | 40800篇 |
药学 | 126252篇 |
37篇 | |
中国医学 | 5920篇 |
肿瘤学 | 103792篇 |
出版年
2021年 | 14355篇 |
2019年 | 14451篇 |
2018年 | 20966篇 |
2017年 | 16085篇 |
2016年 | 17441篇 |
2015年 | 20275篇 |
2014年 | 27844篇 |
2013年 | 39221篇 |
2012年 | 54648篇 |
2011年 | 57583篇 |
2010年 | 34084篇 |
2009年 | 31720篇 |
2008年 | 52845篇 |
2007年 | 56206篇 |
2006年 | 56585篇 |
2005年 | 53998篇 |
2004年 | 51589篇 |
2003年 | 48908篇 |
2002年 | 47066篇 |
2001年 | 92306篇 |
2000年 | 94136篇 |
1999年 | 77564篇 |
1998年 | 20188篇 |
1997年 | 17720篇 |
1996年 | 17777篇 |
1995年 | 17087篇 |
1994年 | 15563篇 |
1993年 | 14230篇 |
1992年 | 57568篇 |
1991年 | 55406篇 |
1990年 | 53088篇 |
1989年 | 50858篇 |
1988年 | 46265篇 |
1987年 | 45020篇 |
1986年 | 42302篇 |
1985年 | 40042篇 |
1984年 | 29381篇 |
1983年 | 24933篇 |
1982年 | 13913篇 |
1979年 | 25544篇 |
1978年 | 17578篇 |
1977年 | 14907篇 |
1976年 | 13875篇 |
1975年 | 14565篇 |
1974年 | 17631篇 |
1973年 | 16933篇 |
1972年 | 15664篇 |
1971年 | 14435篇 |
1970年 | 13415篇 |
1969年 | 12504篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
1.
Ecotoxicology - Soil heavy metal pollution evaluations are a necessary measure for mine ecological control projects. In this study, the heavy metals Pb, Zn and Cd were studied in mining areas,... 相似文献
2.
Molnár B. Aroca S. Dobos A. Orbán K. Szabó J. Windisch P. Stähli A. Sculean A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with... 相似文献
3.
目的收集特重度烧伤(总TBSA50%以上或三度TBSA20%以上或伴有严重并发症者)患者围术期凝血指标(APTT、PT、FIB、DD和PLT),分析静吸复合麻醉对患者凝血功能的影响及其临床意义。
方法选取近3年内蒙古医科大学第三附属医院烧伤外科收治的特重度烧伤患者148例,根据入院14 d内的预后分为死亡组和生存组,生存组男性129例,女性9例;年龄24~59岁,平均(43.30±12.90)岁。死亡组男性8例,女性2例;年龄26~63岁,平均(46.19±15.41)岁。收集入院时(T0),术前(早晨入手术室前,T1),术毕(送至PACU未拔除气管导管前,T2)及术后2 d(T3)4个时间点的凝血指标,比较两组凝血指标动态差异。
结果死亡组休克期输液量、累计血浆、红细胞输入量显著高于生存组(P<0.01)。T0时,生存组的FIB(1.78±0.32)显著高于死亡组(1.26±0.07)(P<0.05);T2时,两组APTT、PT均显著缩短(P<0.05),生存组的FIB(3.86±0.40)显著高于死亡组(2.45±1.02)(P<0.05);T3时,死亡组PLT显著低于生存组(P<0.01)。
结论特重度烧伤患者在围手术期易出现高凝状态,并且这可能导致患者死亡。静吸复合麻醉和围术期大量液体复苏会促进患者的高凝状态。 相似文献
4.
Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are
increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic
methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent.
Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography
(UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure
the expression levels of miR-144-5p and miR-26b-5p in the plasma of patients with BC. The receiver operating characteristics (ROC) curve and area under the curve (AUC) were used to investigate the potential diagnostic value of miR-
144-5p, miR-26b-5p and the elastographic score in BC. Results: The ultrasonic elastography score(UES) was found to
be significantly upregulated in BC compared with that in benign breast lesions, and the AUC, sensitivity and specificity
were 0.809, 0.717 and 0.806 for distinguishing BC from benign breast lesions, respectively. miR-144-5p and miR-26b-
5p were found to be upregulated in the plasma of BC patients, and miR-144-5p+miR-26b-5p had 0.781 sensitivity and
0.780 specificity for the diagnosis of BC. Furthermore, we found that the diagnostic performance of miR-144-5p and
miR-26b-5p combined with UES for BC had 0.913 sensitivity and 0.890 specificity. Conclusions: The combination of
plasma miR-144-5p, miR-26b-5p and UES has a very high clinical application value for the early detection of BC. 相似文献
5.
Kienbaum Peter Schaefer Maximilian S. Weibel Stephanie Schlesinger Tobias Meybohm Patrick Eberhart Leopold H. Kranke Peter 《Der Anaesthesist》2022,71(2):123-128
Die Anaesthesiologie - Auch wenn für Anästhesiologen über Jahrzehnte die Prophylaxe und Therapie postoperativer Schmerzen im Rahmen des postoperativen Patientenkomforts an vorderster... 相似文献
6.
7.
痛情绪是指因疼痛引发的情绪和情感体验,是疾病过程中最常见的一种情绪。痛情绪相关神经机制非常复杂,但主要与单胺类神经递质、神经肽和某些神经环路有关,笔者将结合目前研究现状分别从以上两方面展开,就痛情绪相关单胺类神经递质和神经肽在受体分类、脑区通路、共疾病以及各神经递质之间的联系和痛情绪相关神经环路中各个蛋白的作用机制等方面进行探讨。 相似文献
8.
9.
Wuteng Cao Huabin Hu Jiao Li Qianyu Wu Lishuo Shi Biao Li Jie Zhou Xinhua Wang Junhong Chen Chao Wang Huaiming Wang Weihao Deng Yan Huang Yanhong Deng 《International journal of cancer. Journal international du cancer》2023,153(11):1894-1903
Neoadjuvant programmed cell death protein 1 (PD-1) blockade exhibits promising efficacy in patients with mismatch repair deficient (dMMR) colorectal cancer (CRC). However, discrepancies between radiological and histological findings have been reported in the PICC phase II trial (NCT 03926338). Therefore, we strived to discern radiological features associated with pathological complete response (pCR) based on computed tomography (CT) images. Data were obtained from the PICC trial that included 36 tumors from 34 locally advanced dMMR CRC patients, who received neoadjuvant PD-1 blockade for 3 months. Among the 36 tumors, 28 (77.8%) tumors achieved pCR. There were no statistically significant differences in tumor longitudinal diameter, the percentage change in tumor longitudinal diameter from baseline, primary tumor sidedness, clinical stage, extramural venous invasion status, intratumoral calcification, peritumoral fat infiltration, intestinal fistula and tumor necrosis between the pCR and non-pCR tumors. Otherwise, tumors with pCR had smaller posttreatment tumor maximum thickness (median: 10 mm vs 13 mm, P = .004) and higher percentage decrease in tumor maximum thickness from baseline (52.9% vs 21.6%, P = .005) compared to non-pCR tumors. Additionally, a higher proportion of the absence of vascular sign (P = .003, odds ratio [OR] = 25.870 [95% CI, 1.357-493.110]), nodular sign (P < .001, OR = 189.000 [95% CI, 10.464-3413.803]) and extramural enhancement sign (P = .003, OR = 21.667 [2.848-164.830]) was observed in tumors with pCR. In conclusion, these CT-defined radiological features may have the potential to serve as valuable tools for clinicians in identifying patients who have achieved pCR after neoadjuvant PD-1 blockade, particularly in individuals who are willing to adopt a watch-and-wait strategy. 相似文献