全文获取类型
收费全文 | 2556篇 |
免费 | 151篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 162篇 |
妇产科学 | 56篇 |
基础医学 | 373篇 |
口腔科学 | 48篇 |
临床医学 | 209篇 |
内科学 | 469篇 |
皮肤病学 | 39篇 |
神经病学 | 109篇 |
特种医学 | 481篇 |
外科学 | 278篇 |
综合类 | 32篇 |
预防医学 | 124篇 |
眼科学 | 21篇 |
药学 | 120篇 |
中国医学 | 3篇 |
肿瘤学 | 200篇 |
出版年
2023年 | 3篇 |
2022年 | 9篇 |
2021年 | 16篇 |
2020年 | 11篇 |
2019年 | 17篇 |
2018年 | 29篇 |
2017年 | 19篇 |
2016年 | 36篇 |
2015年 | 46篇 |
2014年 | 51篇 |
2013年 | 95篇 |
2012年 | 57篇 |
2011年 | 67篇 |
2010年 | 104篇 |
2009年 | 78篇 |
2008年 | 72篇 |
2007年 | 66篇 |
2006年 | 94篇 |
2005年 | 57篇 |
2004年 | 68篇 |
2003年 | 58篇 |
2002年 | 57篇 |
2001年 | 47篇 |
2000年 | 56篇 |
1999年 | 60篇 |
1998年 | 149篇 |
1997年 | 129篇 |
1996年 | 142篇 |
1995年 | 105篇 |
1994年 | 89篇 |
1993年 | 93篇 |
1992年 | 48篇 |
1991年 | 41篇 |
1990年 | 43篇 |
1989年 | 78篇 |
1988年 | 66篇 |
1987年 | 68篇 |
1986年 | 66篇 |
1985年 | 54篇 |
1984年 | 27篇 |
1983年 | 37篇 |
1982年 | 35篇 |
1981年 | 23篇 |
1980年 | 41篇 |
1979年 | 15篇 |
1978年 | 18篇 |
1977年 | 18篇 |
1976年 | 24篇 |
1975年 | 28篇 |
1966年 | 8篇 |
排序方式: 共有2729条查询结果,搜索用时 0 毫秒
1.
Herlinde Dumez Gunther Guetens Gert De Boeck Martin S Highley Robert A A Maes Allan T van Oosterom Ernst A de Bruijn 《Clinical chemistry and laboratory medicine》2004,42(11):1219-1227
Therapeutic drug monitoring generally focuses on the plasma compartment only. Differentiation between the total plasma concentration and the free fraction (plasma water) has been described for a number of limited drugs. Besides the plasma compartment, blood has also a cellular fraction which has by far the largest theoretical surface and volume for drug transport. It is with anti-cancer drugs that major progress has been made in the study of partition between the largest cellular blood compartment, i.e., erythrocytes, and the plasma compartment. The aim of the present review is to detail the progress made in predicting what a drug does in the body, i.e., pharmacodynamics including toxicity and plasma and/or red blood cell concentration monitoring. Furthermore, techniques generally used in anti-cancer drug monitoring are highlighted. Data for complex Bayesian statistical approaches and population kinetics studies are beyond the scope of this review, since this is generally limited to the plasma compartment only. 相似文献
2.
J. G. Boonstra Johan W. van der Pijl Yves F. C. Smets Herman H. P. J. Lemkes Jan Ringers Leendert A. van Es F. J. van der Woude Jan A. Bruijn 《Transplant international》1997,10(6):451-456
To examine the incidence of interstitial and vascular
rejection in pancreas allografts and its impact on graft survival, we studied 36 percutaneous pancreas biopsies and 10 pancreas
transplantectomy specimens from 32 patients who had undergone simultaneous pancreas-kidney transplantation. Interstitial rejection
(IR) was predominantly found in the biopsies, while vascular rejection (VR) was most prominent in the transplantectomies.
Pancreas graft survival was significantly decreased for pancreas grafts that had suffered from vascular rejection when compared
to those with only interstitial rejection. Potential rejection markers, i. e., serum amylase, glucose, creatinine, and urinary
amylase, did not correlate with histological signs of rejection, although increased levels of serum amylase were, in all but
one case, associated with rejection.We conclude that a percutaneous pancreas biopsy remains the most reliable method to determine
pancreas rejection, and that by distinguishing between IR andVR, a pancreas biopsy may provide important diagnostic as well
as prognostic information.
Received: 6 March 1997 Received after revision: 5 June 1997 Accepted: 30 June 1997 相似文献
3.
P C Hogendoorn J A Bruijn E W Gelok L J Van den Broek G J Fleuren 《Nephrology, dialysis, transplantation》1990,5(2):100-109
A rat model of chronic serum sickness was used to study the pathogenesis of progressive glomerulosclerosis complicating experimental immune-complex glomerulonephritis. Chronic serum sickness was induced by immunising rats with bovine serum albumin followed by intraperitoneal administration of the antigen. Early lesions consisted of mesangial deposits of rat immunoglobulins, followed later by transient subendothelial and persistent subepithelial immune aggregates. On the basis of the peak level of proteinuria around day 80, three groups of rats were distinguished: I physiological proteinuria; II 50-500 mg/24 h; and III greater than 500 mg/24 h. The animals were killed at day 220 and the presence of mesangial proliferation, epithelial proliferation, and synechiae, as well as focal glomerulosclerosis was scored. It appeared that all and only proteinuric animals developed progressive glomerulosclerosis, although all three groups of animals passed through a phase with mesangial and subendothelial immune deposits. A strong correlation was found between the degree of proteinuria and the proportion of glomeruli affected. We conclude that the combination of mesangial and subendothelial deposits on the one hand and subepithelial deposits associated with increased protein loss on the other constitute a conditio sine qua non for the development of progressive glomerulosclerosis in this model. The use of specific antibodies to investigate the composition of the sclerotic lesions showed the presence of laminin and type IV collagen, but not of types I and III collagen in sclerotic areas of glomeruli. This indicates that the development of progressive glomerulosclerosis in this model is due to an increased production of glomerular basement membrane components by presumably solely glomerular cells after the occurrence of immunological glomerular injury. 相似文献
4.
5.
6.
E A De Bruijn H P Sleeboom P J van Helsdingen A T van Oosterom U R Tjaden R A Maes 《International journal of cancer. Journal international du cancer》1992,51(3):359-364
The schedule in dosing of intravesical chemotherapy has thus far received little attention. Correlation of optimal contact time with bladder toxicity, as well as maximal chemotherapeutic effect for one of the drugs of first choice for intravesical instillation, i.e. mitomycin C (MMC), is a particularly important question. In a randomized study, we treated bladder cancer patients with intravesical MMC using 30-min and 60-min dwelling times. There were 28 evaluable patients in each of the 2 groups. The groups were comparable with respect to mean age, sex ratio and distribution of primary or recurrent and single or multiple tumors. Stages and grades of tumors were also comparable over both treatment groups. Pharmacokinetics of MMC and degradation/metabolism were monitored during the first 4 cycles and the last (8th) cycle using HPLC and mass spectrometry. Recurrence was significantly lower in the 60-min treatment group (35.7% vs. 14.3%, chi 2 test; 0.01 less than p less than 0.05). No recurrences were found in patients with Ta and T1 tumors when the 60-min dwelling time was used. Toxicity was mild and transient; the incidence was, surprisingly, lower in the 60-min group but the difference failed to reach the level of significance. Pharmacokinetics of systemic MMC and recovery in the urine was comparable over both groups and systemic absorption was calculated to be in the range of 1-5%. 相似文献
7.
During the past few years a number of technological developments have made new methods of noninvasive cardiac monitoring available for use in the intensive care unit. Some of these can be used almost continuously some repeatedly, but intermittently, to manage critically ill patients. In addition to avoiding the risks of pain, bleeding, and infection associated more with invasive studies, a major advantage of many noninvasive studies is that one is able to conduct them at the bedside. Echocardiography has been most useful in this regard, but now even nuclear imaging can be carried out with commercially available portable scanners. Doppler techniques, formerly understood only by those with considerable background in cardiology have now evolved to provide the clinician with a simple method of measuring cardiac output. ECG monitoring too has undergone recent refinements to automate the detection of ST segment changes that escape routine observation of the bedside monitor. 相似文献
8.
We report an adult female with a rare giant choledochal cyst. The patient presented following a normal pregnancy with the classical triad of an abdominal mass associated with jaundice and right upper quadrant abdominal pain. The cyst was excised using an intramural technique and biliary reconstruction achieved with a Roux-en-Y hepaticojejunostomy. Our patient has remained well with no evidence of malignancy over a 12 year review period. The aetiology and current management of this condition are discussed. 相似文献
9.
10.
Na+ dependence of in vitro pancreatic amylase release 总被引:1,自引:0,他引:1