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1.
Epidemic diarrheal disease of suckling mice; the effect of strain,litter, and season upon the incidence of the disease 总被引:2,自引:1,他引:1
Four strains of mice-Harvard, Schwentker, CFW (Carworth Farms), and C (National Cancer Institute)-have been kept and bred underidentical conditions over the course of a year in order to determine the effect of strain, of litter, and of season upon the incidence of diarrheal disease among the suckling mice. 1. Significant strain differences were limited to CFW mice. A consistently lower percentage of these mice were weaned in comparison to the others. 2. The effect of litter was definite and consistent: In all four strains first litters fared worse than second and third ones, while fourth and fifth litters showed the highest percentage of mice weaned. 3. The effect of season seemed clear cut only in the case of one strain CFW; the highest percentage of mice weaned were observed during the summer months and the lowest during the autumn and early winter. 相似文献
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MARION FRANKENBERGER BARBARA HOFMANN BERTOLD EMMERICH CHRISTOPH NERL RETO A. SCHWENDENER & H.W. LÖMS ZIEGLER -HEITBROCK 《British journal of haematology》1997,98(1):186-194
The vitamin D3 derived hormone 1,25 (OH)2 vitamin D3 (1,25 D3 ) is able to induce growth arrest and differentiation in myelomonocytic leukaemia cells. In order to allow for specific delivery to leukaemic cells the lipophilic compound was incorporated into the lipid membranes of liposomes. Liposomal 1,25 D3 reduced proliferation as measured by 3 H-thymidine incorporation in HL60 leukaemia cells by up to 60%. When liposomes were prepared at different concentrations of 1,25 D3 65% inhibition was achieved at 48 n M . The MC 1288 stereoisomer of 1,25 D3 was more potent and had the same activity at 48 n M .
The effect of the liposomal compounds was specific to myeloid cells as they reduced proliferation in myelomonocytic HL60, monoblastic U937 and monocytic Mono Mac 6 cells but not in the T-cell lines Jurkat and Molt 4.
The antiproliferative effect of liposomal 1,25 D3 was associated with an induction of differentiation since treated HL60 cells showed a monocytic morphology, increased expression of CD14 and decreased expression of CD33.
When peripheral blood leukaemic cells from M4 and M5 acute myeloid leukaemia (AML) patients were admixed with liposomal compounds an antiproliferative effect was seen in all five cases, including the two cases where free compounds led to enhanced growth. Liposomal delivery of 1,25 (OH)2 vitamin D3 may offer a novel approach to treatment of myelomonocytic leukaemia. 相似文献
The effect of the liposomal compounds was specific to myeloid cells as they reduced proliferation in myelomonocytic HL60, monoblastic U937 and monocytic Mono Mac 6 cells but not in the T-cell lines Jurkat and Molt 4.
The antiproliferative effect of liposomal 1,25 D
When peripheral blood leukaemic cells from M4 and M5 acute myeloid leukaemia (AML) patients were admixed with liposomal compounds an antiproliferative effect was seen in all five cases, including the two cases where free compounds led to enhanced growth. Liposomal delivery of 1,25 (OH)
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CHRISTOPH STELLBRINK M.D. BJÖRN DIEM M.D. PATRICK SCHAUERTE M.D. KATHRIN ZIEGERT M.D. PETER HANRATH M.D. 《Journal of cardiovascular electrophysiology》1997,8(8):916-921
Coronary Venous Ablation of VT. Ventricular tachycardias in coronary artery disease arise mostly from endocardial sites. However, little is known about the site of origin in other diseases. We present the case of an incessant, adenosine-sensitive ventricular tachycardia arising from the lateral wall of the left ventricle in a patient with mildly reduced left ventricular function. Intracardiac mapping suggested an epicardial origin, and the tachycardia was successfully ablated from a coronary sinus branch. After ablation, left ventricular function returned to normal. Transcoronary venous radiofrequency catheter ablation is a new approach for the treatment of ventricular tachycardia. Its value in the management of other types of ventricular tachycardia has yet to he determined. 相似文献
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A 14-year-old boy with pronounced myotonic dystrophy and cardiac malformation had a normal ED95 (53 μg·kg?1) of vecuronium, whereas the recovery index (25-75% twitch recovery) was three times as long as in the absence of neuromuscular disease. We conclude that in young patients with dystrophic muscle disease individual titration of the muscle relaxant with the aid of a nerve stimulator does not preclude a considerable delay in the recovery of neuromuscular transmission. 相似文献
8.
CHRISTOPH KLEIN BRIGITTE ROCKSTROH RUDOLF COHEN PATRICK BERG MARC DRESSEL 《Psychophysiology》1996,33(4):426-433
In a delayed matching-to-sample task, the impact of clear or ambiguous go versus clear no-go signals on the post-imperative negative variation (PINV) was examined in 11 patients with a chronic schizophrenic disorder (DSM-III-R) and in a control group of 13 healthy subjects matched to the patient sample by age, sex, and education. Size and spatial position of a visual S2 had to be matched to one of two visual patterns in the S1 presented 4 s earlier. In 96 trials, the S2 was identical in size with one of the two patterns of S1 (clear matching). These trials varied pseudorandomly, with 60 trials in which the S2 was of intermediate size. On a randomly interspersed additional 48 trials, an S2 differing in color and shape signaled no-go. The electroencephalogram was recorded from Fz, Cz, Pz, F3, F4, C3, C4, P3, and P4. Although groups did not differ in contingent negative variation amplitude the PINV was generally more pronounced in patients than in controls. In both groups, ambiguity of the to-be-matched S2 produced larger PINV amplitudes; the no-go signal elicited only a small PINV. Differential effects of ambiguity and no-go on PINV amplitude and its scalp distribution suggest that “performance” and “action” uncertainty contribute to PINV generation and that thresholds for both effects are reduced in schizophrenics. 相似文献
9.
VorarlbergAustria'S most western province with a populationof about 325 000has always implemented forms of socialpolicy in which the principles of subsidiarity and solidarityplay an important role. This is reflected in the structure ofthe organizations traditionally providing social services aswell as in the more recent programme.s the government has developedfor social policy. This paper discusses two cases in point: the private associationsfor home care (Krankenpflegerverbände)which nowexist in 65 Vorarlberg communities and cover 85% of the populationin the provinceoffering nursing services at home to membersor to persons who are willing to join the organization whenthey need care, and the new organizational model, called GesunderLebensraum Vorarlberg (GLV), which is successfully operatingin a few pilot communities. GLV has spawned umbrella organizations,run by volunteers, and offering a variety of social servicesrelevant to the elderly, for example visiting services or neighbourhoodhelp in case of emergencies. The volunteers get organizationalhelp from a profit-making firm financed by the government. The Vorarlberg models can be interpreted as a step towards demedicalizationand dein.stitutionalization of health care for the elderly.Nevertheless, they also show the problems that arise when professionalsand volunteers must cooperate. The models may lead to savingsfor the governments involved, although details are still subjectto future empirical investigations. 相似文献
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