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1.
Pyoderma gangrenosum and related disorders 总被引:2,自引:0,他引:2
J P Callen 《The Medical clinics of North America》1989,73(5):1247-1261
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition with distinctive clinical characteristics and a frequent association with systemic diseases. Most frequently among the associated disease list are: inflammatory bowel disease, arthritis, and a variety of hematologic disorders. There is no specific treatment of PG; however, the effective treatment of an accompanying systemic disease, local therapy, and/or the use of topical or systemic agents known to be useful in neutrophil disorders, have been beneficial in most patients. 相似文献
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Bone marrow and peripheral blood cultures of chronic lymphocytic leukemia patients were mitogenically stimulated with TPA (12-0-tetradecanylphorbol-13-acetate). Clonal cytogenetic abnormalities were detected in frequencies varying from 15% to 100%, in five of the six patients studied. Parallel studies with pokeweek mitogen showed a much lower level of stimulation and only two abnormal clones were detected. The chromosome abnormalities described in this study are similar to those reported in CLL by other authors, particularly with respect to trisomy 12 and deletion 11q. A significant frequency of hypodiploidy and chromosome deletion was also detected in this study, and further studies are underway to determine the significance of these findings. 相似文献
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Small marker chromosomes in man: origin from pericentric heterochromatin of chromosomes 1, 9, and 16. 总被引:10,自引:4,他引:10 下载免费PDF全文
D F Callen M L Ringenbergs J C Fowler C J Freemantle E A Haan 《Journal of medical genetics》1990,27(3):155-159
Three patients with different marker chromosomes were screened by in situ hybridisation using biotinylated probes to chromosome specific pericentric repeats to determine the chromosomal origin of the marker. Each marker had a different origin, with one from each of chromosomes 1, 9, and 16. This is the first time that autosomal marker chromosomes consisting of a small ring have been shown to be derived from the pericentric heterochromatin of metacentric and submetacentric chromosomes. Evidence suggests that such markers are not associated with any significant risk of phenotypic abnormalities, but additional cases need to be studied. 相似文献
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K Callen 《Public health reports (Washington, D.C. : 1974)》1983,98(4):336-343
Part of a Department of Health and Human Services initiative against teenage alcohol abuse, a national Conference for Youth on Drinking and Driving--held March 26-28, 1983 in Chevy Chase, Md. --brought together more than 300 high school student delegates and school superintendents from every State and Territory. The conference spotlighted successful programs that students around the country have undertaken to promote sober driving--programs that incorporate these key principles: (a) they rely almost solely on peer leadership "by students for students"; (b) they employ a "holistic" approach to health promotion, emphasizing self-esteem and alternatives to alcohol and drug abuse; and (c) they use the resources of the whole community. Working with student leaders of these model programs, conference delegates devised ways to launch similar programs in their own schools and communities and to enlist help from parents, teachers, lawmakers, the media, and business and civic groups. The Department of Health and Human Services plans to hold similar conferences annually, to mobilize future generations of students against drunk driving. 相似文献
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回春液补肾助阳药效学的实验研究 总被引:2,自引:0,他引:2
回春液由人参、鹿茸、貂鞭等名贵中药组成。有补肾助阳,填精益气等功效。药效学研究证实,该药有促进幼鼠发育及增加去势大鼠前列腺——精液囊的重量,亦显著增加小鼠血红蛋白的含量,表明回春液有雄性激素样作用。 相似文献
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Kassab A El-Bialy G Hashesh H Callen P 《The journal of obstetrics and gynaecology research》2008,34(1):117-120
Colo-uterine fistula of diverticular origin is an extremely rare disease due to the resistance of uterine tissue. Methods for diagnosis remain to be established. Non-invasive imaging like magnetic resonance imaging (MRI) may help to establish a proper diagnosis, but confirmation may be reached by diagnostic hysteroscopy or even surgical exploration. We report a 78-year-old female who presented with continuous dull aching pain associated with increasing constipation. MRI suspected a fistula between the posterior aspect of the uterine body and the sigmoid colon which contained extensive diverticulosis. Hysteroscopy confirmed the fistulous opening, but colonoscopy confirmed diverticular disease with no evidence of malignancy. The patient had en block surgical treatment of the uterus and the adjacent colon, followed by an uneventful recovery. The sensitivity and specificity of non-invasive imaging procedures to diagnose such cases remain to be established. As imaging procedures cannot rule out neoplasia, endoscopic procedures need to be added. 相似文献