全文获取类型
收费全文 | 144篇 |
免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 3篇 |
基础医学 | 16篇 |
临床医学 | 34篇 |
内科学 | 45篇 |
皮肤病学 | 5篇 |
神经病学 | 1篇 |
外科学 | 11篇 |
预防医学 | 4篇 |
药学 | 31篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2015年 | 4篇 |
2014年 | 10篇 |
2013年 | 8篇 |
2012年 | 3篇 |
2011年 | 1篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2007年 | 2篇 |
2006年 | 1篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2002年 | 2篇 |
2001年 | 3篇 |
1999年 | 2篇 |
1998年 | 7篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1958年 | 1篇 |
1956年 | 2篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有151条查询结果,搜索用时 0 毫秒
1.
PIERLUIGI TABACCHI MARIELLA CHIRICOLO MARINELLA CENCI FRANCESCO BARBONI MARCO MANFRINI GAETANO BACCI PIERO PICCI MARIO CAMPANACCI FEDERICO LICASTRO CLAUDIO FRANCECHI 《Tissue antigens》1982,20(4):251-253
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population. 相似文献
2.
DONATELLA SANTINI CLAUDIO CECCARELLI MARIO TAFFURELLI STEFANO PILERI DOMENICO MARRANO 《The Journal of pathology》1996,179(4):386-391
The expression of intermediate filament proteins (IFPs) in 65 primary breast carcinomas was analysed by a panel of specific antibodies. Results were integrated with the oestrogen and progesterone receptor (ER and PGR) status, Ki-67 marking, and epidermal growth factor receptor (EGFr) expression. Invasive breast carcinomas could be divided into three main groups: group 1 revealed positivity only for ‘simple epithelial’ cytokeratins (CKs 7, 8, 18, and 19); group 2 also stained with the antibodies K8.12 and 34βE12; while group 3 showed co-expression of CKs 14 and 17, vimentin, and α-smooth muscle actin. Group 3 consistently comprised tumours with the highest Ki-67 levels, EGFr positivity, and ER-PGR negative status. On the other hand, groups 1 and 2 usually exhibited a positive hormonal status, lower proliferative activity, and EGFr negativity. The results of this study indicate that the determination of IFPs can significantly contribute to the identification of groups of patients with different biopathological settings and possibly different clinical behaviour. 相似文献
3.
GIUSEPPE MAGLIULO CLAUDIO UNGARI CARLO DELLA ROCCA MASSIMO MUSCATELLO GIANLUCA MARIA VINGOLO 《Clinical otolaryngology》1991,16(5):483-487
The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response. 相似文献
4.
CLAUDIO DE FELICE TOSHIAKI TANAKA K. HAYAKAWA KATZUMI ITOH TAKAYUKI WATANABE NORIYUKI KATSUMATA ITSURO HIBI 《Pediatrics international》1994,36(6):623-626
The contribution of the kidney to the metabolism of prolactin has not yet been established. In the present study, urinary prolactin concentrations in 30 children with renal disease were measured by a newly devised, highly sensitive, time-resolved immunofluorometric assay. Median prolactin concentrations in the urine of children with renal disease, were 1.86 pmol/L−1 of urine (range: 0.17–546.31 pmol/L−1. By stepwise regression analysis, change in urinary prolactin levels as a function of the urinary β 2-microglobulin concentrations was detected. These results indicate that prolactin urinary excretion in children with renal disease is dependent on the renal proximal tubular function. 相似文献
5.
CLAUDIO TONIOLO GIOVANNI VALLE GIAN MARIA BONORA FRANCESCO LELJ VINCENZO BARONE FRANCA FRATERNALI GEORGES CALLET JEAN WAGNON DINO NISATO 《Chemical biology & drug design》1987,30(5):583-595
The conformational preferences and self-association modes of the two diastereomeric N-acetyl, methylamides of 3-hydroxy, 4-amino, 6-methylheptanoic acid (statine) with (R, S) and (S, S) configurations at the 3-hydroxy and 4-amino carbons, respectively, have been determined in solution as well as in the solid state by infrared absorption, 1H nuclear magnetic resonance, and X-ray diffraction. Conformational energy computations have also been performed in parallel. In the crystal state, the change in chirality of the hydroxyl group induces different intermolecular H-bonding schemes in the (R, S) isomer compared to the two structurally distinct molecules in the asymmetric unit of the (S, S) isomer. Different propensities to self-aggregate are seen in solvents of low polarity. In solvents of high polarity, however, the molecules of both isomers are largely solvated, while still keeping some local conformational restriction. Conformational energy computations indicate that in vacuo the two diastereomers exhibit different flexibility, and a preferred conformation with a different type of intramolecular H-bond. 相似文献
6.
ESRS Task Force: DIRK PEVERNAGIE NEIL STANLEY SÖREN BERG JEAN KRIEGER ROBERTO AMICI CLAUDIO BASSETTI MICHEL BILLIARD FABIO CIRIGNOTTA DIEGO GARCIA-BORREGUERO IRENE TOBLER JÜRGEN FISCHER 《Journal of sleep research》2009,18(1):136-141
In recent years, sleep medicine has evolved into a full-grown discipline, featuring a multidisciplinary approach to diagnosis and treatment of patients with sleep disorders. Sleep medicine cuts across the boundaries of different conventional disciplines and is therefore open to medical and non-medical professionals with different specialty backgrounds. The aim of the current paper is to introduce a qualification for those professionals whose main occupation is to practice sleep medicine in the setting of a sleep medicine centre. The drafting of guidelines dealing with requirements for such qualification was entrusted to a task force by the European Sleep Research Society. The guidelines are the result of a progressive consensus procedure in which standards were defined for education, training, and evaluation. The final step along this pathway is a theoretical and practical examination, providing proof of proficiency in the field of sleep medicine. This paper describes the object of specific competences, the scope of sleep medicine, and the qualification procedures that pertain to three professional categories: medical specialists, non-medical professionals with a university master degree (such as psychologists and biologists), and nurses and technologists. Indices of preceding practical experience and theoretical knowledge are presented in Appendices 1 and 2 . These guidelines are a European standard. They may be adapted in the future according to new scientific insights. National certification programs that comply with these guidelines may be subject to homologation by the ESRS. 相似文献
7.
8.
RICHARD M. LUCERI SALEM M. HABAL IRVING B. DAVID RICHARD L. PUCHFERRAN CLAUDIO MURATORE RAFAEL RABINOVICH 《Pacing and clinical electrophysiology : PACE》1993,16(1):159-164
Thirty-four patients underwent implantation of a third generation ICD, the 4210 ATP, for sudden cardiac death or ventricular tachycardia. This device incorporates significant telemetry logs as well as a detailed analysis of each arrhythmia episode detected. During the period of clinical follow-up, a mean of 12.2 months, a total of 26,569 VT or VF detections were made. The vast majority of these were either due to atrial fibrillation, nonsustained VT, or "noise" detection, and only 6% led to device therapy. ATP was successful in 86.3% of episodes, with 3.5% accelerations and 2.4% failure of ATP trains. The majority of inappropriate therapy episodes were clustered in seven patients, and all were easily diagnosed with the aid of the extensive telemetry Jogs and sense histories. Of five late deaths, three were from congestive heart failure, one from cerebrovascular accident, and one unknown. These data reveal that this "tiered" therapy noncommitted ICD performs to expectations; the stored data is of significant value in diagnosing the cause of ICD therapy. In addition, ATP is an effective modality for termination of VT. 相似文献
9.
Impact on Prognosis of Periprocedural Myocardial Infarction after Percutaneous Coronary Intervention
10.
RAFAEL RABINOVICH CLAUDIO MURATORE RICARDO IGLESIAS MIGUEL GONZALEZ VÍCTOR DARÚ MARIANA VALENTINO ALVARO SOSA LIPRANDI RICHARD LUCERI 《Pacing and clinical electrophysiology : PACE》1999,22(1):202-205
The time to first ICD shock has been extensively studied in patients with coronary artery disease (CAD). However, there are no published data on ICD shocks in patients with Chagas cardiomyopathy (ChC). The occurrence of the first appropriate ICD shock during the first 6 months of follow-up in 20 patients with ChC (group 1) and 35 CAD patients (group 2) was analyzed retrospectively. All patients had received a third-generation pectoral ICD for ventricular tachycardia or fibrillation (VT/VF). Indications for ICD implantation were refractoriness to drug therapy or noninducibility of VT/VF at EPS in cardiac arrest survivors. Results: The mean age, left ventricular ejection fraction (LVEF), and sex in groups I and II were 57.4 ± 7 years versus 64 ± 9 (P < 0.01), 30.9%± 10% versus 32.9%± 10% (P = NS), and 10 men versus 31 women (P < 0.005), respectively. Six months after ICD implantation, 85% (17/20) group I patients received appropriate ICD shocks versus 51 % (18/35) in group 2, a statistically significant difference (P < 0.02, RR: 1.65, OR: 5.35). Conclusions: The incidence of appropriate ICD shocks within the first 6 months postimplantation was significantly higher in ChC patients than in CAD patients. ChC patients were younger and more often women than CAD patients. 相似文献